Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Imma Moreno"'
Autor:
Richard S. Roberts, Maria Antonia Buil, Peter Eichhorn, Paul R. Eastwood, Imma Moreno, Silvia Petit, Pilar Forns, Jordi Castro, Oscar Casado, Manel Ferrer, Miriam Andrés, Marta Calbet
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 24:5111-5117
Pyrrolopiperidinone acetic acids (PPAs) were identified as highly potent CRTh2 receptor antagonists. In addition, many of these compounds displayed slow-dissociation kinetics from the receptor. Structure–kinetic relationship (SKR) studies allowed o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::43cdea5257f6e6d7e0e15c8e6c4dd8b5
https://doi.org/10.1016/j.bmcl.2014.08.026
https://doi.org/10.1016/j.bmcl.2014.08.026
Autor:
Laura Vidal, Miriam Andrés, Marta Mir, Pilar Forns, Sara Sevilla, Bernat Vidal, Estrella Lozoya, Cristina Esteve, Mónica Bravo, Manel Ferrer, Paul R. Eastwood, Richard S. Roberts, Jordi Castro, Elena Gómez, Marta Calbet, Pere Vilaseca, Jacob González, Imma Moreno, Silvia Petit, J. A. Alonso, Maria Antonia Buil
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 24:5127-5133
The correct positioning and orientation of an hydrogen bond acceptor (HBA) in the tail portion of the biaryl series of CRTh2 antagonists is a requirement for long receptor residence time. The HBA in combination with a small steric substituent in the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b468e1247865bc00ad5b1e097179b4b4
https://doi.org/10.1016/j.bmcl.2014.08.028
https://doi.org/10.1016/j.bmcl.2014.08.028
Autor:
Cristina Esteve, Jacob González, Pere Vilaseca, Marta Calbet, Imma Moreno, Marta Mir, Richard S. Roberts, Silvia Petit, Elena Gómez, Mónica Bravo, Miriam Zanuy, J. A. Alonso, Manel Ferrer, Sara Sevilla, Laura Vidal, Peter Eichhorn, Miriam Andrés, Paul R. Eastwood, Bernat Vidal
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 24:5123-5126
Extensive structure–activity relationship (SAR) and structure–kinetic relationship (SKR) studies in the bicyclic heteroaromatic series of CRTh2 antagonists led to the identification of several molecules that possessed both excellent binding and c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::25504733d7dc10ba602aaeb837967766
https://doi.org/10.1016/j.bmcl.2014.08.029
https://doi.org/10.1016/j.bmcl.2014.08.029
Autor:
Richard S. Roberts, Maria Antonia Buil, Manel Ferrer, Marcos Castillo, Miriam Andrés, Mónica Bravo, Martin D. Lehner, Jordi Castro, Sara Sevilla, Peter Eichhorn, Marta Calbet, Imma Moreno
Publikováno v:
European Journal of Medicinal Chemistry. 71:168-184
In this manuscript, the synthesis and biological activity of a series of pyrazole acetic acid derivatives as CRTh2 antagonists is presented. Biological evaluation in vitro revealed that the pyrazole core showed in several cases a different structure-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f943a5d1ab18fbe77a579ca4d9ae5f52
https://doi.org/10.1016/j.ejmech.2013.10.072
https://doi.org/10.1016/j.ejmech.2013.10.072
Autor:
Jordi Serrat, Jordi Gràcia, Judit Cabedo, Lluís Pagès, Dolors Vilella, Martin D. Lehner, Manel Ferrer, Montserrat Miralpeix, Peter Eichhorn, Jordi Castro, Begoña Hernández, Maria Antonia Buil, Victor Segarra, Elena Calama, Sara Sevilla, Carla Carcasona, Miriam Andrés, Joan Taltavull, Imma Moreno, Richard S. Roberts, Amadeu Gavaldà
Publikováno v:
Journal of medicinal chemistry. 59(23)
Cyclic nucleotide cAMP is a ubiquitous secondary messenger involved in a plethora of cellular responses to biological agents involving activation of adenylyl cyclase. Its intracellular levels are tightly controlled by a family of cyclic nucleotide de
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6e14339ed067c1e19efdcae82d84b277
https://pubmed.ncbi.nlm.nih.gov/27933955
https://pubmed.ncbi.nlm.nih.gov/27933955
Discovery of a novel class of zwitterionic, potent, selective and orally active S1P1 direct agonists
Autor:
Gema Tarrasón, Nuria Godessart, Marta Mir, Clara Armengol, Mònica Córdoba, Dolors Vilella, Daniel Casals, Manel López, Victor Segarra, Teresa Doménech, Imma Moreno, M Sabate, Nuria Aguilar, Pedro M. Grima, María Domínguez, Laia Esteban
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 22:7672-7676
Amido-1,3,4-thiadiazoles have been identified as a novel structural class of potent and selective sphingosine-1-phosphate receptor subtype 1 agonists. Starting from a micromolar HTS hit with the help of an in-house homology model, robust structural
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::267ca19860dca563219d7e83fee9d6af
https://doi.org/10.1016/j.bmcl.2012.09.110
https://doi.org/10.1016/j.bmcl.2012.09.110
Autor:
Jordi Sanahuja, Montse Erra, Nuria Godessart, Raquel F. Reinoso, Estrella Lozoya, Imma Moreno, Pilar Pizcueta, Julio C. Castro-Palomino, Miriam Andrés
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 21:7268-7272
The structure–activity relationships of a novel series of biaryl dihydroorotate dehydrogenase (DHODH) inhibitors related to teriflunomide are disclosed. These biaryl derivatives were the result of structure-based design and proved to be potent DHOD
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::490de3d4ae27fb547cdd503041c2caad
https://doi.org/10.1016/j.bmcl.2011.10.052
https://doi.org/10.1016/j.bmcl.2011.10.052
Autor:
Angel F. Remacha, M. Arilla, Imma Moreno, Neus Boto, Adelaida Ramos, Jorge Sierra, Rodrigo Martino, Concepción Pastoret, P Madoz, Clara Martínez, E Muniz-Diaz, C. Canals
Publikováno v:
Transfusion. 44:1603-1611
BACKGROUND: Most studies indicate that ABO incompatibility has no effect on the clinical outcome after allogeneic peripheral blood progenitor cell (PBPC) transplantation (allo-PBPCT). However, it carries additional risks of hemolytic reactions, delay
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1d764ecf4ddebd8c5e574b139aff2c60
https://doi.org/10.1111/j.1537-2995.2004.04106.x
https://doi.org/10.1111/j.1537-2995.2004.04106.x
Autor:
Martin D. Lehner, Teresa Doménech, Imma Moreno, Elena Gómez, Jordi Castro, Maria Antonia Buil, Manel Ferrer, Miriam Andrés, Sara Sevilla, Marta Calbet, Mónica Bravo, Peter Eichhorn, Richard S. Roberts
Publikováno v:
Bioorganicmedicinal chemistry letters. 23(11)
High throughput screening identified the pyrazole-4-acetic acid substructure as CRTh2 receptor antagonists. Optimisation of the compounds uncovered a tight SAR but also identified some low nanomolar inhibitors.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::75b2483b6090420b5414b2ac084f37fb
https://pubmed.ncbi.nlm.nih.gov/23601708
https://pubmed.ncbi.nlm.nih.gov/23601708
Discovery of a novel class of zwitterionic, potent, selective and orally active S1P₁ direct agonists
Autor:
Nuria, Aguilar, Marta, Mir, Pedro M, Grima, Manel, López, Victor, Segarra, Laia, Esteban, Imma, Moreno, Nuria, Godessart, Gema, Tarrasón, Teresa, Domenech, Dolors, Vilella, Clara, Armengol, Mònica, Córdoba, Mar, Sabaté, Daniel, Casals, Maria, Domínguez
Publikováno v:
Bioorganicmedicinal chemistry letters. 22(24)
Amido-1,3,4-thiadiazoles have been identified as a novel structural class of potent and selective sphingosine-1-phosphate receptor subtype 1 agonists. Starting from a micromolar HTS hit with the help of an in-house homology model, robust structural-a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::4b6d390fb1e124b77845c2f17ba30813
https://pubmed.ncbi.nlm.nih.gov/23141913
https://pubmed.ncbi.nlm.nih.gov/23141913