Search for α-glucosidase inhibitors: New N-substituted valienamine and conduramine F-1 derivatives

Autor: Sylvain Favre, Robert Łysek, Pierre Joseph Marcel Jung, Anthony Cornelius O'sullivan, Catherine Schütz, Christian Pillonel, Imma Clotet-Codina, Thomas Krülle, José A. Esté, Pierre Vogel

Publikováno v: Bioorganic & Medicinal Chemistry. 14:6255-6282

A solid-phase synthesis of new N-substituted valienamines has been developed and new synthesis of (±)-conduramine F-1, (−)-conduramine F-1, and (+)- ent -conduramine F-1 is presented, together with the preparation of N-benzylated conduramines F-1.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aad00ded2a9afb57ee9e735532b31827
https://doi.org/10.1016/j.bmc.2006.05.080

A Combination of Molecular Dynamics and Docking Calculations to Explore the Binding Mode of ADS-J1, a Polyanionic Compound Endowed with Anti-HIV-1 Activity

Autor: Imma Clotet-Codina, Maurizio Botta, Mercedes Armand-Ugón, Rino Ragno, Fabrizio Manetti, Cristina Tintori, José A. Esté, Silvio Massa

Publikováno v: Journal of Chemical Information and Modeling. 46:1344-1351

The HIV-1 entry process is an important target for the design of new pharmaceuticals for the multidrug therapy of AIDS. A lot of polyanionic compounds, such as polysulfonated and polysulfated, are reported in the literature for their ability to block

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b46ad9973571bf134ff4b6b2c9b559f7
https://doi.org/10.1021/ci050414h

Acetylcholinesterase-inhibiting alkaloids from Zephyranthes concolor

Autor: Christopher K. Jankowski, Imma Clotet-Codina, Jaume Bastida, Carles Codina, Francesc Viladomat, Sebastien Arseneau, Strahil Berkov, José A. Esté, Simón Hernández-Ortega, Ricardo Reyes-Chilpa

Publikováno v: Molecules
Dipòsit Digital de la UB
Universidad de Barcelona
Molecules; Volume 16; Issue 11; Pages: 9520-9533
Molecules, Vol 16, Iss 11, Pp 9520-9533 (2011)

The bulbs and aerial parts of Zephyranthes concolor (Lindl.) Benth.Hook. f. (Amaryllidaceae), an endemic species to Mexico, were found to contain the alkaloids chlidanthine, galanthamine, galanthamine N-oxide, lycorine, galwesine, and epinorgalantham

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b03db8733fe695e654823d5106afaf4f
https://pubmed.ncbi.nlm.nih.gov/22086403

HIV endocytosis after dendritic cell to T cell viral transfer leads to productive virus infection

Autor: Jordi Senserrich, Ester Ballana, Ruth Peña, Margarita Bofill, Bonaventura Clotet, María Teresa Fernández-Figueras, Berta Bosch, Imma Clotet-Codina, José A. Esté

Publikováno v: Antiviral research. 83(1)

Contacts between HIV-producing T cells and primary CD4+ T cells may induce the uptake of HIV by target cells that are endocytosed into trypsin-resistant compartments. We have now compared the mechanism of virus transmission from T cell-to-T cell vers

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::16068f0f69dd3b0ab66b25c20aed0517
https://pubmed.ncbi.nlm.nih.gov/19501262

5-Alkyl-6-benzyl-2-(2-oxo-2-phenylethylsulfanyl)pyrimidin-4(3H)-ones, a series of anti-HIV-1 agents of the dihydro-alkoxy-benzyl-oxopyrimidine family with peculiar structure-activity relationship profile

Autor: Antonello Mai, Giorgia Botta, Boris S. Orlinson, Mercedes Armand-Ugón, M. B. Nawrozkij, Samantha Zanoli, Ira Musmuca, Alberta Samuele, Domenico Tarantino, Dante Rotili, Marino Artico, Giovanni Maga, Alexandre S. Eremiychuk, José A. Esté, Ivan A. Novakov, Rino Ragno, Imma Clotet-Codina

A series of dihydro-alkylthio-benzyl-oxopyrimidines (S-DABOs) bearing a 2-aryl-2-oxoethylsulfanyl chain at pyrimidine C2, an alkyl group at C5, and a 2,6-dichloro-, 2-chloro-6-fluoro-, and 2,6-difluoro-benzyl substitution at C6 (oxophenethyl- S-DABOs

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba78cbc3273ebe54cf40b7a464a3350f
http://hdl.handle.net/11573/363647