Identification of potent and reversible piperidine carboxamides that are species-selective orally active proteasome inhibitors to treat malaria.

Autor: Lawong A; Department of Biochemistry, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75390, USA., Gahalawat S; Department of Biochemistry, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75390, USA., Ray S; Department of Biochemistry, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75390, USA., Ho N; Department of Biochemistry, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75390, USA., Han Y; Department of Biophysics, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75390, USA., Ward KE; Department of Microbiology and Immunology, and Columbia University Irving Medical Center, New York, NY 10032, USA., Deng X; Department of Biochemistry, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75390, USA., Chen Z; Department of Biophysics, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75390, USA., Kumar A; Department of Eugene McDermott Center for Human Growth and Development, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75390, USA., Xing C; Department of Eugene McDermott Center for Human Growth and Development, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75390, USA; Department of Bioinformatics, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75390, USA., Hosangadi V; Department of Microbiology and Immunology, and Columbia University Irving Medical Center, New York, NY 10032, USA., Fairhurst KJ; Department of Microbiology and Immunology, and Columbia University Irving Medical Center, New York, NY 10032, USA., Tashiro K; Department of Biochemistry, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75390, USA., Liszczak G; Department of Biochemistry, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75390, USA., Shackleford DM; Centre for Drug Candidate Optimisation, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, VIC 3052, Australia., Katneni K; Centre for Drug Candidate Optimisation, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, VIC 3052, Australia., Chen G; Centre for Drug Candidate Optimisation, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, VIC 3052, Australia., Saunders J; Centre for Drug Candidate Optimisation, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, VIC 3052, Australia., Crighton E; Centre for Drug Candidate Optimisation, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, VIC 3052, Australia., Casas A; Department of Biochemistry, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75390, USA., Robinson JJ; Department of Biochemistry, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75390, USA., Imlay LS; Department of Biochemistry, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75390, USA., Zhang X; Department of Biochemistry, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75390, USA., Lemoff A; Department of Biochemistry, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75390, USA., Zhao Z; Children's Medical Center Research Institute, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA., Angulo-Barturen I; The Art of Discovery, Biscay Science and Technology Park, Astrondo Bidea, BIC Bizkaia Bd 612, Derio, 48160 Bizkaia, Basque Country, Spain., Jiménez-Díaz MB; The Art of Discovery, Biscay Science and Technology Park, Astrondo Bidea, BIC Bizkaia Bd 612, Derio, 48160 Bizkaia, Basque Country, Spain., Wittlin S; Swiss Tropical and Public Health Institute, 4123 Allschwil, Switzerland; University of Basel Kreuzstrasse 2, 4123 Allschwil, Switzerland., Campbell SF; Medicines for Malaria Venture, 1215 Geneva, Switzerland., Fidock DA; Department of Microbiology and Immunology, and Columbia University Irving Medical Center, New York, NY 10032, USA; Center for Malaria Therapeutics and Antimicrobial Resistance, Division of Infectious Diseases, Columbia University Irving Medical Center, New York, NY 10032, USA., Laleu B; Medicines for Malaria Venture, 1215 Geneva, Switzerland., Charman SA; Centre for Drug Candidate Optimisation, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, VIC 3052, Australia., Ready JM; Department of Biochemistry, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75390, USA. Electronic address: joseph.ready@utsouthwestern.edu., Phillips MA; Department of Biochemistry, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75390, USA. Electronic address: margaret.phillips@utsouthwestern.edu.

Publikováno v: Cell chemical biology [Cell Chem Biol] 2024 Aug 15; Vol. 31 (8), pp. 1503-1517.e19. Date of Electronic Publication: 2024 Jul 30.

Molecular Mechanism of Action of Antimalarial Benzoisothiazolones: Species-Selective Inhibitors of the Plasmodium spp. MEP Pathway enzyme, IspD.

Autor: Price KE; Department of Chemistry, University of Liverpool, Liverpool, L69 7ZD, UK., Armstrong CM; Department of Pediatrics, Washington University School of Medicine, St. Louis, MO 63110, USA., Imlay LS; Department of Pediatrics, Washington University School of Medicine, St. Louis, MO 63110, USA., Hodge DM; Department of Pediatrics, Washington University School of Medicine, St. Louis, MO 63110, USA., Pidathala C; Department of Chemistry, University of Liverpool, Liverpool, L69 7ZD, UK., Roberts NJ; Department of Chemistry, University of Liverpool, Liverpool, L69 7ZD, UK., Park J; Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, MO 63110, USA., Mikati M; Department of Pediatrics, Washington University School of Medicine, St. Louis, MO 63110, USA., Sharma R; Department of Chemistry, University of Liverpool, Liverpool, L69 7ZD, UK., Lawrenson AS; Department of Chemistry, University of Liverpool, Liverpool, L69 7ZD, UK., Tolia NH; Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, MO 63110, USA., Berry NG; Department of Chemistry, University of Liverpool, Liverpool, L69 7ZD, UK., O'Neill PM; Department of Chemistry, University of Liverpool, Liverpool, L69 7ZD, UK., John AR; Department of Pediatrics, Washington University School of Medicine, St. Louis, MO 63110, USA.; Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, MO 63110, USA.

Publikováno v: Scientific reports [Sci Rep] 2016 Nov 18; Vol. 6, pp. 36777. Date of Electronic Publication: 2016 Nov 18.

Plasmodium IspD (2-C-Methyl-D-erythritol 4-Phosphate Cytidyltransferase), an Essential and Druggable Antimalarial Target.

Autor: Imlay LS; Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, Missouri 63110, United States., Armstrong CM; Department of Pediatrics, Washington University School of Medicine, St. Louis, Missouri 63110, United States., Masters MC; Department of Pediatrics, Washington University School of Medicine, St. Louis, Missouri 63110, United States., Li T; College of Medicine, University of Toledo, Toledo, Ohio 43614, United States., Price KE; Department of Chemistry, University of Liverpool, Liverpool L69 7ZD, U.K., Edwards RL; Department of Pediatrics, Washington University School of Medicine, St. Louis, Missouri 63110, United States., Mann KM; Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, Missouri 63110, United States., Li LX; Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, Missouri 63110, United States., Stallings CL; Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, Missouri 63110, United States., Berry NG; Department of Chemistry, University of Liverpool, Liverpool L69 7ZD, U.K., O'Neill PM; Department of Chemistry, University of Liverpool, Liverpool L69 7ZD, U.K., Odom AR; Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, Missouri 63110, United States; Department of Pediatrics, Washington University School of Medicine, St. Louis, Missouri 63110, United States.

Publikováno v: ACS infectious diseases [ACS Infect Dis] 2015 Apr 10; Vol. 1 (4), pp. 157-167. Date of Electronic Publication: 2015 Mar 02.