Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Imke Rudnik-Jansen"'
Publikováno v:
JOR Spine, Vol 7, Iss 3, Pp n/a-n/a (2024)
Abstract Chronic low back pain caused by intervertebral disc (IVD) degeneration, also termed chronic discogenic low back pain (CD‐LBP), is one of the most prevalent musculoskeletal diseases. Degenerative processes in the IVD, such as inflammation a
Externí odkaz:
https://doaj.org/article/9cc793035e3b4f1aba792c94c16ccbda
Autor:
Imke Rudnik-Jansen, Jie Du, Nina Karssemakers-Degen, Anna R. Tellegen, Parvesh Wadhwani, Daniele Zuncheddu, Björn P. Meij, Jens Thies, Pieter Emans, Fetullah C. Öner, George Mihov, Joao Pedro Garcia, Anne S. Ulrich, Sibylle Grad, Marianna A. Tryfonidou, Hugo van Ingen, Laura B. Creemers
Publikováno v:
Drug Delivery, Vol 31, Iss 1 (2024)
Intradiscal drug delivery is a promising strategy for treating intervertebral disk degeneration (IVDD). Local degenerative processes and intrinsically low fluid exchange are likely to influence drug retention. Understanding their connection will enab
Externí odkaz:
https://doaj.org/article/e74ff26b3ae344bf99b69a5fc7b3d7c3
Autor:
Ole A. Mandrup, Sui Ching Ong, Simon Lykkemark, Anders Dinesen, Imke Rudnik-Jansen, Niels Frederik Dagnæs-Hansen, Jan Terje Andersen, Luis Alvarez-Vallina, Kenneth A. Howard
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-11 (2021)
Mandrup et al. describe a panel of recombinant albumin fusions, engineered with different affinities to the human neonatal Fc receptor to program the half-life extension of a bispecific (EGFR/CD3) T-cell engager. They show that this approach generate
Externí odkaz:
https://doaj.org/article/8e9de18872a44db2b4a88a0afeac0789
Autor:
Imke Rudnik-Jansen, Karin Schrijver, Nina Woike, Anna Tellegen, Sabine Versteeg, Pieter Emans, George Mihov, Jens Thies, Niels Eijkelkamp, Marianna Tryfonidou, Laura Creemers
Publikováno v:
Drug Delivery, Vol 26, Iss 1, Pp 226-236 (2019)
Inflammation of the synovium and joint capsule is a main driver of pain in an osteoarthritic (OA) joint. Triamcinolone acetonide (TAA) is a classical corticosteroid that reduces synovitis and alleviates pain, albeit transiently. Biomaterial-based loc
Externí odkaz:
https://doaj.org/article/9e7b74ab86124f0b86ca8010f97063b2
Autor:
Anna Tellegen, Martijn Beukers, Imke Rudnik-Jansen, Nicolien van Klaveren, Kan Loi How, Nina Woike, George Mihov, Jens Thies, Erik Teske, Laura Creemers, Marianna Tryfonidou, Björn Meij
Publikováno v:
Pharmaceutics, Vol 13, Iss 3, p 372 (2021)
Osteoarthritis (OA) is a common cause of pain and disability. Local corticosteroid injections are effective in treating OA pain and inflammation but are short-acting. Prolonged intra-articular (IA) corticosteroid exposure may even lead to cartilage d
Externí odkaz:
https://doaj.org/article/1b2b880f9c2f42448c239744b8b00e1a
Autor:
Joao Pedro Garcia, Lizette Utomo, Imke Rudnik-Jansen, Jie Du, Nicolaas P.A. Zuithoff, Anita Krouwels, Gerjo J.V.M. van Osch, Laura B. Creemers
Publikováno v:
Cells, Vol 10, Iss 3, p 508 (2021)
Pro-inflammatory cytokines are considered to play a major role in osteoarthritis (OA), yet so far, the specific cytokines involved in the pathology of OA have not been identified. Oncostatin M (OSM) is a cytokine from the interleukin 6 (IL-6) family
Externí odkaz:
https://doaj.org/article/e4c6ae6b97194f3abb746383cbab0ec8
Autor:
Imke Rudnik-Jansen, Nina Woike, Suzanne de Jong, Sabine Versteeg, Marja Kik, Pieter Emans, George Mihov, Jens Thies, Niels Eijkelkamp, Marianna Tryfonidou, Laura Creemers
Publikováno v:
Pharmaceutics, Vol 11, Iss 2, p 70 (2019)
Episodes of inflammation and pain are predominant features of arthritic joint diseases. Drug delivery systems (DDS) could reduce inflammation and pain long-term without chances of infection upon multiple injections. To allow for long-term evaluation
Externí odkaz:
https://doaj.org/article/0c9438dc7d7e4f48992300a5adaa807e
Autor:
Elisabeth Fuchs, Imke Rudnik-Jansen, Anders Dinesen, Denis Selnihhin, Ole Aalund Mandrup, Kader Thiam, Jørgen Kjems, Finn Skou Pedersen, Kenneth A. Howard
Publikováno v:
Fuchs, E, Rudnik-Jansen, I, Dinesen, A, Selnihhin, D, Mandrup, O A, Thiam, K, Kjems, J, Pedersen, F S & Howard, K A 2022, ' An albumin-angiotensin converting enzyme 2-based SARS-CoV-2 decoy with FcRn-driven half-life extension ', Acta Biomaterialia, vol. 153, pp. 411-418 . https://doi.org/10.1016/j.actbio.2022.09.048
Fuchs, E, Rudnik-Jansen, I, Dinesen, A, Selnihhin, D, Mandrup, O A, Thiam, K, Kjems, J, Pedersen, F S & Howard, K A 2022, ' An albumin-angiotensin converting enzyme 2-based SARS-CoV-2 decoy with FcRn-driven half-life extension ', Acta Biomaterialia . https://doi.org/10.1016/j.actbio.2022.09.048
Fuchs, E, Rudnik-Jansen, I, Dinesen, A, Selnihhin, D, Mandrup, O A, Thiam, K, Kjems, J, Pedersen, F S & Howard, K A 2022, ' An albumin-angiotensin converting enzyme 2-based SARS-CoV-2 decoy with FcRn-driven half-life extension ', Acta Biomaterialia . https://doi.org/10.1016/j.actbio.2022.09.048
The emergence of new severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) mutants and breakthrough infections despite available coronavirus disease 2019 (COVID-19) vaccines calls for antiviral therapeutics. The application of soluble angioten
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ae37760440459ab869708ad2e060897
https://doi.org/10.1016/j.actbio.2022.09.048
https://doi.org/10.1016/j.actbio.2022.09.048
Autor:
Anders Märcher, Vipin Kumar, Veronica L. Andersen, Kassem El‐Chami, Thuy J. D. Nguyen, Mads K. Skaanning, Imke Rudnik‐Jansen, Jesper S. Nielsen, Kenneth A. Howard, Jørgen Kjems, Kurt V. Gothelf
Publikováno v:
Märcher, A, Kumar, V, Andersen, V L, El-Chami, K, Nguyen, T J D, Skaanning, M K, Rudnik-Jansen, I, Nielsen, J S, Howard, K A, Kjems, J & Gothelf, K V 2022, ' Functionalized Acyclic (l)-Threoninol Nucleic Acid Four-Way Junction with High Stability In Vitro and In Vivo ', Angewandte Chemie-International Edition, vol. 61, no. 24, 202115275 . https://doi.org/10.1002/anie.202115275
Oligonucleotides are increasingly being used as a programmable connection material to assemble molecules and proteins in well-defined structures. For the application of such assemblies for in vivo diagnostics or therapeutics it is crucial that the ol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ce902a59a08814fbc4843125b4c96ca5
https://pure.au.dk/portal/da/publications/functionalized-acyclic-lthreoninol-nucleic-acid-fourway-junction-with-high-stability-in-vitro-and-in-vivo(2c7f5436-6060-4d45-9a07-53de17409047).html
https://pure.au.dk/portal/da/publications/functionalized-acyclic-lthreoninol-nucleic-acid-fourway-junction-with-high-stability-in-vitro-and-in-vivo(2c7f5436-6060-4d45-9a07-53de17409047).html
Autor:
Kenneth A. Howard, Imke Rudnik-Jansen
Publikováno v:
Rudnik-Jansen, I & Howard, K 2021, ' FcRn expression in cancer : Mechanistic basis and therapeutic opportunities ', Journal of Controlled Release, vol. 337, pp. 248-257 . https://doi.org/10.1016/j.jconrel.2021.07.007
There is an urgent need to identify new cellular targets to expand the repertoire, potency and safety of cancer therapeutics. Neonatal Fc Receptor (FcRn)-driven cellular recycling plays a predominant role in the prolonged serum half-life of human ser
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b2fac05e4f636ea25e7772d69178c9c
https://pure.au.dk/ws/files/285209744/1_s2.0_S0168365921003503_main.pdf
https://pure.au.dk/ws/files/285209744/1_s2.0_S0168365921003503_main.pdf