Awareness of HPV-associated oropharyngeal cancers among GPs in The Netherlands: a cross-sectional study

Autor: Imke Demers, Femke Verhees, Leo J Schouten, Jean WM Muris, Bernd Kremer, Ernst Jan M Speel

Publikováno v: BJGP Open, Vol 6, Iss 1 (2022)

Background: The incidence of human papillomavirus (HPV)-associated oropharyngeal cancer (OPC) is increasing in high income countries. HPV-associated OPC generally presents as an invasive disease, often with lymph node involvement, in relatively young

Externí odkaz: https://doaj.org/article/273e8c317b1649f7b5df509f244e7127

Ex Vivo Culture Models to Indicate Therapy Response in Head and Neck Squamous Cell Carcinoma

Autor: Imke Demers, Johan Donkers, Bernd Kremer, Ernst Jan Speel

Publikováno v: Cells, Vol 9, Iss 11, p 2527 (2020)

Head and neck squamous cell carcinoma (HNSCC) is characterized by a poor 5 year survival and varying response rates to both standard-of-care and new treatments. Despite advances in medicine and treatment methods, mortality rates have hardly decreased

Externí odkaz: https://doaj.org/article/c77205f893174948b7bd175646f59a00

Switches of SOX17 and SOX2 expression in the development of squamous metaplasia and squamous intraepithelial lesions of the uterine cervix

Autor: Leendert H. J. Looijenga, Monique Ummelen, Anton N. H. Hopman, Kim A.D. Wouters, Jobran M. Moshi, Imke Demers, Manon van Engeland, Klaas J. Hoogduin, Mieke Henfling, Frans C. S. Ramaekers, Hans Stoop

Publikováno v: Cancer Medicine, Vol 9, Iss 17, Pp 6330-6343 (2020)
Cancer Medicine
Cancer Medicine, 9(17), 6330-6343. Wiley
Cancer Medicine, 9(17), 6330-6343. John Wiley & Sons Ltd.

Aims The dynamics and topographical distribution of SOX17 and SOX2 expression was studied in the transformation zone (TZ) of the uterine cervix. This TZ is a dynamic area where switches from glandular into squamous epithelium can be recognized, new s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::294ce1e481d3fcaa2546b2978d3714b2
https://doaj.org/article/48b7637d65e54d66b12f87f63287acfd

Public awareness of the association between human papillomavirus and oropharyngeal cancer

Autor: Bernd Kremer, Matt Lechner, Ernst-Jan M. Speel, Imke Demers, Leo J. Schouten, Femke Verhees

Publikováno v: European Journal of Public Health, 31(5), 1021-1025. Oxford University Press
The European Journal of Public Health

Background Early diagnosis of human papillomavirus (HPV) associated oropharyngeal cancer (OPC) is associated with improved survival. To achieve early diagnosis, it might be beneficial to increase awareness of the link between HPV and OPC. This increa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bff479a9c95523df7893494f3ee454e2
https://cris.maastrichtuniversity.nl/en/publications/80792c87-b32e-426b-8390-9e19b6e5edd8

Abstract 2573: PI3K/AKT/mTOR pathway and CDK4/6 inhibitors efficiently inhibit cell growth of HPV-positive and HPV-negative head and neck squamous cell carcinoma in vitro

Autor: Imke Demers, Femke Verhees, Dion Leegemaate, Robin Jacobs, Ann Hoeben, Frank Hoebers, Bernd Kremer, Ernst-Jan Speel

Publikováno v: Cancer Research. 82:2573-2573

Introduction: Both HPV-positive and -negative head and neck squamous cell carcinoma (HNSCC) often show activation of the PI3K/AKT/mTOR pathway, due to, amongst others, PI3KCA mutations, PTEN loss, or receptor tyrosine kinase activation. In HPV-negati

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a2e8a8f7d3bdf4af4440fcfe229946a6
https://doi.org/10.1158/1538-7445.am2022-2573