Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Imit Kaur"'
Autor:
Kristina Ames, Imit Kaur, Yang Shi, Meng M. Tong, Taneisha Sinclair, Shayda Hemmati, Shira G. Glushakow-Smith, Ellen Tein, Lindsay Gurska, Ulrich Steidl, Robert Dubin, Jidong Shan, Cristina Montagna, Kith Pradhan, Amit Verma, Kira Gritsman
Publikováno v:
Science Advances. 9
Myelodysplastic syndrome (MDS) is a clonal malignancy arising in hematopoietic stem cells (HSCs). The mechanisms of MDS initiation in HSCs are still poorly understood. The phosphatidylinositol 3-kinase (PI3K)/AKT pathway is frequently activated in ac
Autor:
Ellen Tein, Yang Shi, Kira Gritsman, Shira Glushakow-Smith, Kith Pradhan, Kristina Ames, Imit Kaur, Amit Verma, Robert A. Dubin, Shayda Hemmati, Taneisha Sinclair, Jidong Shan, Lindsay Meg Gurska, Meng Tong, Cristina Montagna
Hematopoietic stem cells (HSCs) maintain the blood system through a delicate equilibrium between self-renewal and differentiation. Most hematopoietic growth factors and cytokines signal through phosphoinositide 3-kinase (PI3K) via three Class IA cata
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3ca84c23de78c74fde32f71f594e149a
https://doi.org/10.1101/2020.12.04.412593
https://doi.org/10.1101/2020.12.04.412593
Autor:
Kira Gritsman, Shira Glushakow-Smith, Yang Shi, Shayda Hemmati, Kith Pradhan, Kristina Ames, Lindsay Meg Gurska, Robert A. Dubin, Amit Verma, Cristina Montagna, Imit Kaur, Jidong Shan
Publikováno v:
Blood. 138:323-323
Myelodysplastic Syndrome (MDS) is a heterogeneous clonal malignancy arising in hematopoietic stem cells (HSCs), characterized by ineffective hematopoiesis, cytopenias, and the potential to progress to acute myeloid leukemia (AML). However, the pertur
Autor:
Meng Tong, Taneisha Sinclair, Anupriya Agarwal, Imit Kaur, Rachel Okabe, Thomas M. Roberts, Boris Bartholdy, Shayda Hemmati, Jean J. Zhao, Leanne Ostrodka, Tamanna Haque, Kristina Ames, Kira Gritsman
Publikováno v:
Molecular Cancer Research. 18:IA18-IA18
The Class IA PI3 kinase isoforms (p110α, β, and δ) transduce many growth factor signals that are important for the proliferation, differentiation, and self-renewal of hematopoietic stem cells (HSCs). Mutations in growth factor receptors or RAS pro
Autor:
Meng Tong, Imit Kaur, Lindsay Meg Gurska, Kristina Ames, Ellen Tein, Kira Gritsman, Shira Glushakow-Smith, Shayda Hemmati
Publikováno v:
Blood. 134:2461-2461
Adult hematopoietic stem cells (HSCs) are a rare and unique population of stem cells that reside in the bone marrow, where they undergo self-renewal and differentiation to maintain the blood system. The maintenance of a proper balance between HSC sel
Autor:
Paul J. Shami, Imit Kaur, Ken M. Kosak, Moises Terrazas, Kenneth M. Boucher, Steven E. Kern, James N. Herron
Publikováno v:
Pharmaceutical Research. 32:1395-1406
O(2)-(2,4-dinitrophenyl)1-[(4-ethoxycarbonyl)piperazin-1-yl]diazen-1-ium-1,2-diolate] or JS-K is a nitric oxide-producing prodrug of the arylated diazeniumdiolate class with promising anti-tumor activity. JS-K has challenging solubility and stability
Autor:
Thomas M. Roberts, Imit Kaur, Shayda Hemmati, Jean J. Zhao, Kristina Ames, Meng Tong, Kira Gritsman, Anupriya Agarwal, Tamanna Haque, Boris Bartholdy, Rachel Okabe, Taneisha Sinclair, Leanne Ostrodka
Publikováno v:
Blood. 132:329-329
Hematopoietic stem cells (HSCs) are a rare population in the bone marrow (BM) that mostly exists in a quiescent state. Upon environmental stresses such as infection, inflammatory signals are released and induce HSCs to proliferate to quickly re-estab
Publikováno v:
Journal of Pharmacy and Pharmacology. 65:1329-1336
Objective Nitric oxide (NO) possesses antitumour activity. It induces differentiation and apoptosis in acute myeloid leukaemia (AML) cells. The NO prodrug O2-(2,4-dinitrophenyl)1-((4-ethoxycarbonyl)piperazin-1-yl)diazen-1-ium-1,2-diolate, or JS-K, ha
Autor:
Ken M. Kosak, Imit Kaur, Catherine M.T. Sherwin, Michael G. Spigarelli, Jonathan E. Constance
Publikováno v:
Expert opinion on drug metabolismtoxicology. 11(1)
Acute myeloid leukemia (AML) is a clonal hematological malignancy characterized by accumulation of poorly differentiated and immature blast cells in bone marrow and blood circulation. The initiation of intensive chemotherapy is necessary to control f
Publikováno v:
Blood. 126:3587-3587
The PI3 kinase (PI3K) signaling pathway is activated by most hematopoietic growth factors and chemokines that orchestrate normal adult hematopoiesis. Hematopoietic cells express four different catalytic isoforms of PI3K (p110α, β, δ, and γ), each