Screening and characterization of a diverse panel of metagenomic imine reductases for biocatalytic reductive amination

Autor: James R. Marshall, Darren J. Cook, Peiyuan Yao, Nicholas J. Turner, Kirsty M. Graham, Richard A. M. Duncan, Juan Mangas-Sanchez, Simon J. Charnock, Sarah L. Montgomery, Rachel S. Heath, Ryan B. Palmer, Thomas W. Thorpe, James Finnigan

Publikováno v: Nat Chem
Nature Chemistry
Marshall, J R, Yao, P, Montgomery, S L, Finnigan, J D, Thorpe, T W, Palmer, R B, Mangas-sanchez, J, Duncan, R A M, Heath, R S, Graham, K M, Cook, D J, Charnock, S J & Turner, N J 2020, ' Screening and characterization of a diverse panel of metagenomic imine reductases for biocatalytic reductive amination ', Nature Chemistry, vol. 13, no. 2, 0, pp. 140-148 . https://doi.org/10.1038/s41557-020-00606-w

Finding faster and simpler ways to screen protein sequence space to enable the identification of new biocatalysts for asymmetric synthesis remains both a challenge and a rate-limiting step in enzyme discovery. Biocatalytic strategies for the synthesi

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https://pubmed.ncbi.nlm.nih.gov/33380742