Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Imene Hamaidi"'
Autor:
Rana Falahat, Anders Berglund, Patricio Perez-Villarroel, Ryan M. Putney, Imene Hamaidi, Sungjune Kim, Shari Pilon-Thomas, Glen N. Barber, James J. Mulé
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-16 (2023)
STING agonists have shown limited efficacy in early-phase clinical trials despite promising pre-clinical data. This study shows the potential clinical relevance of the use of combination STING agonists and demethylating agent therapies to induce the
Externí odkaz:
https://doaj.org/article/037d3d2b0f6a4fe2abca22ce25387f4d
Autor:
Mélanie Mahe, Florent Dufour, Hélène Neyret‐Kahn, Aura Moreno‐Vega, Claire Beraud, Mingjun Shi, Imene Hamaidi, Virginia Sanchez‐Quiles, Clementine Krucker, Marion Dorland‐Galliot, Elodie Chapeaublanc, Remy Nicolle, Hervé Lang, Celio Pouponnot, Thierry Massfelder, François Radvanyi, Isabelle Bernard‐Pierrot
Publikováno v:
EMBO Molecular Medicine, Vol 10, Iss 4, Pp 1-18 (2018)
Abstract FGFR3 alterations (mutations or translocation) are among the most frequent genetic events in bladder carcinoma. They lead to an aberrant activation of FGFR3 signaling, conferring an oncogenic dependence, which we studied here. We discovered
Externí odkaz:
https://doaj.org/article/1ed43450adb6412f8cc0a5fba9c79f14
Autor:
Sungjune, Kim, Evan, Wuthrick, Dukagjin, Blakaj, Zeynep, Eroglu, Claire, Verschraegen, Ram, Thapa, Matthew, Mills, Khaled, Dibs, Casey, Liveringhouse, Jeffery, Russell, Jimmy J, Caudell, Ahmad, Tarhini, Joseph, Markowitz, Kari, Kendra, Richard, Wu, Dung-Tsa, Chen, Anders, Berglund, Lauren, Michael, Mia, Aoki, Min-Hsuan, Wang, Imene, Hamaidi, Pingyan, Cheng, Janis, de la Iglesia, Robbert J, Slebos, Christine H, Chung, Todd C, Knepper, Carlos M, Moran-Segura, Jonathan V, Nguyen, Bradford A, Perez, Trevor, Rose, Louis, Harrison, Jane L, Messina, Vernon K, Sondak, Kenneth Y, Tsai, Nikhil I, Khushalani, Andrew S, Brohl
Publikováno v:
The Lancet. 400:1008-1019
Merkel cell carcinoma is among the most aggressive and lethal of primary skin cancers, with a high rate of distant metastasis. Anti-programmed death receptor 1 (anti-PD-1) and programmed death ligand 1 (PD-L1) monotherapy is currently standard of car
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ff9df26b4880352871546d5e6155e205
https://doi.org/10.1016/s0140-6736(22)01659-2
https://doi.org/10.1016/s0140-6736(22)01659-2
Autor:
Imene Hamaidi, Sungjune Kim
Publikováno v:
Experimentalmolecular medicine. 54(3)
It is well known that metabolism underlies T cell differentiation and functions. The pathways regulating T cell metabolism and function are interconnected, and changes in T cell metabolic activity directly impact the effector functions and fate of T
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4dd9868b110474b8a8650605039a9f10
https://pubmed.ncbi.nlm.nih.gov/35296782
https://pubmed.ncbi.nlm.nih.gov/35296782
Publikováno v:
Experimental & Molecular Medicine
Cancer immune evasion is one of the hallmarks of carcinogenesis. Cancer cells employ multiple mechanisms to avoid immune recognition and suppress antitumor immune responses. Recently, accumulating evidence has indicated that immune-related pathways a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6db52e0abe95ec76ec0f646866d91966
https://pubmed.ncbi.nlm.nih.gov/33963293
https://pubmed.ncbi.nlm.nih.gov/33963293
Autor:
Scott J. Antonia, Robert W. Engelman, Sungjune Kim, Min Liu, Jiqiang Yao, Anders Berglund, John M. Koomen, James J. Mulé, Ben C. Creelan, Min-Hsuan Wang, Nayoung Kim, Bin Fang, Lin Zhang, Jose R. Conejo-Garcia, Cristina Iclozan, Imene Hamaidi, Sean Yoder
Publikováno v:
Regular and young investigator award abstracts.
Background The majority of cancer patients remain refractory to existing cancer immunotherapies. Despite the growing evidence that dysregulated metabolism contributes to the exhaustion of tumor-infiltrating T lymphocytes (TILs) and the loss of their
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::572f50c5c9a3a715792e5f8d61031612
https://doi.org/10.1136/jitc-2020-sitc2020.0093
https://doi.org/10.1136/jitc-2020-sitc2020.0093
Publikováno v:
Journal for ImmunoTherapy of Cancer. 9:A952-A952
BackgroundCancer immunotherapy represents a major paradigm shift in cancer care. Despite such breakthrough, majority of cancer patients remains refractory to existing immunotherapeutic modalities highlighting the inherent capacity of tumors to escape
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::295f4c88f93b399605c4290c17faee46
https://doi.org/10.1136/jitc-2021-sitc2021.907
https://doi.org/10.1136/jitc-2021-sitc2021.907
Autor:
Ben C. Creelan, Lin Zhang, Nayoung Kim, Anders Berglund, John M. Koomen, Scott J. Antonia, Sungjune Kim, Sean J. Yoder, Robert W. Engelman, Jose R. Conejo-Garcia, Jiqiang Yao, Min Hsuan Wang, James J. Mulé, Imene Hamaidi, Min Liu, Bin Fang, Cristina Iclozan
Publikováno v:
Cancer Research. 81:1635-1635
Background: The majority of cancer patients remain refractory to existing cancer immunotherapies. Despite the growing evidence that dysregulated metabolism contributes to the exhaustion of tumor-infiltrating T lymphocytes (TILs) and the loss of their
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a39a65cb2db212d68a0e9c6e36ecec16
https://doi.org/10.1158/1538-7445.am2021-1635
https://doi.org/10.1158/1538-7445.am2021-1635
Autor:
Min-Hsuan Wang, Ben C. Creelan, Lin Zhang, Cristina Iclozan, Bin Fang, Imene Hamaidi, Robert W. Engelman, Min Liu, Nayoung Kim, Anders Berglund, Scott J. Antonia, James J. Mulé, Sungjune Kim, Sean J. Yoder, Jose R. Conejo-Garcia, John M. Koomen, Jiqiang Yao
Publikováno v:
Cell Metab
Summary Dysregulated metabolism is a key driver of maladaptive tumor-reactive T lymphocytes within the tumor microenvironment. Actionable targets that rescue the effector activity of antitumor T cells remain elusive. Here, we report that the Sirtuin-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d7cb4e5da940e9a53fcf7723f587de6
https://doi.org/10.1016/j.cmet.2020.07.008
https://doi.org/10.1016/j.cmet.2020.07.008