Enzymatic and Molecular Characterization of Anti-Leishmania Molecules That Differently Target Leishmania and Mammalian eIF4A Proteins, LieIF4A and eIF4AMus

Autor: Yosser Zina Abdelkrim, Emna Harigua-Souiai, Imen Bassoumi-Jamoussi, Mourad Barhoumi, Josette Banroques, Khadija Essafi-Benkhadir, Michael Nilges, Arnaud Blondel, N. Kyle Tanner, Ikram Guizani

Publikováno v: Molecules, Vol 27, Iss 18, p 5890 (2022)

Previous investigations of the Leishmania infantum eIF4A-like protein (LieIF4A) as a potential drug target delivered cholestanol derivatives inhibitors. Here, we investigated the mode of action of cholesterol derivatives as a novel scaffold structure

Externí odkaz: https://doaj.org/article/dd3b2dc394d34a8a8f9fc27de5aab333

Identification of novel leishmanicidal molecules by virtual and biochemical screenings targeting Leishmania eukaryotic translation initiation factor 4A

Autor: Imen Bassoumi-Jamoussi, Guillaume Bouvier, Michael Nilges, Mourad Barhoumi, N. Kyle Tanner, Josette Banroques, Arnaud Blondel, Ikram Guizani, Nathan Desdouits, Khadija Essafi-Benkhadir, Hélène Munier-Lehmann, Emna Harigua-Souiai, Yosser Zina Abdelkrim, Ons Zakraoui

Publikováno v: PLoS Neglected Tropical Diseases
PLoS Neglected Tropical Diseases, Public Library of Science, 2018, 12 (1), pp.e0006160. ⟨10.1371/journal.pntd.0006160⟩
PLoS Neglected Tropical Diseases, 2018, 12 (1), pp.e0006160. ⟨10.1371/journal.pntd.0006160⟩
PLoS Neglected Tropical Diseases, Vol 12, Iss 1, p e0006160 (2018)

Leishmaniases are neglected parasitic diseases in spite of the major burden they inflict on public health. The identification of novel drugs and targets constitutes a research priority. For that purpose we used Leishmania infantum initiation factor 4

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0672f598131f3a814de19e5a2c66f228
https://hal-pasteur.archives-ouvertes.fr/pasteur-01968424

Asteraceae Artemisia campestris and Artemisia herba-alba Essential Oils Trigger Apoptosis and Cell Cycle Arrest in Leishmania infantum Promastigotes

Autor: Meriam Haoues, H. Karoui, Khadija Essafi-Benkhadir, Imen Bassoumi Jamoussi, Noura Neffati, Mohamed Boussaid, Zohra Aloui, Chokri Messaoud, Ikram Guizani

Publikováno v: Evidence-Based Complementary and Alternative Medicine
Evidence-Based Complementary and Alternative Medicine, Hindawi Publishing Corporation, 2016, 2016, pp.9147096. ⟨10.1155/2016/9147096⟩
Evidence-Based Complementary and Alternative Medicine, Vol 2016 (2016)

We report the chemical composition and anti-Leishmaniaand antioxidant activity ofArtemisia campestrisL. andArtemisia herba-albaAsso. essential oils (EOs). Our results showed that these extracts exhibit different antioxidant activities according to th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7eeeb6041c3a13a331d782089255e743
https://hal-riip.archives-ouvertes.fr/pasteur-01446819/document