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Genetic analysis of isoform usage in the human anti-viral response reveals influenza-specific regulation of ERAP2 transcripts under balancing selection.

Autor: Ye CJ; Institute for Human Genetics, Institute for Health and Computational Sciences, Department of Biostatistics and Epidemiology, Department of Bioengineering and Therapeutic Sciences, University of California, San Francisco, California 94143, USA., Chen J; Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02142, USA.; Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA., Villani AC; Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02142, USA.; Department of Medicine, Massachusetts General Hospital Cancer Center, Boston, Massachusetts 02114, USA., Gate RE; Institute for Human Genetics, Institute for Health and Computational Sciences, Department of Biostatistics and Epidemiology, Department of Bioengineering and Therapeutic Sciences, University of California, San Francisco, California 94143, USA.; Biomedical Informatics Program, University of California, San Francisco, California 94143, USA., Subramaniam M; Institute for Human Genetics, Institute for Health and Computational Sciences, Department of Biostatistics and Epidemiology, Department of Bioengineering and Therapeutic Sciences, University of California, San Francisco, California 94143, USA.; Biomedical Informatics Program, University of California, San Francisco, California 94143, USA., Bhangale T; Genentech Incorporated, South San Francisco, California 94080, USA., Lee MN; Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02142, USA.; Department of Medicine, Massachusetts General Hospital Cancer Center, Boston, Massachusetts 02114, USA.; Harvard Medical School, Boston, Massachusetts 02116, USA., Raj T; Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02142, USA.; Harvard Medical School, Boston, Massachusetts 02116, USA.; Departments of Neurology and Psychiatry, Brigham and Women's Hospital, Boston, Massachusetts 02115, USA., Raychowdhury R; Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02142, USA., Li W; Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02142, USA., Rogel N; Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02142, USA., Simmons S; Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02142, USA., Imboywa SH; Harvard Medical School, Boston, Massachusetts 02116, USA., Chipendo PI; Harvard Medical School, Boston, Massachusetts 02116, USA., McCabe C; Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02142, USA.; Departments of Neurology and Psychiatry, Brigham and Women's Hospital, Boston, Massachusetts 02115, USA., Lee MH; Harvard Medical School, Boston, Massachusetts 02116, USA., Frohlich IY; Harvard Medical School, Boston, Massachusetts 02116, USA., Stranger BE; Section of Genetic Medicine, Department of Medicine, Institute for Genomics and Systems Biology, Center for Data Intensive Science, The University of Chicago, Chicago, Illinois 60637, USA., De Jager PL; Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02142, USA.; Harvard Medical School, Boston, Massachusetts 02116, USA.; Departments of Neurology and Psychiatry, Brigham and Women's Hospital, Boston, Massachusetts 02115, USA., Regev A; Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02142, USA.; Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA.; Howard Hughes Medical Institute, Chevy Chase, Maryland 20815, USA., Behrens T; Genentech Incorporated, South San Francisco, California 94080, USA., Hacohen N; Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02142, USA.; Department of Medicine, Massachusetts General Hospital Cancer Center, Boston, Massachusetts 02114, USA.

Publikováno v: Genome research [Genome Res] 2018 Dec; Vol. 28 (12), pp. 1812-1825. Date of Electronic Publication: 2018 Nov 16.

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Akademický článek

Dissecting the role of non-coding RNAs in the accumulation of amyloid and tau neuropathologies in Alzheimer's disease.

Autor: Patrick E; Departments of Neurology and Psychiatry, Brigham and Women's Hospital, Program in Translational NeuroPsychiatric Genomics, Institute for the Neurosciences, 77 Avenue Louis Pasteur, NRB 168C, Boston, MA, 02115, USA.; Harvard Medical School, Boston, MA, USA.; Program in Medical and Population Genetics, Broad Institute, Cambridge, MA, USA., Rajagopal S; Departments of Neurology and Psychiatry, Brigham and Women's Hospital, Program in Translational NeuroPsychiatric Genomics, Institute for the Neurosciences, 77 Avenue Louis Pasteur, NRB 168C, Boston, MA, 02115, USA.; Harvard Medical School, Boston, MA, USA.; Program in Medical and Population Genetics, Broad Institute, Cambridge, MA, USA., Wong HA; Departments of Neurology, Brigham and Women's Hospital, Boston, MA, USA., McCabe C; Program in Medical and Population Genetics, Broad Institute, Cambridge, MA, USA., Xu J; Departments of Neurology and Psychiatry, Brigham and Women's Hospital, Program in Translational NeuroPsychiatric Genomics, Institute for the Neurosciences, 77 Avenue Louis Pasteur, NRB 168C, Boston, MA, 02115, USA.; Harvard Medical School, Boston, MA, USA.; Program in Medical and Population Genetics, Broad Institute, Cambridge, MA, USA., Tang A; Departments of Neurology and Psychiatry, Brigham and Women's Hospital, Program in Translational NeuroPsychiatric Genomics, Institute for the Neurosciences, 77 Avenue Louis Pasteur, NRB 168C, Boston, MA, 02115, USA.; Program in Medical and Population Genetics, Broad Institute, Cambridge, MA, USA., Imboywa SH; Departments of Neurology, Brigham and Women's Hospital, Boston, MA, USA., Schneider JA; Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL, USA., Pochet N; Departments of Neurology and Psychiatry, Brigham and Women's Hospital, Program in Translational NeuroPsychiatric Genomics, Institute for the Neurosciences, 77 Avenue Louis Pasteur, NRB 168C, Boston, MA, 02115, USA.; Harvard Medical School, Boston, MA, USA.; Program in Medical and Population Genetics, Broad Institute, Cambridge, MA, USA., Krichevsky AM; Departments of Neurology, Brigham and Women's Hospital, Boston, MA, USA., Chibnik LB; Departments of Neurology and Psychiatry, Brigham and Women's Hospital, Program in Translational NeuroPsychiatric Genomics, Institute for the Neurosciences, 77 Avenue Louis Pasteur, NRB 168C, Boston, MA, 02115, USA.; Harvard Medical School, Boston, MA, USA.; Program in Medical and Population Genetics, Broad Institute, Cambridge, MA, USA., Bennett DA; Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL, USA., De Jager PL; Departments of Neurology and Psychiatry, Brigham and Women's Hospital, Program in Translational NeuroPsychiatric Genomics, Institute for the Neurosciences, 77 Avenue Louis Pasteur, NRB 168C, Boston, MA, 02115, USA. pdejager@rics.bwh.harvard.edu.; Harvard Medical School, Boston, MA, USA. pdejager@rics.bwh.harvard.edu.; Program in Medical and Population Genetics, Broad Institute, Cambridge, MA, USA. pdejager@rics.bwh.harvard.edu.

Publikováno v: Molecular neurodegeneration [Mol Neurodegener] 2017 Jul 01; Vol. 12 (1), pp. 51. Date of Electronic Publication: 2017 Jul 01.

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