Výsledky vyhledávání - "Imania Powers"

Akademický článek

Multivalent interactions between molecular components involved in fast endophilin mediated endocytosis drive protein phase separation

Autor: Samsuzzoha Mondal, Karthik Narayan, Samuel Botterbusch, Imania Powers, Jason Zheng, Honey Priya James, Rui Jin, Tobias Baumgart

Publikováno v: Nature Communications, Vol 13, Iss 1, Pp 1-20 (2022)

Here the authors show that protein phase separation is a key mechanism in cellular receptor internalization via fast endophilin mediated endocytosis (FEME). Phase separation facilitates multivalent FEME-protein assembly in this clathrin-independent p

Externí odkaz: https://doaj.org/article/eb88be9e379b4997bb94720b21511499

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Multivalent Interactions between Molecular Components Involved in Fast Endophilin Mediated Endocytosis Drive Protein Phase Separation

Autor: Samsuzzoha Mondal, Karthik Narayan, Samuel Botterbusch, Imania Powers, Jason Zheng, Honey Priya James, Rui Jin, Tobias Baumgart

A specific group of transmembrane receptors, including the β1-adrenergic receptor (β1-AR), is internalized through a non-clathrin pathway known as Fast Endophilin Mediated Endocytosis (FEME). A key question is: how does the endocytic machinery asse

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::16f0f5f80498fb7bbfc19cd19914c1f0
https://doi.org/10.1101/2021.12.27.474257

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Endophilin Recruitment via GPCR Interactions Enables Membrane Curvature Generation in the Absence of Anionic Lipids

Autor: Imania Powers, Samuel Botterbusch, Karthik B. Narayan, Tobias Baumgart, Samsuzzoha Mondal

The Bin/Amphiphysin/Rvs (BAR) family protein endophilin plays key roles in membrane curvature generation during endocytosis of cellular receptors. The Src homology 3 (SH3) domain of endophilin interacts with the proline rich third intracellular loop

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c37a30bc1e356e0589705b26eab12566
https://doi.org/10.1101/2020.07.11.198937

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Multivalent interactions between molecular components involved in non-clathrin endocytosis drive protein phase separation

Autor: Samsuzzoha Mondal, Samuel Botterbusch, Karthik Narayan, Imania Powers, Jason Zheng, Tobias Baumgart

Publikováno v: Biophysical Journal. 121:80a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a5ec277f02e609974301b3876ee17df1
https://doi.org/10.1016/j.bpj.2021.11.2319

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Endophilin recruitment drives membrane curvature generation through coincidence detection of GPCR loop interactions and negative lipid charge

Autor: Samsuzzoha Mondal, Samuel Botterbusch, Tobias Baumgart, Imania Powers, Karthik B. Narayan

Publikováno v: The Journal of Biological Chemistry

Endophilin plays key roles during endocytosis of cellular receptors, including generating membrane curvature to drive internalization. Electrostatic interactions between endophilin’s BIN/Amphiphysin/Rvs domain and anionic membrane lipids have been

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3c40bd9fd7734e426564856243dc5cb7
https://doi.org/10.1074/jbc.ra120.016118

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