Zobrazeno 1 - 1
of 1
pro vyhledávání: '"Imane Zoubaa"'
Autor:
Florence Meyer-Losic, Fabien Ribes, Valérie Arranz, Jean-Sébastien Fruchart, Imane Zoubaa, Vincent Dubois, Céline Nicolazzi, Jonathan Kearsey, Denis Ravel, Matthieu Michel, Catherine de Coupade, Matthieu Boukaissi, Anne-Sophie Chéné, Jérôme Quinonero, Isabelle Tranchant
Publikováno v:
Clinical cancer research : an official journal of the American Association for Cancer Research. 14(7)
Purpose: Irinotecan is a prodrug converted to the active cytotoxic molecule SN38 predominantly by the action of liver carboxylesterases. The efficacy of irinotecan is limited by this hepatic activation that results in a low conversion rate, high inte