Ginkgo biloba extract increases neurite outgrowth and activates the Akt/mTOR pathway.

Autor: Imane Lejri, Amandine Grimm, Anne Eckert

Publikováno v: PLoS ONE, Vol 14, Iss 12, p e0225761 (2019)

BackgroundStandardized Ginkgo biloba extract (GBE) has demonstrated efficacy in the cognitive functional neuropsychiatric symptoms of patients with Alzheimer's disease (AD). With regard to its underlying molecular mode of action, first evidence was p

Externí odkaz: https://doaj.org/article/01740af05d0a44ff861279f211628022

Clock-Controlled Mitochondrial Dynamics Correlates with Cyclic Pregnenolone Synthesis

Autor: Melissa Witzig, Amandine Grimm, Karen Schmitt, Imane Lejri, Stephan Frank, Steven A. Brown, Anne Eckert

Publikováno v: Cells, Vol 9, Iss 10, p 2323 (2020)

Neurosteroids are steroids synthetized in the nervous system, with the first step of steroidogenesis taking place within mitochondria with the synthesis of pregnenolone. They exert important brain-specific functions by playing a role in neurotransmis

Externí odkaz: https://doaj.org/article/ea9f8542d6fd44e2a304a28967a92bf9

Spermidine Rescues Bioenergetic and Mitophagy Deficits Induced by Disease-Associated Tau Protein

Autor: Lauren H. Fairley, Imane Lejri, Amandine Grimm, Anne Eckert

Publikováno v: International Journal of Molecular Sciences; Volume 24; Issue 6; Pages: 5297

Abnormal tau build-up is a hallmark of Alzheimer’s disease (AD) and more than 20 other serious neurodegenerative diseases. Mitochondria are paramount organelles playing a predominant role in cellular bioenergetics, namely by providing the main sour

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d846233fa650ac9380997d6b9124ae14
https://doi.org/10.3390/ijms24065297

Aerobic Exercise and Stretching as Add-On to Inpatient Treatment for Depression Have No Differential Effects on Stress-Axis Activity, Serum-BDNF, TNF-Alpha and Objective Sleep Measures

Autor: Uwe Pühse, Anne Eckert, Christian Imboden, Martin Hatzinger, Markus Gerber, Imane Lejri, Johannes Beck, Edith Holsboer-Trachsler

Publikováno v: Brain Sciences
Brain Sciences, Vol 11, Iss 411, p 411 (2021)
Volume 11
Issue 4

(1) Background: While the antidepressant effects of aerobic exercise (AE) are well documented, fewer studies have examined impact of AE as an add-on treatment. Moreover, various effects on neurobiological variables have been suggested. This study exa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a455e1d6d262ed1340789a61d5af3d4
https://pubmed.ncbi.nlm.nih.gov/33805073

Influence of Regular Physical Activity on Mitochondrial Activity and Symptoms of Burnout - An Interventional Pilot Study

Autor: Serge Brand, Markus Gerber, Anne Eckert, Katarina Ebner, Thorsten Mikoteit, Edith Holsboer-Trachsler, Imane Lejri, Johannes Beck

Publikováno v: Journal of Clinical Medicine
Journal of Clinical Medicine; Volume 9; Issue 3; Pages: 667
Journal of Clinical Medicine, Vol 9, Iss 3, p 667 (2020)

Background: Occupational burnout is both a serious public and individual health concern. Psychopharmacological and psychological interventions are often employed, while interventions involving physical activity have been less frequently studied. The

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::64d493acf238e7f0d98827bd7cd235dd
https://edoc.unibas.ch/77129/