Výsledky vyhledávání - "Imane Ghafir El Idrissi"

Akademický článek

Multitarget-Directed Ligands Hitting Serotonin Receptors: A Medicinal Chemistry Survey

Autor: Imane Ghafir El Idrissi, Angela Santo, Enza Lacivita, Marcello Leopoldo

Publikováno v: Pharmaceuticals, Vol 17, Iss 9, p 1238 (2024)

Serotonin (5-hydroxytryptamine, 5-HT) is a ubiquitous neurotransmitter in the human body. In the central nervous system, 5-HT affects sleep, pain, mood, appetite, and attention, while in the peripheral nervous system, 5-HT modulates peristalsis, mucu

Externí odkaz: https://doaj.org/article/4111d15bed8547cabd7a758ceca6537e

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Akademický článek

Microglia Depletion Attenuates the Pro-Resolving Activity of the Formyl Peptide Receptor 2 Agonist AMS21 Related to Inhibition of Inflammasome NLRP3 Signalling Pathway: A Study of Organotypic Hippocampal Cultures

Autor: Kinga Tylek, Ewa Trojan, Monika Leśkiewicz, Imane Ghafir El Idrissi, Enza Lacivita, Marcello Leopoldo, Agnieszka Basta-Kaim

Publikováno v: Cells, Vol 12, Iss 21, p 2570 (2023)

Microglial cells have been demonstrated to be significant resident immune cells that maintain homeostasis under physiological conditions. However, prolonged or excessive microglial activation leads to disturbances in the resolution of inflammation (R

Externí odkaz: https://doaj.org/article/4f8a9ab872b44c05b7da50007e97f28f

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Akademický článek

Liquid Biopsy beyond Cancer: A miRNA Detection in Serum with Electrochemical Chip for Non‐Invasive Coeliac Disease Diagnosis

Autor: Veronica Caratelli, Maria Moccia, Francesca R. Paggioro, Luca Fiore, Concetta Avitabile, Michele Saviano, Anna Lisa Imbriani, Principia Dardano, Luca De Stefano, Danila Moscone, Nicola A. Colabufo, Imane Ghafir El Idrissi, Francesco Russo, Giuseppe Riezzo, Gianluigi Giannelli, Fabiana Arduini

Publikováno v: Advanced NanoBiomed Research, Vol 2, Iss 9, Pp n/a-n/a (2022)

Coeliac disease is a very common autoimmune disease estimated to affect 1 in 100 people worldwide. It occurs in genetically predisposed people where the ingestion of gluten leads to damage in the small intestine, and it is accurately diagnosticated t

Externí odkaz: https://doaj.org/article/a9d11e4ea8c64fca9d6491eb185d70c2

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Akademický článek

miRNAs for the Detection of MultiDrug Resistance: Overview and Perspectives

Autor: Andreas Gisel, Mirna Valvano, Imane Ghafir El Idrissi, Patrizia Nardulli, Amalia Azzariti, Antonio Carrieri, Marialessandra Contino, Nicola Antonio Colabufo

Publikováno v: Molecules, Vol 19, Iss 5, Pp 5611-5623 (2014)

The goal of the present paper is to establish and validate the link between cancer diagnosis and therapy by microRNAs detection. The induction in vitro of some specific microRNAs after treatment with MDR ligands has been outlined. Starting from the r

Externí odkaz: https://doaj.org/article/f8ff3e4b859448908e0ddd58680bb110

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Structure-Activity Relationships and Therapeutic Potential of Purinergic P2X7 Receptor Antagonists

Autor: Enza Lacivita, Imane Ghafir El Idrissi, Sabina Podlewska, Carmen Abate, Andrzej J. Bojarski, Marcello Leopoldo

Publikováno v: Current Medicinal Chemistry. 30

Abstract: The purinergic P2X7 receptor (P2X7R), an ATP-gated non-selective cation channel, has emerged as a gatekeeper of inflammation that controls the release of pro-inflammatory cytokines. As a key player in initiating the inflammatory signaling c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::64b0e93bb9da58ecd36631798c5eb83f
https://doi.org/10.2174/0929867330666230403094538

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Amyloid binding and beyond: a new approach for Alzheimer's disease drug discovery targeting Aβo–PrPCbinding and downstream pathways

Publikováno v: Chemical Science. 12:3768-3785

Amyloid β oligomers (Aβo) are the main toxic species in Alzheimer's disease, which have been targeted for single drug treatment with very little success. In this work we report a new approach for identifying functional Aβo binding compounds. A tai

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::04daccd30e1189b255839170ec5be975
https://doi.org/10.1039/d0sc04769d

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Glucosylpolyphenols as Inhibitors of Aβ-Induced Fyn Kinase Activation and Tau Phosphorylation: Synthesis, Membrane Permeability, and Exploratory Target Assessment within the Scope of Type 2 Diabetes and Alzheimer's Disease

Publikováno v: Journal of medicinal chemistry. 63(20)

Despite the rapidly increasing number of patients suffering from type 2 diabetes, Alzheimer's disease, and diabetes-induced dementia, there are no disease-modifying therapies that are able to prevent or block disease progress. In this work, we invest

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2955ff1d8fc358a444cb9a611bea615b
https://pubmed.ncbi.nlm.nih.gov/32959649

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Discovery of N-methylpiperazinyl flavones as a novel class of compounds with therapeutic potential against Alzheimer’s disease : synthesis, binding affinity towards amyloid β oligomers (Aβo) and ability to disrupt Aβo-PrPC interactions

Autor: David A. Evans, Benjamin M. Partridge, James H. Grayson, Emma Mead, Claire J. Garwood, Amélia P. Rauter, Teresa Man, Cleide C. Souza, Beining Chen, Imane Ghafir El Idrissi, Ke Ning, Maria Cristina Oliveira, Ana M. Matos, Gary Sharman, Joanna Wolak, Charlotte Dunbar

With no currently available disease-modifying drugs, Alzheimer’s disease is the most common type of dementia affecting over 47 million people worldwide. In light of the most recent discoveries placing the cellular prion protein (PrPC) as a key play

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa463a554c9c54853feeb04e0204b91d

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Non-Ceruloplasmin Copper Distincts Subtypes in Alzheimer’s Disease: a Genetic Study of ATP7B Frequency

Autor: Rosanna Squitti, Nicola Antonio Colabufo, Serena Bucossi, Chiara Congiu, Mariacarla Ventriglia, Stefania Mariani, Cristian Bonvicini, Imane Ghafir El Idrissi, Orazio Zanetti, Paolo Maria Rossini, Mauro Rongioletti, Massimo Gennarelli

Meta-analyses show that serum copper non-bound-to-ceruloplasmin (non-Cp-Cu) is higher in patients with Alzheimer’s disease (AD). ATP7B gene variants associate with AD, modulating the size of non-Cp-Cu pool. However, a dedicated genetic study compar

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b755a117215cf765ccf5d97be3a3aabd
http://hdl.handle.net/11379/489876

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Measurements of serum non-ceruloplasmin copper by a direct fluorescent method specific to Cu(II)

Autor: Mariacristina Siotto, Imane Ghafir El Idrissi, Nicola Antonio Colabufo, Rosanna Squitti, Emanuele Cassetta

Publikováno v: Clinical chemistry and laboratory medicine. 55(9)

Background:Meta-analyses indicated the breakdown of copper homeostasis in the sporadic form of Alzheimer’s disease (AD), comprising copper decreases within the brain and copper increases in the blood and the pool not bound to ceruloplasmin (non-Cp

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::768d9a57a26aca39dfa9f1ef984f3c08
https://pubmed.ncbi.nlm.nih.gov/28076308

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