Výsledky vyhledávání - "Iman Halloum"

Akademický článek

Mycobacterium abscessus-Induced Granuloma Formation Is Strictly Dependent on TNF Signaling and Neutrophil Trafficking.

Autor: Audrey Bernut, Mai Nguyen-Chi, Iman Halloum, Jean-Louis Herrmann, Georges Lutfalla, Laurent Kremer

Publikováno v: PLoS Pathogens, Vol 12, Iss 11, p e1005986 (2016)

Mycobacterium abscessus is considered the most common respiratory pathogen among the rapidly growing non-tuberculous mycobacteria. Infections with M. abscessus are increasingly found in patients with chronic lung diseases, especially cystic fibrosis,

Externí odkaz: https://doaj.org/article/584011b9d3d54727829bbd1322fe74d0

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Cigarette smoke interacts with amiodarone toxicity in Saccharomyces cerevisiae

Autor: Houssein Al‐Attrache, Iman Halloum, Lara Hammoud, Katia El Ghoz, Ziad Abdel‐Razzak

Publikováno v: Journal of Applied Toxicology. 43:764-768

Amiodarone (AMD) is an antiarrhythmic drug prescribed to treat ventricular tachycardia and fibrillation. However, it causes an unpredictable toxicity (idiosyncratic), which may depend on co-exposure to pollutants. AMD toxicity involves calcium homeos

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4cb287b680644d2f62b7f314a7f32150
https://doi.org/10.1002/jat.4413

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Dose-dependent interaction of two heavy metals with amiodarone toxicity in

Autor: Iman, Halloum, Houssein, Al-Attrache, Katia, El-Ghoz, Lara, Hammoud, Ziad, Abdel-Razzak

Publikováno v: Toxicology and industrial health. 38(5)

Amiodarone (AMD) is an antiarrhythmic drug that induces idiosyncratic toxicity. Environmental pollutants, including heavy metals, could interact with its toxicity by affecting pharmacokinetics and pharmacodynamics. Other levels of interaction could e

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::6eec6486193f41bde4e6ea940bd5efa2
https://pubmed.ncbi.nlm.nih.gov/35513769

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The endogenous galactofuranosidase GlfH1 hydrolyzes mycobacterial arabinogalactan

Autor: Albertus Viljoen, Yann Guérardel, Alexandre Mery, Maju Joe, Laurent Kremer, Sydney A. Villaume, Emeline Fabre, Christophe Mariller, Kaoru Takegawa, Stéphane P. Vincent, Lin Shen, Todd L. Lowary, Iman Halloum, Loïc P. Chêne

Publikováno v: Journal of Biological Chemistry
Journal of Biological Chemistry, American Society for Biochemistry and Molecular Biology, 2020, pp.jbc.RA119.011817. ⟨10.1074/jbc.RA119.011817⟩
Journal of Biological Chemistry, 2020, pp.jbc.RA119.011817. ⟨10.1074/jbc.RA119.011817⟩
J Biol Chem

International audience; Despite the impressive progress made over the past 20 years in our understanding of mycolylarabinogalactan-peptidoglycan (mAGP) biogenesis, the mechanisms by which the tubercle bacillus Mycobacterium tuberculosis adapts its ce

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7361d37d2cf244f15dd89992dd74da90
https://researchportal.unamur.be/en/publications/96382eac-e4aa-4c2f-bf9c-198dca7ca6f5

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New cyrhetrenyl and ferrocenyl sulfonamides: Synthesis, characterization, X-ray crystallography, theoretical study and anti- Mycobacterium tuberculosis activity

Autor: Gisella Silva, Vania Artigas, Néstor Novoa, Rodrigo Arancibia, Cristóbal Quintana, A. Hugo Klahn, Mauricio Fuentealba, Iman Halloum, Christophe Biot, Laurent Kremer

Publikováno v: Polyhedron. 134:166-172

A new series of cyrhetrenyl and ferrocenyl sulfonamides were designed, synthesized and characterized. The reactions of organometallic amines (P2 and P3) with the corresponding arylsulfonyl chlorides produced cyrhetrenyl (2a-c) and ferrocenyl (3a-c) s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::dba0dea5c90309a064191af0259e7940
https://doi.org/10.1016/j.poly.2017.06.015

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Organometallic tosyl hydrazones: Synthesis, characterization, crystal structures and in vitro evaluation for anti- Mycobacterium tuberculosis and antiproliferative activities

Autor: Christophe Biot, Mauricio Fuentealba, A. Hugo Klahn, Yosselin Huentupil, Rodrigo López, Vania Artigas, Laurent Kremer, Iman Halloum, Rodrigo Arancibia, Javier Romanos, Camila Concha, Cristóbal Quintana

Publikováno v: Polyhedron
Artículos CONICYT
CONICYT Chile
instacron:CONICYT

A series of new organometallic tosyl hydrazones of the general formula [{(η5-C5H4)-C(R) = NNHSO2C6H4CH3}]M(CO)3 (M = Re, Mn; R = H, CH3) were prepared by the reaction between formyl or acetyl organometallic precursors with p-toluenesulfonyl hydrazid

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fd1f929b2e202a28bbf08f182760f002
https://doi.org/10.1016/j.poly.2017.04.031

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Identification of inhibitors targeting Mycobacterium tuberculosis cell wall biosynthesis via dynamic combinatorial chemistry

Autor: Jian Fu, Weidong Pan, Stéphane P. Vincent, Yufen Xia, Iman Halloum, Marc Dieu, Huixiao Fu, Laurent Kremer

Publikováno v: Chemical Communications. 53:10632-10635

In this study, we report a dynamic combinatorial approach alongwith highly efficient in situ screening to identify inhibitors of UDPgalactopyranosemutase (UGM), an essential enzyme involvedin mycobacterial cell wall biosynthesis. These two technologi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::58c0b3ad4014e048b50dcb583af1d46f
https://doi.org/10.1039/c7cc05251k

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A new dehydratase conferring innate resistance to thiacetazone and intra-amoebal survival ofMycobacterium smegmatis

Autor: Iman Halloum, Edouard Tuaillon, Séverine Carrère-Kremer, Yann Guérardel, Howard Takiff, Laeticia Alibaud, Jeroen Geurtsen, Laurent Kremer, Mickaël Blaise, Vipul K. Singh, Robert van de Weerd, Michel Drancourt

Publikováno v: Molecular Microbiology. 96:1085-1102

Nontuberculous mycobacteria are innately resistant to most antibiotics, although the mechanisms responsible for their drug resistance remain poorly understood. They are particularly refractory to thiacetazone (TAC), a second-line antitubercular drug.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::42a2b738c8524ddce281b4f7490d87b1
https://doi.org/10.1111/mmi.12992

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Antitumor activity of the synthetic retinoid ST1926 on primary effusion lymphoma in vitro and in vivo models

Autor: Nadine Darwiche, Louna Karam, Rana Abdel-Samad, Claudio Pisano, Frank Neipel, Iman Halloum, Bilal Houshaymi, Raghida Abou Merhi, Mariam Jaafar

Publikováno v: Oncology reports. 39(2)

Primary effusion lymphoma (PEL) is a rare B-cell neoplasm, associated with Kaposi sarcoma-associated herpes virus/human herpes virus-8 (KSHV/HHV-8), arising as malignant effusions in body cavities. PEL cells do not harbor conventional genetic cancer

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c812819c63e3628c9a778cb43f62e114
https://pubmed.ncbi.nlm.nih.gov/29207182

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Dry-Powder Inhaler Formulation of Rifampicin: An Improved Targeted Delivery System for Alveolar Tuberculosis

Autor: Iman Halloum, Laurent Kremer, Tejal Rawal, Shital Butani

Publikováno v: Journal of aerosol medicine and pulmonary drug delivery. 30(6)

Background: The delivery of antitubercular drugs through direct lung targeting can lead to reduction in the dose as well as side effects of the drug. In the present investigation, carrier (lactose)-based dry-powder inhaler of rifampicin was prepared

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e2791247afb2f024f6ba94db09e771a0
https://pubmed.ncbi.nlm.nih.gov/28510480

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