Dopaminergic denervation severity depends on COMT Val158Met polymorphism in Parkinson's disease

Autor: Jean-Baptiste Martini, Jean-Christophe Corvol, Julia Muellner, Florence Cormier-Dequaire, Marie-Odile Habert, Niklaus Meier, Andreas Hartmann, Aurélie Kas, Iman Gharrad, Alexis Brice, Marie Vidailhet, Khadija Tahiri, Alain Mallet, Michael Schuepbach

Publikováno v: Parkinsonism & Related Disorders
Parkinsonism & Related Disorders, 2015, 21 (5), pp.471-476. ⟨10.1016/j.parkreldis.2015.02.009⟩
Parkinsonism and Related Disorders
Parkinsonism and Related Disorders, Elsevier, 2015, 21 (5), pp.471-476. ⟨10.1016/j.parkreldis.2015.02.009⟩

International audience; Background : Catecholamine-O-methyl-tranferase (COMT) initiates dopamine degradation. Its activity is mainly determined by a single nucleotide polymorphism in the COMT gene (Val158Met, rs4680) separating high (Val/Val, COMTHH)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::18c090040ec176bbf0a780f0411bf0a8
https://pubmed.ncbi.nlm.nih.gov/25753458