Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Iman Farasat"'
Autor:
Xue W. Diefenbach, Iman Farasat, Erik D. Guetschow, Christopher J. Welch, Robert T. Kennedy, Shuwen Sun, Jeffrey C. Moore
Publikováno v:
ACS Omega, Vol 3, Iss 2, Pp 1498-1508 (2018)
Externí odkaz:
https://doaj.org/article/d35fa89dc6474fefa5e90d6466675aed
Autor:
Iman Farasat, Howard M Salis
Publikováno v:
PLoS Computational Biology, Vol 12, Iss 1, p e1004724 (2016)
The ability to precisely modify genomes and regulate specific genes will greatly accelerate several medical and engineering applications. The CRISPR/Cas9 (Type II) system binds and cuts DNA using guide RNAs, though the variables that control its on-t
Externí odkaz:
https://doaj.org/article/be10b3e391fd472db63a2cd6c09f7655
Autor:
Anna Fryszkowska, Chihui An, Oscar Alvizo, Goutami Banerjee, Keith A. Canada, Yang Cao, Duane DeMong, Paul N. Devine, Da Duan, David M. Elgart, Iman Farasat, Donald R. Gauthier, Erin N. Guidry, Xiujuan Jia, Jongrock Kong, Nikki Kruse, Katrina W. Lexa, Alexey A. Makarov, Benjamin F. Mann, Erika M. Milczek, Vesna Mitchell, Jovana Nazor, Claudia Neri, Robert K. Orr, Peter Orth, Eric M. Phillips, James N. Riggins, Wes A. Schafer, Steven M. Silverman, Christopher A. Strulson, Nandhitha Subramanian, Rama Voladri, Hao Yang, Jie Yang, Xiang Yi, Xiyun Zhang, Wendy Zhong
Publikováno v:
Science (New York, N.Y.). 376(6599)
The emergence of new therapeutic modalities requires complementary tools for their efficient syntheses. Availability of methodologies for site-selective modification of biomolecules remains a long-standing challenge, given the inherent complexity and
Autor:
Paul N. Devine, Ian Mangion, Benjamin F. Mann, Shuwen Sun, Erik D. Guetschow, Christopher J. Welch, Michael K. Wismer, Jeffrey C. Moore, Daniel A. Holland‐Moritz, Iman Farasat, Robert T. Kennedy
Publikováno v:
Angewandte Chemie International Edition. 59:4470-4477
Microfluidic droplet sorting enables the high-throughput screening and selection of water-in-oil microreactors at speeds and volumes unparalleled by traditional well-plate approaches. Most such systems sort using fluorescent reporters on modified sub
Autor:
John A. McIntosh, Zhijian Liu, Brian M. Andresen, Nastaran Salehi Marzijarani, Jeffrey C. Moore, Nicholas M. Marshall, Margie Borra-Garske, Jennifer V. Obligacion, Patrick S. Fier, Feng Peng, Jacob H. Forstater, Matthew S. Winston, Chihui An, Wonsuk Chang, Jongwon Lim, Mark A. Huffman, Steven P. Miller, Fuh-Rong Tsay, Michael D. Altman, Charles A. Lesburg, Dietrich Steinhuebel, B. Wesley Trotter, Jared N. Cumming, Alan Northrup, Xiaodong Bu, Benjamin F. Mann, Mirlinda Biba, Kaori Hiraga, Grant S. Murphy, Joshua N. Kolev, Amanda Makarewicz, Weilan Pan, Iman Farasat, Rachel S. Bade, Kevin Stone, Da Duan, Oscar Alvizo, Donovan Adpressa, Erik Guetschow, Erik Hoyt, Erik L. Regalado, Steve Castro, Nelo Rivera, Joseph P. Smith, Fengqiang Wang, Alejandro Crespo, Deeptak Verma, Stephanus Axnanda, Zachary E. X. Dance, Paul N. Devine, David Tschaen, Keith A. Canada, Paul G. Bulger, Benjamin D. Sherry, Matthew D. Truppo, Rebecca T. Ruck, Louis-Charles Campeau, David Jonathan Bennett, Guy R. Humphrey, Kevin R. Campos, Matthew L. Maddess
Publikováno v:
Nature. 603(7901)
The introduction of molecular complexity in an atom- and step-efficient manner remains an outstanding goal in modern synthetic chemistry. Artificial biosynthetic pathways are uniquely able to address this challenge by using enzymes to carry out multi
Autor:
Federica Orvieto, Mark J Demma, Canada Keith A, Alycia V Shoultz, Alessia Santoprete, Kuanchang Chen, Amy Bittner Mccracken, Xiaohong Zhu, Scott A. Johnson, Claudio Mapelli, Iman Farasat, Brian M. Lacey, Zachary Z Brown, Abbas Walji, Robert M. Garbaccio, Jennifer O'Neil, Elisabetta Bianchi
Publikováno v:
The Journal of organic chemistry. 85(3)
The Myc transcription factor represents an "undruggable" target of high biological interest due to its central role in various cancers. An abbreviated form of the c-Myc protein, called Omomyc, consists of the Myc DNA-binding domain and a coiled-coil
Autor:
Daniel P. Cetnar, Amin Espah Borujeni, Iman Farasat, Natasha Lundgren, Howard M. Salis, Ashlee Smith
Publikováno v:
Nucleic Acids Research
A mRNA’s translation rate is controlled by several sequence determinants, including the presence of RNA structures within the N-terminal regions of its coding sequences. However, the physical rules that govern when such mRNA structures will inhibit
Autor:
Shuwen Sun, Christopher J. Welch, Jeffrey C. Moore, Iman Farasat, Xue W. Diefenbach, Robert T. Kennedy, Erik D. Guetschow
Publikováno v:
ACS Omega
ACS Omega, Vol 3, Iss 2, Pp 1498-1508 (2018)
ACS Omega, Vol 3, Iss 2, Pp 1498-1508 (2018)
Directed Evolution is a key technology driving the utility of biocatalysis in pharmaceutical synthesis. Conventional approaches to Directed Evolution are conducted using bacterial cells expressing enzymes in microplates, with catalyzed reactions meas
Publikováno v:
Metabolic Engineering. 29:86-96
NADPH is an essential cofactor for the biosynthesis of several high-value chemicals, including isoprenoids, fatty acid-based fuels, and biopolymers. Tunable control over all potentially rate-limiting steps, including the NADPH regeneration rate, is c
Engineered heterologous metabolic pathways can convert low-cost feedstock into high-value products, though it remains a significant challenge to reliably and efficiently maximize end-product biosynthesis, particularly when many enzymes must be co-exp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8cef1f09323d9a6f8936ea9d81544048
https://doi.org/10.1101/161372
https://doi.org/10.1101/161372