Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Iman A. Moussa"'
Autor:
Ayat E. Abbas, Youmna Y. Zaghloul, Hany A. Omar, Iman G. Moussa, Fatima Hersi, Mohammad H. Semreen, Mohammed I. El-Gamal, Chang-Hyun Oh, Israa A. Younes
Publikováno v:
Bioorganic Chemistry. 97:103677
A series of cycloalkanecarboxamide-containing sulfonate and sulfamate derivatives were prepared, and their antiproliferative activity was tested against NCI-60 cancer cell lines panel. Compound 1f possessing cyclohexyl and p-(tert-butyl)benzenesulfon
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::edfb357bb44a6f892cf9e6352625a326
https://doi.org/10.1016/j.bioorg.2020.103677
https://doi.org/10.1016/j.bioorg.2020.103677
Autor:
Samuel D. Banister, Robert H. Mach, Jinquan Cui, Miral Manoli, Iman A. Moussa, Munikumar Reddy Doddareddy, Michael Kassiou
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 22:5493-5497
Imidazolidine and 1,4-diazepane analogs of N-(2-benzofuranyl)methyl-N′-(4-alkoxybenzyl)piperazines were prepared to explore the effect of ring contraction and expansion on σ receptor affinity and subtype selectivity within a series of cyclic diami
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ea3b3dd4cc14552ddee23ca265367956
https://doi.org/10.1016/j.bmcl.2012.07.026
https://doi.org/10.1016/j.bmcl.2012.07.026
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 21:6820-6823
N-(2-Benzofuranylmethyl)-N'-[4-(2-fluoroethoxy)benzyl]piperazine (6, σ(1)K(i)=2.6 nM) was radiolabeled with fluorine-18 to provide a potential σ(1) receptor radioligand for use in positron emission tomography (PET). Radiofluorination of the appropr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::398be3554baf7304fc17dbf639d674a6
https://doi.org/10.1016/j.bmcl.2011.09.028
https://doi.org/10.1016/j.bmcl.2011.09.028
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 21:5707-5710
In our continued exploration of disubstituted piperazine derivatives as sigma (σ) receptor ligands with central nervous system (CNS) activity, a series of N-(2-benzofuranylmethyl)-N'-(methoxyphenylalkyl)piperazines (16-21 and 26-31) were synthesized
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::87f400317d4a018269b830adce7777ce
https://doi.org/10.1016/j.bmcl.2011.08.029
https://doi.org/10.1016/j.bmcl.2011.08.029
Autor:
Aaron J. Reynolds, Iman A. Moussa, Samuel D. Banister, William T. Jorgensen, Corinne Beinat, Paolo Schiavini, Michael Kassiou
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 21:38-41
In our continued exploration of trishomocubane derivatives with central nervous system (CNS) activity, N -arylalkyl-8-aminopentacyclo[5.4.0.0 2,6 .0 3,10 .0 5,9 ]undecanes ( 10 – 13 ) displaying affinity for the sigma (σ) receptor were also found,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e7a0fc963a000caf2594380e17289b30
https://doi.org/10.1016/j.bmcl.2010.11.075
https://doi.org/10.1016/j.bmcl.2010.11.075
Autor:
Michael Kassiou, Corinne Beinat, Aaron J. Reynolds, Christopher S. P. McErlean, Samuel D. Banister, Iman A. Moussa
Publikováno v:
Current Medicinal Chemistry. 17:4166-4190
Excessive stimulation of NMDA receptors is involved in various CNS pathologies such as Parkinson's disease, acute and chronic pain and cerebral ischaemia. The use of NMDA antagonists as therapeutic agents has been restricted as a result of unwanted s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6eaf71da60eaea0fbd02a5c44868db70
https://doi.org/10.2174/092986710793348572
https://doi.org/10.2174/092986710793348572
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 20:145-148
Isomeric oxo-bridged analogs of aza-trishomocubane sigma (sigma) receptor ligands were synthesized and shown to display a reduced affinity for the sigma receptor. In the case of phenethyl derivative 4, there was a concomitant introduction of high-aff
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4897bd4e52d8f251209f0733fcc8fff8
https://doi.org/10.1016/j.bmcl.2009.11.019
https://doi.org/10.1016/j.bmcl.2009.11.019
Autor:
Iman A, Moussa, Samuel D, Banister, Miral, Manoli, Munikumar Reddy, Doddareddy, Jinquan, Cui, Robert H, Mach, Michael, Kassiou
Publikováno v:
Bioorganicmedicinal chemistry letters. 22(17)
Imidazolidine and 1,4-diazepane analogs of N-(2-benzofuranyl)methyl-N'-(4-alkoxybenzyl)piperazines were prepared to explore the effect of ring contraction and expansion on σ receptor affinity and subtype selectivity within a series of cyclic diamine
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::1f2e3b1e911d999ff1608019b0a280c2
https://pubmed.ncbi.nlm.nih.gov/22850210
https://pubmed.ncbi.nlm.nih.gov/22850210
Publikováno v:
Bioorganicmedicinal chemistry letters. 21(19)
In our continued exploration of disubstituted piperazine derivatives as sigma (σ) receptor ligands with central nervous system (CNS) activity, a series of N-(2-benzofuranylmethyl)-N'-(methoxyphenylalkyl)piperazines (16-21 and 26-31) were synthesized
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::85e8274717b26db81fbcb8b6abe989d7
https://pubmed.ncbi.nlm.nih.gov/21871797
https://pubmed.ncbi.nlm.nih.gov/21871797
Publikováno v:
Bioorganicmedicinal chemistry letters. 21(12)
A series of N-substituted 4-azahexacyclo[5.4.1.0(2,6).0(3,10).0(5,9).0(8,11)]dodecan-3-ols incorporating the respective arylalkyl subunits from several known sigma (σ) receptor ligands were synthesized and evaluated for their affinity against σ rec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0498519c958c4fe1ddc6ef4a4bf2430e
https://pubmed.ncbi.nlm.nih.gov/21555222
https://pubmed.ncbi.nlm.nih.gov/21555222