Inhibition of sphingolipid de novo synthesis counteracts muscular dystrophy

Autor: Laurila, Pirkka-Pekka, Luan, Peiling, Wohlwend, Martin, Zanou, Nadège, Crisol, Barbara, Imamura de Lima, Tanes, Goeminne, Ludger J. E., Gallart-Ayala, Hector, Shong, Minho, Ivanisevic, Julijana, Place, Nicolas, Auwerx, Johan

Publikováno v: Science advances, vol. 8, no. 4, pp. eabh4423
Science Advances

Duchenne muscular dystrophy (DMD), the most common muscular dystrophy, is a severe muscle disorder, causing muscle weakness, loss of independence, and premature death. Here, we establish the link between sphingolipids and muscular dystrophy. Transcri

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c6c980229bab1e5478c567e454e76cd5
https://serval.unil.ch/resource/serval:BIB_95F002D1A653.P001/REF.pdf

Urolithin A improves muscle function by inducing mitophagy in muscular dystrophy.

Autor: Luan, Peiling, D'Amico, Davide, Andreux, Pénélope A., Laurila, Pirkka-Pekka, Wohlwend, Martin, Li, Hao, Imamura de Lima, Tanes, Place, Nicolas, Rinsch, Chris, Zanou, Nadège, Auwerx, Johan

Publikováno v: Science Translational Medicine; 4/7/2021, Vol. 13 Issue 588, p1-12, 12p

Sphingolipids accumulate in aged muscle, and their reduction counteracts sarcopenia.

Autor: Laurila PP; Laboratory of Integrative Systems Physiology, École polytechnique fédérale de Lausanne (EPFL), Lausanne, Switzerland. pirkka-pekka.laurila@helsinki.fi., Wohlwend M; Laboratory of Integrative Systems Physiology, École polytechnique fédérale de Lausanne (EPFL), Lausanne, Switzerland., Imamura de Lima T; Laboratory of Integrative Systems Physiology, École polytechnique fédérale de Lausanne (EPFL), Lausanne, Switzerland., Luan P; Laboratory of Integrative Systems Physiology, École polytechnique fédérale de Lausanne (EPFL), Lausanne, Switzerland., Herzig S; Laboratory of Integrative Systems Physiology, École polytechnique fédérale de Lausanne (EPFL), Lausanne, Switzerland., Zanou N; Institute of Sport Sciences and Department of Biomedical Sciences, University of Lausanne, Lausanne, Switzerland., Crisol B; Laboratory of Integrative Systems Physiology, École polytechnique fédérale de Lausanne (EPFL), Lausanne, Switzerland., Bou-Sleiman M; Laboratory of Integrative Systems Physiology, École polytechnique fédérale de Lausanne (EPFL), Lausanne, Switzerland., Porcu E; Swiss Institute of Bioinformatics, Lausanne, Switzerland.; Center for Integrative Genomics, University of Lausanne, Lausanne, Switzerland., Gallart-Ayala H; Metabolomics Platform, Faculty of Biology and Medicine, University of Lausanne, Lausanne, Switzerland., Handzlik MK; Molecular and Cellular Biology Laboratory, The Salk Institute for Biological Studies, La Jolla, CA, USA., Wang Q; Laboratory of Integrative Systems Physiology, École polytechnique fédérale de Lausanne (EPFL), Lausanne, Switzerland., Jain S; Intonation Research Laboratories, Secunderabad, India., D'Amico D; Laboratory of Integrative Systems Physiology, École polytechnique fédérale de Lausanne (EPFL), Lausanne, Switzerland., Salonen M; Chronic Disease Prevention Unit, National Institute for Health and Welfare, Helsinki, Finland., Metallo CM; Molecular and Cellular Biology Laboratory, The Salk Institute for Biological Studies, La Jolla, CA, USA., Kutalik Z; Swiss Institute of Bioinformatics, Lausanne, Switzerland.; University Center for Primary Care and Public Health, University of Lausanne, Lausanne, Switzerland., Eichmann TO; Institute of Molecular Biosciences, University of Graz, Graz, Austria.; Center for Explorative Lipidomics, BioTechMed-Graz, Graz, Austria., Place N; Institute of Sport Sciences and Department of Biomedical Sciences, University of Lausanne, Lausanne, Switzerland., Ivanisevic J; Metabolomics Platform, Faculty of Biology and Medicine, University of Lausanne, Lausanne, Switzerland., Lahti J; Department of Psychology and Logopedics, University of Helsinki, Helsinki, Finland.; Turku Institute for Advanced Studies, University of Turku, Turku, Finland., Eriksson JG; Department of General Practice and Primary Health Care, University of Helsinki and Helsinki University Hospital, University of Helsinki, Helsinki, Finland.; Folkhälsan Research Center, University of Helsinki, Helsinki, Finland.; Department of Obstetrics and Gynecology, National University Singapore, Yong Loo Lin School of Medicine, Singapore, Singapore., Auwerx J; Laboratory of Integrative Systems Physiology, École polytechnique fédérale de Lausanne (EPFL), Lausanne, Switzerland. admin.auwerx@epfl.ch.

Publikováno v: Nature aging [Nat Aging] 2022 Dec; Vol. 2 (12), pp. 1159-1175. Date of Electronic Publication: 2022 Dec 16.

Acute RyR1 Ca ²⁺ leak enhances NADH-linked mitochondrial respiratory capacity.

Autor: Zanou N; Institute of Sport Sciences and Department of Biomedical Sciences, University of Lausanne, Lausanne, Switzerland. nad.zanou.mdphd@gmail.com., Dridi H; Department of Physiology and Cellular Biophysics, Clyde and Helen Wu Center for Molecular Cardiology, Columbia University Vagelos College of Physicians and Surgeons, New York, NY, USA., Reiken S; Department of Physiology and Cellular Biophysics, Clyde and Helen Wu Center for Molecular Cardiology, Columbia University Vagelos College of Physicians and Surgeons, New York, NY, USA., Imamura de Lima T; Laboratory of Integrative Systems Physiology (LISP), École Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland., Donnelly C; Institute of Sport Sciences and Department of Biomedical Sciences, University of Lausanne, Lausanne, Switzerland., De Marchi U; Nestlé Research - École Polytechnique Fédérale de Lausanne (EPFL), Innovation Park, Lausanne, Switzerland., Ferrini M; Institute of Sport Sciences and Department of Biomedical Sciences, University of Lausanne, Lausanne, Switzerland., Vidal J; Institute of Sport Sciences and Department of Biomedical Sciences, University of Lausanne, Lausanne, Switzerland., Sittenfeld L; Department of Physiology and Cellular Biophysics, Clyde and Helen Wu Center for Molecular Cardiology, Columbia University Vagelos College of Physicians and Surgeons, New York, NY, USA., Feige JN; Nestlé Research - École Polytechnique Fédérale de Lausanne (EPFL), Innovation Park, Lausanne, Switzerland.; School of Life Sciences, École Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland., Garcia-Roves PM; Department of Physiological Sciences, School of Medicine and Health Sciences, University of Barcelona and Bellvitge Biomedical Research Institute (IDIBELL), L'Hospitalet del Llobregat, Barcelona, Spain., Lopez-Mejia IC; Center for Integrative Genomics, University of Lausanne, Lausanne, Switzerland., Marks AR; Department of Physiology and Cellular Biophysics, Clyde and Helen Wu Center for Molecular Cardiology, Columbia University Vagelos College of Physicians and Surgeons, New York, NY, USA.; Department of Medicine, Division of Cardiology, Columbia University Medical Center, New York, NY, USA., Auwerx J; Laboratory of Integrative Systems Physiology (LISP), École Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland., Kayser B; Institute of Sport Sciences and Department of Biomedical Sciences, University of Lausanne, Lausanne, Switzerland., Place N; Institute of Sport Sciences and Department of Biomedical Sciences, University of Lausanne, Lausanne, Switzerland. nicolas.place@unil.ch.

Publikováno v: Nature communications [Nat Commun] 2021 Dec 10; Vol. 12 (1), pp. 7219. Date of Electronic Publication: 2021 Dec 10.