Zobrazeno 1 - 10
of 30
pro vyhledávání: '"Imam Hassouna"'
Autor:
Ayman A. Najjar, Imam Hassouna, Mahmoud A. Srour, Hany M. Ibrahim, Randa Y. Assi, Heba M. Abd El Latif
Publikováno v:
Thrombosis Journal, Vol 22, Iss 1, Pp 1-11 (2024)
Abstract Background Inherited thrombophilia (IT) has a complex pathophysiology and is associated with recurrent miscarriage (RM) by causing placental insufficiency and inhibiting fetal development. However, thrombophilia screening in unexplained RM c
Externí odkaz:
https://doaj.org/article/e3919e7756ed4722b8aeb84435ca6af9
Autor:
Ayman A. Najjar, Imam Hassouna, Mahmoud A. Srour, Hany M. Ibrahim, Randa Y. Assi, Heba M. Abd El Latif
Publikováno v:
BMC Pregnancy and Childbirth, Vol 23, Iss 1, Pp 1-11 (2023)
Abstract Background Multiple etiologies contribute to recurrent pregnancy loss (RPL) including immunological, endocrine, anatomical, genetic and infection but more than 50% of cases remain unexplained. Evidences of thrombotic and inflammatory process
Externí odkaz:
https://doaj.org/article/9c64b08ae6994133be5d4a1da61d311e
Autor:
Debia Wakhloo, Franziska Scharkowski, Yasmina Curto, Umer Javed Butt, Vikas Bansal, Agnes A. Steixner-Kumar, Liane Wüstefeld, Ashish Rajput, Sahab Arinrad, Matthias R. Zillmann, Anna Seelbach, Imam Hassouna, Katharina Schneider, Abdul Qadir Ibrahim, Hauke B. Werner, Henrik Martens, Kamilla Miskowiak, Sonja M. Wojcik, Stefan Bonn, Juan Nacher, Klaus-Armin Nave, Hannelore Ehrenreich
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
EPO treatment improves cognition, but underlying mechanisms were unknown. Here the authors describe a regulatory loop in which brain networks challenged by cognitive tasks drift into functional hypoxia that drives—via neuronal EPO synthesis—neuro
Externí odkaz:
https://doaj.org/article/9d32af3f067e4d66a0725b72c12bd117
Autor:
Imam Hassouna
Publikováno v:
Toxicology Reports, Vol 7, Iss , Pp 1608-1615 (2020)
The use of type II pyrethroids, cypermethrin is becoming a growing concern among environmental research centers. While most studies have attempted to cover the areas of DNA damage and microglia activation following exposure to cypermethin in the adul
Externí odkaz:
https://doaj.org/article/64a296702cb2480fa0d42d6cfe04b05b
Autor:
Laura Fernandez Garcia-Agudo, Agnes A. Steixner-Kumar, Yasmina Curto, Nadine Barnkothe, Imam Hassouna, Sebastian Jähne, Umer Javed Butt, Katharina Grewe, Martin S. Weber, Kim Green, Silvio Rizzoli, Juan Nacher, Klaus-Armin Nave, Hannelore Ehrenreich
Publikováno v:
Cell Reports, Vol 36, Iss 8, Pp 109548- (2021)
Summary: In adult cornu ammonis hippocampi, erythropoietin (EPO) expression drives the differentiation of new neurons, independent of DNA synthesis, and increases dendritic spine density. This substantial brain hardware upgrade is part of a regulator
Externí odkaz:
https://doaj.org/article/42f27ee525b44a1987ebb71c0214859d
Autor:
Umer Javed Butt, Imam Hassouna, Laura Fernandez Garcia-Agudo, Agnes A. Steixner-Kumar, Constanze Depp, Nadine Barnkothe, Matthias R. Zillmann, Anja Ronnenberg, Viktoria Bonet, Sandra Goebbels, Klaus-Armin Nave, Hannelore Ehrenreich
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 6, p 3164 (2021)
We previously introduced the brain erythropoietin (EPO) circle as a model to explain the adaptive ‘brain hardware upgrade’ and enhanced performance. In this fundamental circle, brain cells, challenged by motor-cognitive tasks, experience function
Externí odkaz:
https://doaj.org/article/4b9ec14957314d3b8d4633a066633bbe
Autor:
Anes Ju, Bekir Altas, Hong Jun Rhee, Manuela Schwark, Imam Hassouna, Albrecht Sigler, Hiroshi Kawabe, Kamal Chowdhury, Hannelore Ehrenreich, Nils Brose, JeongSeop Rhee
Heterozygous mutation ofAmbra1, known as a positive autophagy regulator, produces autismlike behavior in mice and autistic phenotypes in humans in a female-specific manner. However, the substantial roles of theAmbra1mutation in neurons are still unkn
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::17a39f8569cc28ea9588a712963d6037
https://doi.org/10.1101/2022.12.19.521004
https://doi.org/10.1101/2022.12.19.521004
Autor:
Tim Düking, Lena Spieth, Stefan A. Berghoff, Lars Piepkorn, Annika M. Schmidke, Miso Mitkovski, Nirmal Kannaiyan, Leon Hosang, Patricia Scholz, Ali H. Shaib, Lennart V. Schneider, Dörte Hesse, Torben Ruhwedel, Ting Sun, Lisa Linhoff, Andrea Trevisiol, Susanne Köhler, Adrian Marti Pastor, Thomas Misgeld, Michael Sereda, Imam Hassouna, Moritz J. Rossner, Francesca Odoardi, Till Ischebeck, Livia de Hoz, Johannes Hirrlinger, Olaf Jahn, Gesine Saher
Publikováno v:
Science Advances
Science advances 8(37), eabo7639 (2022). doi:10.1126/sciadv.abo7639
Science advances 8(37), eabo7639 (2022). doi:10.1126/sciadv.abo7639
To maintain homeostasis, the body, including the brain, reprograms its metabolism in response to altered nutrition or disease. However, the consequences of these challenges for the energy metabolism of the different brain cell types remain unknown. H
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::429b042988b73b13bc8c23baed1b8d83
https://hdl.handle.net/21.11116/0000-000B-3BC4-621.11116/0000-000B-3BC6-4
https://hdl.handle.net/21.11116/0000-000B-3BC4-621.11116/0000-000B-3BC6-4
Autor:
Laura Fernandez Garcia-Agudo, Umer Javed Butt, Imam Hassouna, Matthias R. Zillmann, Anja Ronnenberg, Constanze Depp, Hannelore Ehrenreich, Viktoria Bonet, Klaus-Armin Nave, Nadine Barnkothe, Sandra Goebbels, Agnes A. Steixner-Kumar
Publikováno v:
International Journal of Molecular Sciences
Volume 22
Issue 6
International Journal of Molecular Sciences, Vol 22, Iss 3164, p 3164 (2021)
International journal of molecular sciences.
Volume 22
Issue 6
International Journal of Molecular Sciences, Vol 22, Iss 3164, p 3164 (2021)
International journal of molecular sciences.
We previously introduced the brain erythropoietin (EPO) circle as a model to explain the adaptive ‘brain hardware upgrade’ and enhanced performance. In this fundamental circle, brain cells, challenged by motor-cognitive tasks, experience function
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::40c7f498453ef49aebe8f97d77af4259
https://hdl.handle.net/21.11116/0000-000C-81F0-221.11116/0000-000C-81F2-0
https://hdl.handle.net/21.11116/0000-000C-81F0-221.11116/0000-000C-81F2-0
Genetically induced brain inflammation by Cnp deletion transiently benefits from microglia depletion
Autor:
Imam Hassouna, Felicia J. van der Flier, Martin S. Weber, Nadine Schopf, Sahab Arinrad, Laura Fernandez Garcia-Agudo, Hana Janova, Hannelore Ehrenreich, Anja Ronnenberg, Susann Boretius, Henrik Martens, Klaus-Armin Nave, Evan Balmuth, Lea E. Sendler, Martin Begemann, Agnes Steixner
Publikováno v:
The FASEB Journal. 33:8634-8647
Reduced expression of 2'-3′-cyclic nucleotide 3′-phosphodiesterase (Cnp) in humans and mice causes white matter inflammation and catatonic signs. These consequences are experimentally alleviated by...