Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Imala Alwis"'
Autor:
Lining Ju, James D. McFadyen, Saheb Al-Daher, Imala Alwis, Yunfeng Chen, Lotte L. Tønnesen, Sophie Maiocchi, Brianna Coulter, Anna C. Calkin, Eric I. Felner, Neale Cohen, Yuping Yuan, Simone M. Schoenwaelder, Mark E. Cooper, Cheng Zhu, Shaun P. Jackson
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-16 (2018)
Diabetes is associated with an increased thrombotic response, but the mechanism is unknown. Here the authors demonstrate that compressive force activates integrin αIIbβ3 on discoid diabetic platelets and that platelet aggregates can be eliminated b
Externí odkaz:
https://doaj.org/article/39fb3cca5ca9489ba78bd4ef5db73aba
Autor:
Emma E. Watson, Xuyu Liu, Robert E. Thompson, Jorge Ripoll-Rozada, Mike Wu, Imala Alwis, Alessandro Gori, Choy-Theng Loh, Benjamin L. Parker, Gottfried Otting, Shaun Jackson, Pedro José Barbosa Pereira, Richard J. Payne
Publikováno v:
ACS Central Science, Vol 4, Iss 4, Pp 468-476 (2018)
Externí odkaz:
https://doaj.org/article/39f6c6008a294a2faf94d657f88622d6
Publikováno v:
Blood Advances. 7:982-986
Autor:
Mike C. L. Wu, Imala Alwis, Richard J. Payne, Pedro Pereira, Shaun P. Jackson, Emma E. Watson, Jorge Ripoll-Rozada, Stijn M. Agten, Luke J. Dowman
Publikováno v:
Angewandte Chemie-International Edition, 60(10), 5348-5356. Wiley-VCH Verlag
Blood feeding arthropods, such as leeches, ticks, flies and mosquitoes, provide a privileged source of peptidic anticoagulant molecules. These primarily operate through inhibition of the central coagulation protease thrombin by binding to the active
Autor:
Stijn M. Agten, Emma E. Watson, Jorge Ripoll‐Rozada, Luke J. Dowman, Mike C. L. Wu, Imala Alwis, Shaun P. Jackson, Pedro José Barbosa Pereira, Richard J. Payne
Publikováno v:
Angewandte Chemie. 133:5408-5416
Autor:
Lining Arnold Ju, Sabine Kossmann, Yunduo Charles Zhao, Laura Moldovan, Yingqi Zhang, Savindi De Zoysa Ramasundara, Fangyuan Zhou, Hang Lu, Imala Alwis, Simone M. Schoenwaelder, Yuping Yuan, Shaun P. Jackson
Publikováno v:
The Analyst. 147(6)
Microvascular thrombosis and inflammation (thromboinflammation) are major causes of morbidity and mortality in critically ill patients with limited therapeutic options. Platelets are central to thromboinflammation, and microvascular platelet thrombi
Autor:
Chloe-Anne Martinez, Yannasittha Jiramongkol, Neha Bal, Imala Alwis, Polina E. Nedoboy, Melissa M.J. Farnham, Mark D. White, Peter A. Cistulli, Kristina M. Cook
Publikováno v:
The Journal of biological chemistry. 298(11)
The cellular response to hypoxia is regulated through enzymatic oxygen sensors, including the prolyl hydroxylases, which control degradation of the well-known hypoxia inducible factors (HIFs). Other enzymatic oxygen sensors have been recently identif
Autor:
Jessica A. A. Maclean, Amelia J. Tomkins, Sharelle A. Sturgeon, Benjamin R. Hofma, Imala Alwis, Andre L. Samson, Simone M. Schoenwaelder, Shaun P. Jackson
Publikováno v:
Blood advances. 6(18)
Recanalization with restored cerebral perfusion is the primary goal of thrombolytic therapy in acute ischemic stroke. The identification of adjunctive therapies that can be safely used to enhance thrombolysis in stroke remains an elusive goal. We rep
Autor:
Imala Alwis, Jorge Ripoll-Rozada, Pedro Pereira, Choy-Theng Loh, Mike Wu, Robert E. Thompson, Gottfried Otting, Shaun P. Jackson, Emma E. Watson, Xuyu Liu, Richard J. Payne, Benjamin L. Parker, Alessandro Gori
Publikováno v:
Repositório Científico de Acesso Aberto de Portugal
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAP
ACS Central Science, Vol 4, Iss 4, Pp 468-476 (2018)
ACS Central Science
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAP
ACS Central Science, Vol 4, Iss 4, Pp 468-476 (2018)
ACS Central Science
The anophelins are small protein thrombin inhibitors that are produced in the salivary glands of the Anopheles mosquito to fulfill a vital role in blood feeding. A bioinformatic analysis of anophelin sequences revealed the presence of conserved tyros
Autor:
Brianna Coulter, Yunfeng Chen, Saheb Al-Daher, Lining Ju, Eric I. Felner, Shaun P. Jackson, Mark E. Cooper, Lotte Lindhardt Tonnesen, Yuping Yuan, Neale Cohen, Cheng Zhu, James D. McFadyen, Sophie Maiocchi, Anna C. Calkin, Simone M. Schoenwaelder, Imala Alwis
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-16 (2018)
Nature Communications
Nature Communications
Diabetes is associated with an exaggerated platelet thrombotic response at sites of vascular injury. Biomechanical forces regulate platelet activation, although the impact of diabetes on this process remains ill-defined. Using a biomembrane force pro