Zobrazeno 1 - 4
of 4
pro vyhledávání: '"Imad Nashashibi"'
Design, synthesis and SAR of a novel series of heterocyclic phenylpropanoic acids as GPR120 agonists
Autor:
Austin Bell, Hong Hua, Wen Yan, Chaozhong Cai, Celia Jenkinson, Peter Haug, Wall Mark, Yuanping Wang, Imad Nashashibi, Xuqing Zhang, Arthur T. Suckow, Michael P. Winters, James N. Leonard, Michele Wells, Joseph Gunnet, William V. Murray, Zhihua Sui, Jingyuan Ma, James C. Lanter, Wilma Clapper, Aaron Novack
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 27:3272-3278
A novel series of 5-membered heterocycle-containing phenylpropanoic acid derivatives was discovered as potent GPR120 agonists with low clearance, high oral bioavailability and in vivo antidiabetic activity in rodents.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c99a9954f694ac0a6035dcb18ac83bf
https://doi.org/10.1016/j.bmcl.2017.06.028
https://doi.org/10.1016/j.bmcl.2017.06.028
Autor:
Xuefei Tan, Joon Jung, Albert Liclican, Daniel E. Levy, Kurt Schinzel, Imad Nashashibi, Gregory R. Luedtke, Weiling Liang, Sundeep Dugar, Steven Do, Jocelyn Tabora, Richland Tester
Publikováno v:
Bioorganicmedicinal chemistry letters. 20(8)
Optimization of a tri-substituted N-pyridyl amide led to the discovery of a new class of potent N-pyrimidyl amide based p38alpha MAP kinase inhibitors. Initial SAR studies led to the identification of 5-dihydrofuran as an optimal hydrophobic group. A
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::968237a0bdda3e69c0aa71268f383958
https://pubmed.ncbi.nlm.nih.gov/20346659
https://pubmed.ncbi.nlm.nih.gov/20346659
Autor:
Joon Jung, Gregory R. Luedtke, Sundeep Dugar, Yong-jin Xu, Daniel E. Levy, Xuefei Tan, Imad Nashashibi, Kurt Schinzel, Richland Tester
Publikováno v:
Bioorganicmedicinal chemistry letters. 20(8)
A novel series of N-pyridyl amides as potent p38alpha kinase inhibitors is described. Based on the structural similarities between the initial hit and a well-known imidazole pyrimidine series of p38alpha inhibitors, potencies within the newly discove
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::68cc3da6000cad5d235066118c776382
https://pubmed.ncbi.nlm.nih.gov/20346653
https://pubmed.ncbi.nlm.nih.gov/20346653
Autor:
Jie Hu, John J. Perumattam, Joon Jung, Sundeep Dugar, Jocelyn Tabora, Sarvajit Chakravarty, Imad Nashashibi, Qing Lu, Albert Liclican, Daniel E. Levy, Maureen Laney, Xuefei Tan, Gregory R. Luedtke, Ramona Almirez, Richland Tester, Vinh Tran, Babu J. Mavunkel
Publikováno v:
Bioorganicmedicinal chemistry letters. 20(3)
Derivatives of the 4-fluorobenzyl dimethylpiperazine-indole class of p38alpha MAP kinase inhibitors are described. Biological evaluation of these compounds focused on maintaining activity while improving pharmacokinetic (PK) properties. Improved prop
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ab090924b003a47ad9f1dc0b58b36e5e
https://pubmed.ncbi.nlm.nih.gov/20071169
https://pubmed.ncbi.nlm.nih.gov/20071169