Zobrazeno 1 - 10
of 412
pro vyhledávání: '"Im‑Sook Song"'
Autor:
Ji-Hyeon Jeon, So-Yeon Jeon, Yeon-Ju Baek, Chan-E Park, Min-Koo Choi, Young Taek Han, Im-Sook Song
Publikováno v:
Pharmaceutics, Vol 16, Iss 7, p 934 (2024)
The quinoline alkaloid 2-(quinoline-8-carboxamido)benzoic acid (2-QBA), which is isolated from Aspergillus sp. SCSIO06786, a deep sea-derived fungus, has been suggested as a therapeutic candidate for the treatment of Parkinson’s disease. We develop
Externí odkaz:
https://doaj.org/article/6a34bbe9da6948b8bdbc83f8a76f1479
Autor:
Min Seo Lee, Jihoon Lee, Minyoung Pang, John Kim, Hyunju Cha, Banyoon Cheon, Min-Koo Choi, Im-Sook Song, Hye Suk Lee
Publikováno v:
Pharmaceutics, Vol 16, Iss 6, p 799 (2024)
Zastaprazan (JP-1366), a novel potassium-competitive acid blocker, is a new drug for the treatment of erosive esophagitis. JP-1366 is highly metabolized in human, mouse, and dog hepatocytes but moderately metabolized in rat and monkey hepatocytes whe
Externí odkaz:
https://doaj.org/article/d22f1234d718446cb00384ce6e9851c9
Autor:
Byung Jo Choi, Min Hee Park, Kang Ho Park, Wan Hui Han, Hee Ji Yoon, Hye Yoon Jung, Ju Yeon Hong, Md Riad Chowdhury, Kyung Yeol Kim, Jihoon Lee, Im-Sook Song, Minyeong Pang, Min-Koo Choi, Erich Gulbins, Martin Reichel, Johannes Kornhuber, Chang-Won Hong, Changho Kim, Seung Hyun Kim, Edward H. Schuchman, Hee Kyung Jin, Jae-sung Bae
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-17 (2023)
Acid sphingomyelinase (ASM) is a sphingolipid metabolizing enzyme that catalyzes the hydrolysis of sphingomyelin to ceramide, and previous work has shown it is upregulated in models of Alzheimer’s disease. Here the authors demonstrate in a mouse mo
Externí odkaz:
https://doaj.org/article/52c99cf51ae64f39b52ec19ee7f53cf4
Publikováno v:
Pharmaceutical Biology, Vol 60, Iss 1, Pp 2266-2275 (2022)
Context Zeaxanthin is a yellow‑coloured dietary carotenoid widely recognized as an essential component of the macula. It exerts blue light filtering and antioxidant activities, offering eye health and vision benefits.Objective This study explores t
Externí odkaz:
https://doaj.org/article/783f723bfea246688224670c5ab18bdb
Autor:
Ki-Young Kim, Yeo-Jin Jeong, So-Young Park, Eun-Ji Park, Ji-Hyeon Jeon, Im-Sook Song, Kwang-Hyeon Liu
Publikováno v:
Pharmaceutics, Vol 16, Iss 1, p 106 (2024)
A liver injury was recently reported for saxagliptin, which is a dipeptidyl peptidase-4 (DPP-4) inhibitor. However, the underlying mechanisms of saxagliptin-induced liver injury remain unknown. This study aimed to evaluate whether saxagliptin, a pote
Externí odkaz:
https://doaj.org/article/136feddb6cc34621af2d217e2c85287c
Autor:
Jun-Kyu Byun, Seunghyeong Lee, Gil Won Kang, Yu Rim Lee, Soo Young Park, Im-Sook Song, Jae Won Yun, Jaebon Lee, Yeon-Kyung Choi, Keun-Gyu Park
Publikováno v:
Journal of Experimental & Clinical Cancer Research, Vol 41, Iss 1, Pp 1-16 (2022)
Abstract Background Macropinocytosis, an important nutrient-scavenging pathway in certain cancer cells, allows cells to compensate for intracellular amino acid deficiency under nutrient-poor conditions. Ferroptosis caused by cysteine depletion plays
Externí odkaz:
https://doaj.org/article/62fdcafd44e94a9aaab7d63938468126
Publikováno v:
Pharmaceuticals, Vol 16, Iss 6, p 802 (2023)
Doxorubicin (DOX), a widely used drug in cancer chemotherapy, induces cell death via multiple intracellular interactions, generating reactive oxygen species and DNA-adducted configurations that induce apoptosis, topoisomerase II inhibition, and histo
Externí odkaz:
https://doaj.org/article/8ca1fc05de3d4d158421e7da2ee4d3f0
Autor:
Young Sun Choi, Hyeonha Jang, Biki Gupta, Ji-Hak Jeong, Yun Ge, Chul Soon Yong, Jong Oh Kim, Jong-Sup Bae, Im-Sook Song, In-San Kim, You Mie Lee
Publikováno v:
Journal of Hematology & Oncology, Vol 13, Iss 1, Pp 1-18 (2020)
Abstract Background Conventional therapeutic approaches for tumor angiogenesis, which are primarily focused on the inhibition of active angiogenesis to starve cancerous cells, target the vascular endothelial growth factor signaling pathway. This aggr
Externí odkaz:
https://doaj.org/article/db80f33a15cc4fada2f1b9246ca794b9
Autor:
Ju Youn Lee, Seung Hoon Han, Min Hee Park, Im-Sook Song, Min-Koo Choi, Eunsoo Yu, Cheol-Min Park, Hee-Jin Kim, Seung Hyun Kim, Edward H. Schuchman, Hee Kyung Jin, Jae-sung Bae
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-19 (2020)
Neuronal sphingosine kinase 1 (SphK1) acetylates COX2 which is needed for microglial phagocytosis activity, and release of pro-resolving mediators (SPMs) from neurons. Here the authors examine how SphK1-mediates COX2 acetylation, and how this leads t
Externí odkaz:
https://doaj.org/article/3035df8592594ac98f3be370c56a59d8
Autor:
Min-Koo Choi, Sojeong Jin, Ji-Hyeon Jeon, Woo Youl Kang, Sook Jin Seong, Young-Ran Yoon, Yong-Hae Han, Im-Sook Song
Publikováno v:
Journal of Ginseng Research, Vol 44, Iss 2, Pp 229-237 (2020)
Background: We investigated the tolerability and pharmacokinetic properties of various ginsenosides, including Rb1, Rb2, Rc, Rd, and compound K, after single or multiple administrations of red ginseng extract in human beings. Methods: Red ginseng ext
Externí odkaz:
https://doaj.org/article/979ee5ff98454807938bc493ceac3044