The Long Noncoding RNA DNM3OS Is a Reservoir of FibromiRs with Major Functions in Lung Fibroblast Response to TGF-β and Pulmonary Fibrosis

Autor: Nihal Martis, Virginie Magnone, Franck Broly, Bruno Crestani, Pascal Barbry, Nicolas Nottet, Elisabeth Courcot, Nicolas Pottier, Imène-Sarah Henaoui, Grégoire Savary, Nicolas Pons, Roger Rezzonico, Benoit Wallaert, Bernard Mari, Kevin Lebrigand, Agnès Paquet, Matthieu Buscot, Véronique Hofman, Michael Perrais, François Glowacki, Julien Fassy, Cynthia Van der Hauwaert, Paul Hofman, Charles-Hugo Marquette, Sylvie Leroy, Edmone Dewaeles, Georges Vassaux, Christian L. Lino Cardenas, Andreas Günther, Christelle Cauffiez, Saverio Bellusci, Serena Diazzi, Julie Lemaire, Thierry Brousseau, Laurent Plantier

Publikováno v: American Journal of Respiratory and Critical Care Medicine
American Journal of Respiratory and Critical Care Medicine, American Thoracic Society, 2019, 200 (2), pp.184-198. ⟨10.1164/rccm.201807-1237OC⟩
American Journal of Respiratory and Critical Care Medicine, 2019, 200 (2), pp.184-198. ⟨10.1164/rccm.201807-1237OC⟩

Rationale: Given the paucity of effective treatments for idiopathic pulmonary fibrosis (IPF), new insights into the deleterious mechanisms controlling lung fibroblast activation, the key cell type driving the fibrogenic process, are essential to deve

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e424679e109516d44a94df00182b5745
https://hal.archives-ouvertes.fr/hal-02413473

Therapeutic potential of miRNAs in diabetes mellitus

Autor: Ksenia Tugay, Imène Sarah Henaoui, Lisa Stoll, Romano Regazzi

Publikováno v: Expert review of endocrinologymetabolism. 10(3)

miRNAs are major regulators of gene expression that are emerging as central players in the development of many human diseases, including diabetes mellitus. In fact, the manifestation of diabetes is associated with alterations in the miRNA profile in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::902f0634969fafb0b71acdbb251a7e53
https://pubmed.ncbi.nlm.nih.gov/30298776

PIWI-interacting RNAs as novel regulators of pancreatic beta cell function

Autor: Lena Eliasson, Inês G. Mollet, Jonathan Sobel, Romano Regazzi, Imène Sarah Henaoui, Claudiane Guay, Cécile Jacovetti

Publikováno v: Diabetologia, vol. 60, no. 10, pp. 1977-1986

P-element induced Wimpy testis (PIWI)-interacting RNAs (piRNAs) are small non-coding RNAs that interact with PIWI proteins and guide them to silence transposable elements. They are abundantly expressed in germline cells and play key roles in spermato

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1582a42cbce3a650a289102435ae0c32
https://serval.unil.ch/notice/serval:BIB_5F3CDB100E39

SENS-IS, a 3D reconstituted epidermis based model for quantifying chemical sensitization potency: Reproducibility and predictivity results from an inter-laboratory study

Autor: Imène-Sarah Henaoui, Claude Auriault, Pascal Barbry, Jean-Claude Ourlin, Elodie Boitel, Pierre Aeby, Hervé Groux, Jean-Luc Peiffer, Bernard Mari, Isabelle Fabre, Agnès Paquet, Françoise Cottrez, Ambre Vallauri

Publikováno v: Toxicology in vitro : an international journal published in association with BIBRA. 32

The SENS-IS test protocol for the in vitro detection of sensitizers is based on a reconstructed human skin model (Episkin) as the test system and on the analysis of the expression of a large panel of genes. Its excellent performance was initially dem

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c1dc9463071decf636ae1cd34f90b6cf
https://pubmed.ncbi.nlm.nih.gov/26795242

miR-199a-5p Is upregulated during fibrogenic response to tissue injury and mediates TGFbeta-induced lung fibroblast activation by targeting caveolin-1

Autor: Pascal Barbry, Julien Maurizio, François Glowacki, Benoit Wallaert, Christoph Roderburg, Marie-Christine Copin, Christian L. Lino Cardenas, Michael Perrais, John Tedrow, Sébastien Aubert, Tom Luedde, Brice Marcet, Jadranka Milosevic, Nicolas Pottier, Edmone Dewaeles, Bernard Mari, Jean-Marc Lo-Guidice, Imène Sarah Henaoui, Naftali Kaminski, Elisabeth Courcot, Christelle Cauffiez

Publikováno v: PLoS Genetics, Vol 9, Iss 2, p e1003291 (2013)
PLoS Genetics
PLoS genetics 9(2), e1003291 (2013). doi:10.1371/journal.pgen.1003291
PLoS Genetics; Vol 9

As miRNAs are associated with normal cellular processes, deregulation of miRNAs is thought to play a causative role in many complex diseases. Nevertheless, the precise contribution of miRNAs in fibrotic lung diseases, especially the idiopathic form (

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bbdfa56610ab82b075eabb1aa2641b28
http://europepmc.org/articles/PMC3573122?pdf=render