Zobrazeno 1 - 10
of 31
pro vyhledávání: '"Ilze Elbere"'
Autor:
Emily Van Syoc, Michelle Pistner Nixon, Justin D. Silverman, Yuhong Luo, Frank J. Gonzalez, Ilze Elbere, Janis Klovins, Andrew D. Patterson, Connie J. Rogers, Erika Ganda
Publikováno v:
mBio, Vol 15, Iss 6 (2024)
ABSTRACT The human gut teems with a diverse ecosystem of microbes, yet non-bacterial portions of that community are overlooked in studies of metabolic diseases firmly linked to gut bacteria. Type 2 diabetes mellitus (T2D) is associated with compositi
Externí odkaz:
https://doaj.org/article/26fca0c5e5f544fb8c1919e9590c4c31
Autor:
Monta Brīvība, Laila Silamiķele, Ineta Kalniņa, Ivars Silamiķelis, Līga Birzniece, Laura Ansone, Lauma Jagare, Ilze Elbere, Jānis Kloviņš
Publikováno v:
Frontiers in Endocrinology, Vol 14 (2023)
IntroductionResearch findings of the past decade have highlighted the gut as the main site of action of the oral antihyperglycemic agent metformin despite its pharmacological role in the liver. Extensive evidence supports metformin’s modulatory eff
Externí odkaz:
https://doaj.org/article/6beaf56def1b40759d3844d059c0a2ee
Autor:
Monta Brīvība, Laila Silamiķele, Līga Birzniece, Laura Ansone, Kaspars Megnis, Ivars Silamiķelis, Līva Pelcmane, Daniella Borisova, Maija Rozenberga, Lauma Jagare, Ilze Elbere, Jānis Kloviņš
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 1, p 567 (2024)
The gut microbiome plays a pivotal role in the modulation of host responses during viral infections, and recent studies have underscored its significance in the context of coronavirus disease 2019 (COVID-19). We aimed to investigate the dynamics and
Externí odkaz:
https://doaj.org/article/d4ba938c0bea4b7aa13950221fb8dd53
Autor:
Monta Brīvība, Ivanna Atava, Raitis Pečulis, Ilze Elbere, Laura Ansone, Maija Rozenberga, Ivars Silamiķelis, Jānis Kloviņš
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 2, p 1151 (2024)
Numerous type 2 diabetes (T2D) polygenic risk scores (PGSs) have been developed to predict individuals’ predisposition to the disease. An independent assessment and verification of the best-performing PGS are warranted to allow for a rapid applicat
Externí odkaz:
https://doaj.org/article/be1bf08149234e0bb2b6a51c4331d1fb
Autor:
Zane Straume, Nikola Krūmiņa, Ilze Elbere, Maija Rozenberga, Dace Rudzīte, Anna Proskurina, Juliana Ozoliņa, Jānis Kloviņš, Vita Skuja, Angelika Krūmiņa
Publikováno v:
Medicina, Vol 60, Iss 1, p 182 (2024)
Background and Objectives: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2 is the new coronavirus that caused the coronavirus disease 2019 (COVID-19) outbreak. Studies have increasingly reported the involvement of organs outside the respi
Externí odkaz:
https://doaj.org/article/d547e01c10a44e3ca3adbfa549b17e6f
Autor:
Ilze Elbere, Zigmunds Orlovskis, Laura Ansone, Ivars Silamikelis, Lauma Jagare, Liga Birzniece, Kaspars Megnis, Kristaps Leskovskis, Annija Vaska, Maris Turks, Kristaps Klavins, Valdis Pirags, Monta Briviba, Janis Klovins
Publikováno v:
Gut Microbes, Vol 16, Iss 1 (2024)
Metformin is widely used for treating type 2 diabetes mellitus (T2D). However, the efficacy of metformin monotherapy is highly variable within the human population. Understanding the potential indirect or synergistic effects of metformin on gut micro
Externí odkaz:
https://doaj.org/article/69e2187b22ff47c3be1527681e9d49fe
Autor:
Monta Ustinova, Raitis Peculis, Raimonds Rescenko, Vita Rovite, Linda Zaharenko, Ilze Elbere, Laila Silamikele, Ilze Konrade, Jelizaveta Sokolovska, Valdis Pirags, Janis Klovins
Publikováno v:
BMC Medical Genomics, Vol 14, Iss 1, Pp 1-11 (2021)
Abstract Background Type 2 diabetes complications cause a serious emotional and economical burden to patients and healthcare systems globally. Management of both acute and chronic complications of diabetes, which dramatically impair the quality of pa
Externí odkaz:
https://doaj.org/article/eff6c95da64843748bc416c62dc2702e
Autor:
Laila Silamiķele, Ivars Silamiķelis, Monta Ustinova, Zane Kalniņa, Ilze Elbere, Ramona Petrovska, Ineta Kalniņa, Jānis Kloviņš
Publikováno v:
Frontiers in Endocrinology, Vol 12 (2021)
Effects of metformin, the first-line drug for type 2 diabetes therapy, on gut microbiome composition in type 2 diabetes have been described in various studies both in human subjects and animals. However, the details of the molecular mechanisms of met
Externí odkaz:
https://doaj.org/article/fa70e258c0524c028c9f7a617c75e902
Autor:
Ilze Elbere, Ivars Silamikelis, Monta Ustinova, Ineta Kalnina, Linda Zaharenko, Raitis Peculis, Ilze Konrade, Diana Maria Ciuculete, Christina Zhukovsky, Dita Gudra, Ilze Radovica-Spalvina, Davids Fridmanis, Valdis Pirags, Helgi B. Schiöth, Janis Klovins
Publikováno v:
Clinical Epigenetics, Vol 10, Iss 1, Pp 1-13 (2018)
Abstract Background Metformin is a widely prescribed antihyperglycemic agent that has been also associated with multiple therapeutic effects in various diseases, including several types of malignancies. There is growing evidence regarding the contrib
Externí odkaz:
https://doaj.org/article/1dae33c968ed4993b33f70dbe50c084b
Autor:
Isabel Moreno-Indias, Leo Lahti, Miroslava Nedyalkova, Ilze Elbere, Gennady Roshchupkin, Muhamed Adilovic, Onder Aydemir, Burcu Bakir-Gungor, Enrique Carrillo-de Santa Pau, Domenica D’Elia, Mahesh S. Desai, Laurent Falquet, Aycan Gundogdu, Karel Hron, Thomas Klammsteiner, Marta B. Lopes, Laura Judith Marcos-Zambrano, Cláudia Marques, Michael Mason, Patrick May, Lejla Pašić, Gianvito Pio, Sándor Pongor, Vasilis J. Promponas, Piotr Przymus, Julio Saez-Rodriguez, Alexia Sampri, Rajesh Shigdel, Blaz Stres, Ramona Suharoschi, Jaak Truu, Ciprian-Octavian Truică, Baiba Vilne, Dimitrios Vlachakis, Ercument Yilmaz, Georg Zeller, Aldert L. Zomer, David Gómez-Cabrero, Marcus J. Claesson
Publikováno v:
Frontiers in Microbiology, Vol 12 (2021)
The human microbiome has emerged as a central research topic in human biology and biomedicine. Current microbiome studies generate high-throughput omics data across different body sites, populations, and life stages. Many of the challenges in microbi
Externí odkaz:
https://doaj.org/article/58ddf268165e41df95208c7ec045cc9d