Zobrazeno 1 - 10
of 185
pro vyhledávání: '"Ilze Bot"'
Autor:
Virginia Smit, Jill de Mol, Mireia N. A. Bernabé Kleijn, Marie A. C. Depuydt, Menno P. J. de Winther, Ilze Bot, Johan Kuiper, Amanda C. Foks
Publikováno v:
Immunity & Ageing, Vol 21, Iss 1, Pp 1-15 (2024)
Abstract Background Atherosclerosis, the main underlying pathology of cardiovascular disease, is a chronic inflammatory disease characterized by lipid accumulation and immune cell responses in the vascular wall, resulting in plaque formation. It is w
Externí odkaz:
https://doaj.org/article/b14e5b874ade4e8180fc0cb6e3004836
Autor:
Anjana Singh, Adriaan O. Kraaijeveld, Adelina Curaj, Kanin Wichapong, Linda Hammerich, Saskia C. A. de Jager, Ilze Bot, Sergei P. Atamas, Theo J. C. van Berkel, J. Wouter Jukema, Iain Comerford, Shaun R. McColl, Barend Mees, Johan W. M. Heemskerk, Gerry A. F. Nicolaes, Tilman Hackeng, Elisa Anamaria Liehn, Frank Tacke, Erik A. L. Biessen
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
IntroductionThe CC chemokine ligand 18 (CCL18) is a chemokine highly expressed in chronic inflammation in humans. Recent observations of elevated CCL18 plasma levels in patients with acute cardiovascular syndromes prompted an investigation into the r
Externí odkaz:
https://doaj.org/article/573017efcc53412a84624e171b71058e
Autor:
Wietse In Het Panhuis, Milena Schönke, Melanie Modder, Hannah E. Tom, Reshma A. Lalai, Amanda C.M. Pronk, Trea C.M. Streefland, Linda W.M. van Kerkhof, Martijn E.T. Dollé, Marie A.C. Depuydt, Ilze Bot, Winnie G. Vos, Laura A. Bosmans, Bram W. van Os, Esther Lutgens, Patrick C.N. Rensen, Sander Kooijman
Publikováno v:
EBioMedicine, Vol 93, Iss , Pp 104680- (2023)
Summary: Background: Circadian disturbance (CD) is the consequence of a mismatch between endogenous circadian rhythms, behaviour, and/or environmental cycles, and frequently occurs during shift work. Shift work has been associated with elevated risk
Externí odkaz:
https://doaj.org/article/7688df68c73a447fbd0ed5759e20db0d
Autor:
Marie A. C. Depuydt, Femke D. Vlaswinkel, Esmeralda Hemme, Lucie Delfos, Mireia N. A. Bernabé Kleijn, Peter J. van Santbrink, Amanda C. Foks, Bram Slütter, Johan Kuiper, Ilze Bot
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-10 (2022)
Abstract Mast cells have been associated with the progression and destabilization of advanced atherosclerotic plaques. Reducing intraplaque mast cell accumulation upon atherosclerosis progression could be a potent therapeutic strategy to limit plaque
Externí odkaz:
https://doaj.org/article/f05e69fe5f0f4c9a842ad1a220d94908
Autor:
Eva van Ingen, Amanda C. Foks, Tamar Woudenberg, M. Leontien van der Bent, Alwin de Jong, Philipp J. Hohensinner, Johann Wojta, Ilze Bot, Paul.H.A. Quax, Anne Yaël Nossent
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 26, Iss , Pp 1228-1239 (2021)
We have previously shown that treatment with third-generation antisense oligonucleotides against miR-494-3p (3GA-494) reduces atherosclerotic plaque progression and stabilizes lesions, both in early and established plaques, with reduced macrophage co
Externí odkaz:
https://doaj.org/article/3c732ba897314891bf7651163691b08a
Autor:
Hidde Douna, J. de Mol, Jacob Amersfoort, Frank H. Schaftenaar, Mate G. Kiss, Bianca E. Suur, Mara J. Kroner, Christoph J. Binder, Ilze Bot, Gijs H. M. Van Puijvelde, Johan Kuiper, Amanda C. Foks
Publikováno v:
Frontiers in Cardiovascular Medicine, Vol 9 (2022)
B and T cells are interconnected in the T follicular helper—germinal center B cell (TFH-GC B cell) axis, which is hyperactive during atherosclerosis development and loss of control along this axis results in exacerbated atherosclerosis. Inhibition
Externí odkaz:
https://doaj.org/article/b7e329b21fe3497880611ebc48962b59
Autor:
Eva van Ingen, Amanda C. Foks, Mara J. Kröner, Johan Kuiper, Paul H.A. Quax, Ilze Bot, Anne Yaël Nossent
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 18, Iss , Pp 638-649 (2019)
We have previously shown that third-generation antisense (3GA) inhibition of 14q32 microRNA (miRNA)-494 reduced early development of atherosclerosis. However, patients at risk of atherosclerotic complications generally present with advanced and unsta
Externí odkaz:
https://doaj.org/article/c0ecfbcecf4a4e57b8835ececd858d65
Autor:
Hendrika W. Grievink, Virginia Smit, Robin A. F. Verwilligen, Mireia N. A. Bernabé Kleijn, Diede Smeets, Christoph J. Binder, Hideo Yagita, Matthijs Moerland, Johan Kuiper, Ilze Bot, Amanda C. Foks
Publikováno v:
Frontiers in Cardiovascular Medicine, Vol 8 (2021)
Aim: Signaling through the coinhibitory programmed death (PD)-1/PD-L1 pathway regulates T cell responses and can inhibit ongoing immune responses. Inflammation is a key process in the development of atherosclerosis, the underlying cause for the major
Externí odkaz:
https://doaj.org/article/8a68e6a63e3b4c6fa29e0e4dced398a7
Autor:
Annemarie Aarup, Carsten H. Nielsen, Line S. Bisgaard, Ilze Bot, Henrik H. El-Ali, Andreas Kjaer, Lars B. Nielsen, Tanja X. Pedersen
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-8 (2017)
Abstract Atherosclerotic cardiovascular disease is a major complication of chronic kidney disease (CKD). CKD leads to uremia, which modulates the phenotype of aortic smooth muscle cells (SMCs). Phenotypic modulation of SMCs plays a key role in accele
Externí odkaz:
https://doaj.org/article/c01d0b83ed9c46878998b6f64f53187a
Autor:
Lieve Temmerman, Marijke M. Westra, Ilze Bot, Bart J. M. van Vlijmen, Niek van Bree, Martine Bot, Kim L. L. Habets, Tom G. H. Keulers, Johan van der Vlag, Thomas G. Cotter, Theo J. C. van Berkel, Erik A. L. Biessen
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-11 (2017)
Abstract Proapoptotic Bcl-2 family member Bim is particularly relevant for deletion of autoreactive and activated T and B cells, implicating Bim in autoimmunity. As atherosclerosis is a chronic inflammatory process with features of autoimmune disease
Externí odkaz:
https://doaj.org/article/03205742549a4e9196533178b4a8d0fd