Výsledky vyhledávání - "Ilyas Chachoua"

Akademický článek

Editorial: Non-coding RNAs as emerging players in the development, diagnosis, and treatment of cancer

Publikováno v: Frontiers in Molecular Biosciences, Vol 11 (2024)

Externí odkaz: https://doaj.org/article/4d7d7c02bac643cf999fc6c563554db0

Akademický článek

Oncogenic CALR mutant C-terminus mediates dual binding to the thrombopoietin receptor triggering complex dimerization and activation

Autor: Nicolas Papadopoulos, Audrey Nédélec, Allison Derenne, Teodor Asvadur Şulea, Christian Pecquet, Ilyas Chachoua, Gaëlle Vertenoeil, Thomas Tilmant, Andrei-Jose Petrescu, Gabriel Mazzucchelli, Bogdan I. Iorga, Didier Vertommen, Stefan N. Constantinescu

Publikováno v: Nature Communications, Vol 14, Iss 1, Pp 1-16 (2023)

In myeloproliferative neoplasms, frameshift mutants of calreticulin turn into rogue cytokines by inducing constitutive activation of the Thrombopoietin Receptor (TpoR). Here, the authors define how mutant calreticulin acquires specificity for TpoR bi

Externí odkaz: https://doaj.org/article/2608cc9507e54cfda715fbc3e86b7d63

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Akademický článek

Recent Advances towards the Understanding of Secondary Acute Myeloid Leukemia Progression

Autor: Scott Auerbach, Beana Puka, Upendarrao Golla, Ilyas Chachoua

Publikováno v: Life, Vol 14, Iss 3, p 309 (2024)

Secondary acute myeloid leukemia (sAML) is a heterogeneous malignant hematopoietic disease that arises either from an antecedent hematologic disorder (AHD) including myelodysplastic syndromes (MDS), myeloproliferative neoplasms (MPN), aplastic anemia

Externí odkaz: https://doaj.org/article/5cfabfbae24846f39388eef1f0062392

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Akademický článek

Canonical WNT signaling-dependent gating of MYC requires a noncanonical CTCF function at a distal binding site

Autor: Ilyas Chachoua, Ilias Tzelepis, Hao Dai, Jia Pei Lim, Anna Lewandowska-Ronnegren, Felipe Beccaria Casagrande, Shuangyang Wu, Johanna Vestlund, Carolina Diettrich Mallet de Lima, Deeksha Bhartiya, Barbara A. Scholz, Mirco Martino, Rashid Mehmood, Anita Göndör

Publikováno v: Nature Communications, Vol 13, Iss 1, Pp 1-13 (2022)

Gene-gating of a MYC oncogenic super-enhancer (OSE) increases its expression in colon cancer cells in a poorly understood process. Here the authors show that MYC gating requires a CTCF binding site (CTCFBS) within the OSE that directs the stepwise tr

Externí odkaz: https://doaj.org/article/893a77cc51f74de0b36357c417ac2c2c

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Structural Basis of Oncogenesis by Mutants of Calreticulin

Autor: Stefan N. Constantinescu, Nicolas Papadopoulos, Audrey Nédélec, Allison Derenne, Teodor Asvadur Şulea, Christian Pecquet, Ilyas Chachoua, Gaëlle Vertenoeil, Thomas Tilmant, Andrei-Jose Petrescu, Gabriel Mazuccheli, Didier Vertommen

Calreticulin (CALR) is a master lectin chaperone that normally guides the proper folding of integral membrane proteins in the endoplasmic reticulum. In healthy cells, CALR transiently and non-specifically interacts with thousands of immature N-glycos

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8b393c57f4e2df7456bcef826c4abfd8
https://doi.org/10.21203/rs.3.rs-1605601/v1

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WNT signaling and AHCTF1 promote oncogenic MYC expression through super-enhancer-mediated gene gating

Autor: Mirco Martino, Rashid Mehmood, Honglei Zhao, Barbara A. Scholz, Andrej Nikoshkov, Emmanouil G. Sifakis, Carolina Diettrich Mallet de Lima, Anita Göndör, Ilyas Chachoua, Noriyuki Sumida, Deeksha Bhartiya, Rolf Ohlsson, Ilias Tzelepis

Publikováno v: Nature Genetics. 51:1723-1731

WNT signaling activates MYC expression in cancer cells. Here we report that this involves an oncogenic super-enhancer-mediated tethering of active MYC alleles to nuclear pores to increase transcript export rates. As the decay of MYC transcripts is mo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::bb78806882c88302b682c750a7e72a7c
https://doi.org/10.1038/s41588-019-0535-3

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MPL mutations in essential thrombocythemia uncover a common path of activation with eltrombopag dependent on W491

Autor: Jean-Marc Zini, Serge Carillo, Benjamin Papoular, Stefan N. Constantinescu, Emilie Leroy, Bruno Cassinat, Ilyas Chachoua, Leila N. Varghese, Steven O. Smith, Gabriel Levy, Jean-Philippe Defour

Publikováno v: Blood
Blood, American Society of Hematology, 2020, 135 (12), pp.948-953. ⟨10.1182/blood.2019003240⟩
Blood, Vol. 135, no. 12, p. 948-953 (2020)

Mutations in the MPL gene encoding the human thrombopoietin receptor (TpoR) drive sporadic and familial essential thrombocythemias (ETs). We identified 2 ET patients harboring double mutations in cis in MPL, namely, L498W-H499C and H499Y-S505N. Using

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f7a7f8fb43fc4232ec72a207873c81a
https://hal.umontpellier.fr/hal-03351305

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A p53-JAK-STAT connection involved in myeloproliferative neoplasm pathogenesis and progression to secondary acute myeloid leukemia

Autor: Christian Pecquet, William Vainchenker, Harsh Goyal, Ilyas Chachoua, Stefan N. Constantinescu

Publikováno v: Blood Reviews, Vol. 42, p. 100712 [1-7] (2020)

Since the discovery of JAK2 V617F as a highly prevalent somatic acquired mutation in the majority of myeloproliferative neoplasms (MPNs), it has become clear that these diseases are driven by pathologic activation of JAK2 and eventually of STAT5 and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2d58621aae39d7d5a7f2a1d03b30d722
https://doi.org/10.1016/j.blre.2020.100712

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Calreticulin mutants as oncogenic rogue chaperones for TpoR and traffic-defective pathogenic TpoR mutants

Publikováno v: Blood, Vol. 133, no. 25, p. 2669-2681 (2019)

Calreticulin (CALR) +1 frameshift mutations in exon 9 are prevalent in myeloproliferative neoplasms. Mutant CALRs possess a new C-terminal sequence rich in positively charged amino acids, leading to activation of the thrombopoietin receptor (TpoR/MPL

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5fc4fb014fde76029beb226ff051d945
https://pubmed.ncbi.nlm.nih.gov/31221790

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