Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Ilya Sukhanov"'
Autor:
Anastasia Belskaya, Natalia Kurzina, Artem Savchenko, Ilya Sukhanov, Arina Gromova, Raul R. Gainetdinov, Anna Volnova
Publikováno v:
Biomedicines, Vol 12, Iss 6, p 1270 (2024)
Playing a key role in the organization of striatal motor output, the dopamine (DA)-ergic system regulates both innate and complex learned behaviors. Growing evidence clearly indicates the involvement of the DA-ergic system in different forms of repet
Externí odkaz:
https://doaj.org/article/d82e06015fed4d9b9952ec12d1c73f38
Autor:
Elena Cichero, Valeria Francesconi, Beatrice Casini, Monica Casale, Evgeny Kanov, Andrey S. Gerasimov, Ilya Sukhanov, Artem Savchenko, Stefano Espinoza, Raul R. Gainetdinov, Michele Tonelli
Publikováno v:
Pharmaceuticals, Vol 16, Iss 11, p 1632 (2023)
Trace amine-associated receptor 1 (TAAR1) is an attractive target for the design of innovative drugs to be applied in diverse pharmacological settings. Due to a non-negligible structural similarity with endogenous ligands, most of the agonists develo
Externí odkaz:
https://doaj.org/article/838a4c08d80445b0bfd216925fa9f94f
Publikováno v:
Biomedicines, Vol 11, Iss 7, p 1977 (2023)
All antipsychotics currently used in clinic block D2 dopamine receptors. Trace amine-associated receptor 1 is emerging as a new therapeutic target for schizophrenia and several other neuropsychiatric disorders. SEP-363856 (International Nonproprietar
Externí odkaz:
https://doaj.org/article/ff4edba3210347a99e361d5d51064936
Autor:
Artem Savchenko, Giorgia Targa, Zoia Fesenko, Damiana Leo, Raul R. Gainetdinov, Ilya Sukhanov
Publikováno v:
Biomolecules, Vol 13, Iss 5, p 806 (2023)
The key element of dopamine (DA) neurotransmission is undoubtedly DA transporter (DAT), a transmembrane protein responsible for the synaptic reuptake of the mediator. Changes in DAT’s function can be a key mechanism of pathological conditions assoc
Externí odkaz:
https://doaj.org/article/94a1467c365b4a11af622c42960bca3b
Autor:
Artem Savchenko, Carina Müller, Jana Lubec, Damiana Leo, Volker Korz, Leila Afjehi-Sadat, Jovana Malikovic, Fernando J. Sialana, Gert Lubec, Ilya Sukhanov
Publikováno v:
Frontiers in Psychiatry, Vol 13 (2022)
Dopamine (DA) is critically involved in different functions of the central nervous system (CNS) including control of voluntary movement, affect, reward, sleep, and cognition. One of the key components of DA neurotransmission is DA reuptake by the DA
Externí odkaz:
https://doaj.org/article/0efc09e823854a73b25219113ef3eb7e
Autor:
Ilya Sukhanov, Artem Dorotenko, Zoia Fesenko, Artem Savchenko, Evgeniya V. Efimova, Mikael S. Mor, Irina V. Belozertseva, Tatyana D. Sotnikova, Raul R. Gainetdinov
Publikováno v:
Biomolecules, Vol 13, Iss 1, p 9 (2022)
Parkinson’s disease is the second most common neurodegenerative pathology. Due to the limitations of existing therapeutic approaches, novel anti-parkinsonian medicines with non-dopamine mechanisms of action are clearly needed. One of the promising
Externí odkaz:
https://doaj.org/article/c1b30259947a4a0a93e8ff23764eb869
Autor:
Mikhail Krasavin, Alexey Lukin, Ilya Sukhanov, Andrey S. Gerasimov, Savelii Kuvarzin, Evgeniya V. Efimova, Mariia Dorofeikova, Anna Nichugovskaya, Andrey Matveev, Kirill Onokhin, Konstantin Zakharov, Maxim Gureev, Raul R. Gainetdinov
Publikováno v:
Biomolecules, Vol 12, Iss 11, p 1650 (2022)
A focused in-house library of about 1000 compounds comprising various heterocyclic motifs in combination with structural fragments similar to β-phenylethylamine or tyramine was screened for the agonistic activity towards trace amine-associated recep
Externí odkaz:
https://doaj.org/article/08fe6a56360a4de292d962edb7537ab5
Autor:
Stefano Espinoza, Ilya Sukhanov, Evgeniya V. Efimova, Alena Kozlova, Kristina A. Antonova, Placido Illiano, Damiana Leo, Natalia Merkulyeva, Daria Kalinina, Pavel Musienko, Anna Rocchi, Liudmila Mus, Tatiana D. Sotnikova, Raul R. Gainetdinov
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 13 (2020)
Trace amine-associated receptors (TAARs) are a class of G-protein-coupled receptors found in mammals. While TAAR1 is expressed in several brain regions, all the other TAARs have been described mainly in the olfactory epithelium and the glomerular lay
Externí odkaz:
https://doaj.org/article/4a6b41f442ce4632b33685dd4a83d9a5
Publikováno v:
Neural Regeneration Research, Vol 13, Iss 12, Pp 2091-2093 (2018)
Externí odkaz:
https://doaj.org/article/e974a6cb54264963ab66203dd9d5af7e
Autor:
Vincent M. Lam, Catharine A. Mielnik, Corey Baimel, Pieter Beerepoot, Stefano Espinoza, Ilya Sukhanov, Wendy Horsfall, Raul R. Gainetdinov, Stephanie L. Borgland, Amy J. Ramsey, Ali Salahpour
Publikováno v:
Frontiers in Pharmacology, Vol 9 (2018)
The trace amine associated receptor 1 (TAAR1) is a G-protein coupled receptor expressed in the monoaminergic regions of the brain, and represents a potential novel therapeutic target for the treatment of neurological disorders. While selective agonis
Externí odkaz:
https://doaj.org/article/72a50198b8cd4b4489d0062a3926c619