Zobrazeno 1 - 10
of 58
pro vyhledávání: '"Ilya Ruvinsky"'
Autor:
Russell N. Burkhardt, Alexander B. Artyukhin, Erin Z. Aprison, Brian J. Curtis, Bennett W. Fox, Andreas H. Ludewig, Diana Fajardo Palomino, Jintao Luo, Amaresh Chaturbedi, Oishika Panda, Chester J. J. Wrobel, Victor Baumann, Douglas S. Portman, Siu Sylvia Lee, Ilya Ruvinsky, Frank C. Schroeder
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-15 (2023)
Biological sex affects all aspects of animal physiology. Using the model C. elegans, the authors show that metabolomes are highly sex-specific and include a vast space of yet unidentified metabolites that may control development and lifespan.
Externí odkaz:
https://doaj.org/article/ee59faf2849443c2ad2e5ad357aac4f5
Autor:
Erin Z Aprison, Ilya Ruvinsky
Publikováno v:
PLoS Genetics, Vol 11, Iss 12, p e1005729 (2015)
Pheromones are secreted molecules that mediate animal communications. These olfactory signals can have substantial effects on physiology and likely play important roles in organismal survival in natural habitats. Here we show that a blend of two asca
Externí odkaz:
https://doaj.org/article/4c4825341f3e4998b54aceb7eccc7561
Publikováno v:
PLoS Genetics, Vol 11, Iss 5, p e1005268 (2015)
Gene regulatory information guides development and shapes the course of evolution. To test conservation of gene regulation within the phylum Nematoda, we compared the functions of putative cis-regulatory sequences of four sets of orthologs (unc-47, u
Externí odkaz:
https://doaj.org/article/1a102d365dd740d498485dda487daf16
Publikováno v:
PLoS ONE, Vol 10, Iss 12, p e0145925 (2015)
Natural environments are considerably more variable than laboratory settings and often involve transient exposure to stressful conditions. To fully understand how organisms have evolved to respond to any given stress, prior experience must therefore
Externí odkaz:
https://doaj.org/article/aaa4ea5968dd466eb6907063b7d8b912
Autor:
Antoine Barrière, Ilya Ruvinsky
Publikováno v:
PLoS Genetics, Vol 10, Iss 6, p e1004435 (2014)
Because there is considerable variation in gene expression even between closely related species, it is clear that gene regulatory mechanisms evolve relatively rapidly. Because primary sequence conservation is an unreliable proxy for functional conser
Externí odkaz:
https://doaj.org/article/e150739e083e46639a540adedac3c63f
Autor:
Erin Z Aprison, Ilya Ruvinsky
Publikováno v:
PLoS ONE, Vol 9, Iss 8, p e105513 (2014)
To ensure long-term reproductive success organisms have to cope with harsh environmental extremes. A reproductive strategy that simply maximizes offspring production is likely to be disadvantageous because it could lead to a catastrophic loss of fecu
Externí odkaz:
https://doaj.org/article/f498e3b970194664968bcddf522c02fa
Publikováno v:
PLoS Genetics, Vol 8, Iss 9, p e1002961 (2012)
Phenotypes that appear to be conserved could be maintained not only by strong purifying selection on the underlying genetic systems, but also by stabilizing selection acting via compensatory mutations with balanced effects. Such coevolution has been
Externí odkaz:
https://doaj.org/article/ec15537ca3ac4d9da1bd75b1362b2fb1
Autor:
Patrick D McMullen, Erin Z Aprison, Peter B Winter, Luis A N Amaral, Richard I Morimoto, Ilya Ruvinsky
Publikováno v:
PLoS Computational Biology, Vol 8, Iss 1, p e1002338 (2012)
A major goal of systems biology is to understand how organism-level behavior arises from a myriad of molecular interactions. Often this involves complex sets of rules describing interactions among a large number of components. As an alternative, we h
Externí odkaz:
https://doaj.org/article/6bd5a0e15af147ab9a292c295eac3f57
Autor:
Kacy L Gordon, Ilya Ruvinsky
Publikováno v:
PLoS Genetics, Vol 8, Iss 1, p e1002432 (2012)
Perennial questions of evolutionary biology can be applied to gene regulatory systems using the abundance of experimental data addressing gene regulation in a comparative context. What is the tempo (frequency, rate) and mode (way, mechanism) of trans
Externí odkaz:
https://doaj.org/article/21aa614f1e0747cab05e8d52ce06dedb
Publikováno v:
PLoS Genetics, Vol 7, Iss 6, p e1002095 (2011)
Different functional constraints contribute to different evolutionary rates across genomes. To understand why some sequences evolve faster than others in a single cis-regulatory locus, we investigated function and evolutionary dynamics of the promote
Externí odkaz:
https://doaj.org/article/607dba46a9ca43cbae41b1c279419536