Loss of Transcriptional Repression by BCL6 Confers Insulin Sensitivity in the Setting of Obesity

Autor: Madhavi D. Senagolage, Meredith A. Sommars, Krithika Ramachandran, Christopher R. Futtner, Yasuhiro Omura, Amanda L. Allred, Jianing Wang, Cynthia Yang, Daniele Procissi, Ronald M. Evans, Xianlin Han, Ilya R. Bederman, Grant D. Barish

Publikováno v: Cell Reports, Vol 25, Iss 12, Pp 3283-3298.e6 (2018)

Summary: Accumulation of visceral adiposity is directly linked to the morbidity of obesity, while subcutaneous body fat is considered more benign. We have identified an unexpected role for B cell lymphoma 6 (BCL6), a critical regulator of immunity, i

Externí odkaz: https://doaj.org/article/23f24c5f8f9c4498af7deb99b8eddc75

Dynamic repression by BCL6 controls the genome-wide liver response to fasting and steatosis

Autor: Meredith A Sommars, Krithika Ramachandran, Madhavi D Senagolage, Christopher R Futtner, Derrik M Germain, Amanda L Allred, Yasuhiro Omura, Ilya R Bederman, Grant D Barish

Publikováno v: eLife, Vol 8 (2019)

Transcription is tightly regulated to maintain energy homeostasis during periods of feeding or fasting, but the molecular factors that control these alternating gene programs are incompletely understood. Here, we find that the B cell lymphoma 6 (BCL6

Externí odkaz: https://doaj.org/article/31b0386732914031a75b86d14e851146

Time course of hepatic gluconeogenesis during hindlimb suspension unloading

Autor: Ilya R, Bederman, Visvanathan, Chandramouli, Yana, Sandlers, Leigh, Henderson, Marco E, Cabrera

Publikováno v: Experimental physiology. 98(1)

The goal of this work was to determine the time-dependent changes in fractional hepatic gluconeogenesis (GNG) during conditions of hindlimb suspension unloading (HSU), a 'ground-based' method for inducing muscular atrophy to simulate space flight. We

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::c7187301b828608fcd1f983c8d50e76b
https://pubmed.ncbi.nlm.nih.gov/22707505

In vitro modeling of fatty acid synthesis under conditions simulating the zonation of lipogenic [13C]acetyl-CoA enrichment in the liver

Autor: Ilya R. Bederman, Takhar Kasumov, Aneta E. Reszko, France David, Henri Brunengraber, Joanne K. Kelleher

Publikováno v: The Journal of biological chemistry. 279(41)

In the companion report (Bederman, I. R., Reszko, A. E., Kasumov, T., David, F., Wasserman, D. H., Kelleher, J. K., and Brunengraber, H. (2004) J. Biol. Chem. 279, 43207-43216), we demonstrated that, when the hepatic pool of lipogenic acetyl-CoA is l

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7353ce8df29111a2fad3a93b2bf62e2e
https://pubmed.ncbi.nlm.nih.gov/15284243

Zonation of acetate labeling across the liver: implications for studies of lipogenesis by MIDA

Autor: Michelle A. Puchowicz, Ilya R. Bederman, Blandine Comte, Dawei Yang, France David, Eric Stone, Kareem Jabbour, David H. Wasserman, Henri Brunengraber

Publikováno v: AJP-Endocrinology and Metabolism
AJP-Endocrinology and Metabolism, American Physiological Society, 1999, 277 (6), pp.E1022-E1027. ⟨10.1152/ajpendo.1999.277.6.E1022⟩

Measurement of fractional lipogenesis by mass isotopomer distribution analysis (MIDA) of fatty acids or cholesterol labeled from [13C]acetate assumes constant enrichment of lipogenic acetyl-CoA in all hepatocytes. This would not be the case if uptake

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9384e78e28eb71657b1d6033f8a7b7a2
https://pubmed.ncbi.nlm.nih.gov/10600790