Zobrazeno 1 - 10
of 72
pro vyhledávání: '"Ilya Okun"'
Autor:
Martin F Strand, Steven R Wilson, Jennifer L Dembinski, Daniel D Holsworth, Alexander Khvat, Ilya Okun, Dirk Petersen, Stefan Krauss
Publikováno v:
PLoS ONE, Vol 6, Iss 6, p e19904 (2011)
Hedgehog (Hh) signaling is over-activated in several solid tumors where it plays a central role in cell growth, stroma recruitment and tumor progression. In the Hh signaling pathway, the Smoothened (SMO) receptor comprises a primary drug target with
Externí odkaz:
https://doaj.org/article/881d0f9f884f4c36b8cea2f62c44edd2
Autor:
Vladimir A. Aladinskiy, Ramiz Salimov, Alexandre V. Ivachtchenko, Angela G. Koryakova, Ruben Karapetyan, Ilya Bezprozvanny, Yan A. Ivanenkov, Oleg D. Mitkin, Ilya Okun, Andrey Alexandrovich Ivashchenko
Publikováno v:
Journal of Alzheimer's Disease. 58:1043-1063
Discovery of 5-HT6 receptor subtype and its exclusive localization within the central nervous system led to extensive investigations of its role in Alzheimer's disease, schizophrenia, and obesity. In the present study, we present preclinical evaluati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::37309bd38e34efbc81462e1cd36fc714
https://doi.org/10.3233/jad-161262
https://doi.org/10.3233/jad-161262
Publikováno v:
Journal of Alzheimer's Disease
Lack of efficacy of many new highly selective and specific drug candidates in treating diseases with poorly understood or complex etiology, as are many of central nervous system (CNS) diseases, encouraged an idea of developing multi-modal (multi-targ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f48852924d3e5f27385a78b602b3024
https://doi.org/10.3233/jad-151146
https://doi.org/10.3233/jad-151146
Autor:
O. M. Korzinov, V. Yu. Vedenskii, Vadim V. Bichko, Andrey Alexandrovich Ivashchenko, Ya. A. Ivanenkov, Elena A. Bulanova, Oleg D. Mitkin, Ilya Okun, Alexandre Vasilievich Ivachtchenko, I. A. Leneva, V. M. Kisil, Pavel M. Yamanushkin
Publikováno v:
Pharmaceutical Chemistry Journal. 49:151-162
Novel substituted 5-hydroxy-2-aminomethyl-1H-indole-3-carboxylic acids and their derivatives were synthesized. The antiviral properties of these compounds were investigated in relation to bovine viral diarrhea virus (BVDV), hepatitis C virus (HCV), a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::589f9e3df4ea29e4bf8188fd2ea618b8
https://doi.org/10.1007/s11094-015-1244-6
https://doi.org/10.1007/s11094-015-1244-6
Autor:
E. S. Golovina, Alexandre Vasilievich Ivachtchenko, Oleg D. Mitkin, Ilya Okun, Madina G. Kadieva
Publikováno v:
Pharmaceutical Chemistry Journal. 48:646-660
In continuation of research and development of new high-efficacy drugs based on 5-HT6 receptor antagonists for the treatment of CNS disorders, we synthesized a series of new 3-(phenylsulfonyl)quinoline derivatives, performed their molecular docking,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::86cfd7cb7234c903cea12913820d26a0
https://doi.org/10.1007/s11094-015-1164-5
https://doi.org/10.1007/s11094-015-1164-5
Autor:
Ya. A. Ivanenkov, Pavel M. Yamanushkin, V. M. Kisil, A. V. Ivashchenko, Ilya Okun, Andrey Alexandrovich Ivashchenko, Oleg D. Mitkin, O. M. Korzinov, V. Yu. Vedenskii, Elena A. Bulanova, I. A. Leneva, V. V. Bychko
Publikováno v:
Pharmaceutical Chemistry Journal. 48:569-581
New substituted ethyl esters of 2,4-bis-aminomethyl-5-hydroxy-1H-indole-3-carboxylic acids, 8-aminomethyl-2-methyl-2,3-dihydro-1H,7H-[1,3]-oxazino-[5,6-e]indole-9-carboxylic acids, and members of the previously unknown 4,5-dihydro-1H-pyrrolo[4,3,2-de
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ab6ba4b403608202e67e772c93b5a88a
https://doi.org/10.1007/s11094-014-1153-0
https://doi.org/10.1007/s11094-014-1153-0
Autor:
V. V. Bychko, O. M. Korzinov, Oleg D. Mitkin, V. Yu. Vedenskii, Elena A. Bulanova, Ilya Okun, I. A. Leneva, V. M. Kisil, Pavel M. Yamanushkin, A. V. Ivashchenko
Publikováno v:
Pharmaceutical Chemistry Journal. 47:636-650
New substituted ethyl 5-hydroxy-1,2-dimethyl-1H-indole-3-carboxylates and 7,8-dimethyl-1,2,3,7-tetrahydro[1,3]oxazino[5,6-e]indole-9-carboxylates including arbidol analogs in addition to 6-hydroxy-1-methyl-7-pyridin-3-yl-4,5-dihydropyrrolo[4,3,2-de]i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3e23f0986ebe8fd93a1ef424e142f867
https://doi.org/10.1007/s11094-014-1024-8
https://doi.org/10.1007/s11094-014-1024-8
Autor:
Ilya Okun, Oleg D. Mitkin, Madina G. Kadieva, S. E. Tkachenko, Elena S. Golovina, Alexandre V. Ivachtchenko
Publikováno v:
Bioorganic & Medicinal Chemistry. 21:4614-4627
Substituted diphenyl sulfones (10a–n) were synthesised, and the structures were confirmed by NMR, LC–MS and X-ray crystallography. Their antagonistic activities towards 5-HT6 receptor were assessed in a cell-based functional assay. Diphenyl sulfo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e08f5b2180dfe9917ccadbf4f5d8ce9
https://doi.org/10.1016/j.bmc.2013.05.040
https://doi.org/10.1016/j.bmc.2013.05.040
Publikováno v:
Pharmaceutical Chemistry Journal. 47:12-19
A series of new 2-substituted 8-methyl-5-(2-pyridinylethyl)-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indoles have been synthesized. Their activity profiles were studied on a broad panel of therapeutic targets including GPC-receptors, ion channels, and neur
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0921aea1a0be05757b9e302e2ec78b3f
https://doi.org/10.1007/s11094-013-0887-4
https://doi.org/10.1007/s11094-013-0887-4
Autor:
Laurent Meijer, Narkiss Pressburger, Wiebke Fugel, Ilya Okun, Anselm Erich Oberholzer, Lutz Preu, Ron Dzikowski, Morgane Ratin, Blandine Baratte, Sebastian Kruggel, B Gschloessl, Christian Doerig, Conrad Kunick, Laurence H. Pearl, Thomas Lemcke
Publikováno v:
Journal of Medicinal Chemistry; Vol 56
Plasmodium falciparum is the infective agent responsible for malaria tropica. The glycogen synthase kinase-3 of the parasite (PfGSK-3) was suggested as a potential biological target for novel antimalarial drugs. Starting from hit structures identifie
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4569ae9ecb15661f2273c2ee7ed4c6c5