Zobrazeno 1 - 10
of 35
pro vyhledávání: '"Ilya M. Flyamer"'
Autor:
Stefano Gnan, Ilya M. Flyamer, Kyle N. Klein, Eleonora Castelli, Alexander Rapp, Andreas Maiser, Naiming Chen, Patrick Weber, Elin Enervald, M. Cristina Cardoso, Wendy A. Bickmore, David M. Gilbert, Sara C. B. Buonomo
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-10 (2021)
How nuclear architecture overall affects the replication-timing programme is not yet clear. Here the authors reveal RIF1’s dual role as a chromatin-interaction scaffold and regulator of replication timing that allows the coordination of these two a
Externí odkaz:
https://doaj.org/article/051ec9ea54774968bffcfc289db433ad
Autor:
Sergey V. Ulianov, Vlada V. Zakharova, Aleksandra A. Galitsyna, Pavel I. Kos, Kirill E. Polovnikov, Ilya M. Flyamer, Elena A. Mikhaleva, Ekaterina E. Khrameeva, Diego Germini, Mariya D. Logacheva, Alexey A. Gavrilov, Alexander S. Gorsky, Sergey K. Nechaev, Mikhail S. Gelfand, Yegor S. Vassetzky, Alexander V. Chertovich, Yuri Y. Shevelyov, Sergey V. Razin
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
Genomes are partitioned into topologically associating domains (TADs). Here the authors present single-nucleus Hi-C maps in Drosophila at 10 kb resolution, demonstrating the presence of chromatin compartments in individual nuclei, and partitioning of
Externí odkaz:
https://doaj.org/article/8dcfb2d70fc24ab89ca4dad46c6324c9
Autor:
Donnchadh S. Dunican, Heidi K. Mjoseng, Leanne Duthie, Ilya M. Flyamer, Wendy A. Bickmore, Richard R. Meehan
Publikováno v:
BMC Biology, Vol 18, Iss 1, Pp 1-21 (2020)
Abstract Background Thousands of mammalian promoters are defined by co-enrichment of the histone tail modifications H3K27me3 (repressive) and H3K4me3 (activating) and are thus termed bivalent. It was previously observed that bivalent genes in human E
Externí odkaz:
https://doaj.org/article/cc3fa85d4d5d449588d39054315791cf
Autor:
Sergey V. Ulianov, Semen A. Doronin, Ekaterina E. Khrameeva, Pavel I. Kos, Artem V. Luzhin, Sergei S. Starikov, Aleksandra A. Galitsyna, Valentina V. Nenasheva, Artem A. Ilyin, Ilya M. Flyamer, Elena A. Mikhaleva, Mariya D. Logacheva, Mikhail S. Gelfand, Alexander V. Chertovich, Alexey A. Gavrilov, Sergey V. Razin, Yuri Y. Shevelyov
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-11 (2019)
The role of the nuclear lamina (NL) in chromatin architecture is still poorly understood. Here, the authors provide evidence that disruption of the NL in Drosophila cells leads to overall chromatin compaction and repositioning from the nuclear envelo
Externí odkaz:
https://doaj.org/article/019c5aaf61ed41efb63d52b8af38836b
Autor:
Sergey V. Ulianov, Aleksandra A. Galitsyna, Ilya M. Flyamer, Arkadiy K. Golov, Ekaterina E. Khrameeva, Maxim V. Imakaev, Nezar A. Abdennur, Mikhail S. Gelfand, Alexey A. Gavrilov, Sergey V. Razin
Publikováno v:
Epigenetics & Chromatin, Vol 10, Iss 1, Pp 1-19 (2017)
Abstract Background In homeotherms, the alpha-globin gene clusters are located within permanently open genome regions enriched in housekeeping genes. Terminal erythroid differentiation results in dramatic upregulation of alpha-globin genes making the
Externí odkaz:
https://doaj.org/article/5faf277341c547219a288c47cf1b9b1f
Autor:
Katy McLaughlin, Ilya M. Flyamer, John P. Thomson, Heidi K. Mjoseng, Ruchi Shukla, Iain Williamson, Graeme R. Grimes, Robert S. Illingworth, Ian R. Adams, Sari Pennings, Richard R. Meehan, Wendy A. Bickmore
Publikováno v:
Cell Reports, Vol 29, Iss 7, Pp 1974-1985.e6 (2019)
Summary: The DNA hypomethylation that occurs when embryonic stem cells (ESCs) are directed to the ground state of naive pluripotency by culturing in two small molecule inhibitors (2i) results in redistribution of polycomb (H3K27me3) away from its tar
Externí odkaz:
https://doaj.org/article/494966c0bb4449d6817be1b988d20ad1
Autor:
Open2C, Nezar Abdennur, Sameer Abraham, Geoffrey Fudenberg, Ilya M Flyamer, Aleksandra A Galitsyna, Anton Goloborodko, Maxim Imakaev, Betul A Oksuz, Sergey V Venev, Yao Xiao
Publikováno v:
PLoS Computational Biology, Vol 20, Iss 5, p e1012067 (2024)
Chromosome conformation capture (3C) technologies reveal the incredible complexity of genome organization. Maps of increasing size, depth, and resolution are now used to probe genome architecture across cell states, types, and organisms. Larger datas
Externí odkaz:
https://doaj.org/article/70d4fa2637ed41ecb2f8c041c46c5ff4
Autor:
Bart J. H. Dequeker, Matthias J. Scherr, Hugo B. Brandão, Johanna Gassler, Sean Powell, Imre Gaspar, Ilya M. Flyamer, Aleksandar Lalic, Wen Tang, Roman Stocsits, Iain F. Davidson, Jan-Michael Peters, Karl E. Duderstadt, Leonid A. Mirny, Kikuë Tachibana
Publikováno v:
Nature
Eukaryotic genomes are compacted into loops and topologically associating domains (TADs)1–3, which contribute to transcription, recombination and genomic stability4,5. Cohesin extrudes DNA into loops that are thought to lengthen until CTCF boundari
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9fc53de26f6a5b4349e849f02bf18469
https://doi.org/10.1038/s41586-022-04730-0
https://doi.org/10.1038/s41586-022-04730-0
Contacts between enhancers and promoters are thought to relate to their ability to activate transcription. Investigating mechanisms that drive such chromatin interactions is therefore important for understanding gene regulation. Here, we have determi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1e7c99ece0fe3c11f2314b8600640207
https://doi.org/10.1101/2022.11.30.518557
https://doi.org/10.1101/2022.11.30.518557
Autor:
Lauren Kane, Iain Williamson, Ilya M. Flyamer, Yatendra Kumar, Robert E. Hill, Laura A. Lettice, Wendy A. Bickmore
Publikováno v:
Kane, L, Williamson, I, Flyamer, I, Kumar, Y, Hill, R E, Lettice, L A & Bickmore, W A 2022, ' Cohesin is required for long-range enhancer action at the Shh locus ', Nature Structural & Molecular Biology, vol. 29, no. 9, pp. 891-897 . https://doi.org/10.1038/s41594-022-00821-8
Nat Struct Mol Biol
Nat Struct Mol Biol
The regulatory landscapes of developmental genes in mammals can be complex, with enhancers spread over many hundreds of kilobases. It has been suggested that three-dimensional genome organisation, particularly topologically associating domains formed
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::005cf46e25b276610ee986e6f1825e97
https://www.pure.ed.ac.uk/ws/files/288068812/Kane_NSMB_accepted.pdf
https://www.pure.ed.ac.uk/ws/files/288068812/Kane_NSMB_accepted.pdf