Zobrazeno 1 - 10
of 139
pro vyhledávání: '"Ilya M, Nasrallah"'
Autor:
Junhao Wen, Zhijian Yang, Ilya M. Nasrallah, Yuhan Cui, Guray Erus, Dhivya Srinivasan, Ahmed Abdulkadir, Elizabeth Mamourian, Gyujoon Hwang, Ashish Singh, Mark Bergman, Jingxuan Bao, Erdem Varol, Zhen Zhou, Aleix Boquet-Pujadas, Jiong Chen, Arthur W. Toga, Andrew J. Saykin, Timothy J. Hohman, Paul M. Thompson, Sylvia Villeneuve, Randy Gollub, Aristeidis Sotiras, Katharina Wittfeld, Hans J. Grabe, Duygu Tosun, Murat Bilgel, Yang An, Daniel S. Marcus, Pamela LaMontagne, Tammie L. Benzinger, Susan R. Heckbert, Thomas R. Austin, Lenore J. Launer, Mark Espeland, Colin L. Masters, Paul Maruff, Jurgen Fripp, Sterling C. Johnson, John C. Morris, Marilyn S. Albert, R. Nick Bryan, Susan M. Resnick, Luigi Ferrucci, Yong Fan, Mohamad Habes, David Wolk, Li Shen, Haochang Shou, Christos Davatzikos
Publikováno v:
Translational Psychiatry, Vol 14, Iss 1, Pp 1-14 (2024)
Abstract Alzheimer’s disease (AD) is associated with heterogeneous atrophy patterns. We employed a semi-supervised representation learning technique known as Surreal-GAN, through which we identified two latent dimensional representations of brain a
Externí odkaz:
https://doaj.org/article/56d631e8319148739bce0f8e8b35d005
Autor:
Mathilde Antoniades, Dhivya Srinivasan, Junhao Wen, Guray Erus, Ahmed Abdulkadir, Elizabeth Mamourian, Randa Melhem, Gyujoon Hwang, Yuhan Cui, Sindhuja Tirumalai Govindarajan, Andrew A. Chen, Zhen Zhou, Zhijian Yang, Jiong Chen, Raymond Pomponio, Susan Sotardi, Yang An, Murat Bilgel, Pamela LaMontagne, Ashish Singh, Tammie Benzinger, Lori Beason-Held, Daniel S. Marcus, Kristine Yaffe, Lenore Launer, John C. Morris, Duygu Tosun, Luigi Ferrucci, R. Nick Bryan, Susan M. Resnick, Mohamad Habes, David Wolk, Yong Fan, Ilya M. Nasrallah, Haochang Shou, Christos Davatzikos
Publikováno v:
EBioMedicine, Vol 109, Iss , Pp 105399- (2024)
Summary: Background: Brain ageing is highly heterogeneous, as it is driven by a variety of normal and neuropathological processes. These processes may differentially affect structural and functional brain ageing across individuals, with more pronounc
Externí odkaz:
https://doaj.org/article/782b783c1fc740c68d12c609c91452e4
Autor:
Zhijian Yang, Junhao Wen, Ahmed Abdulkadir, Yuhan Cui, Guray Erus, Elizabeth Mamourian, Randa Melhem, Dhivya Srinivasan, Sindhuja T. Govindarajan, Jiong Chen, Mohamad Habes, Colin L. Masters, Paul Maruff, Jurgen Fripp, Luigi Ferrucci, Marilyn S. Albert, Sterling C. Johnson, John C. Morris, Pamela LaMontagne, Daniel S. Marcus, Tammie L. S. Benzinger, David A. Wolk, Li Shen, Jingxuan Bao, Susan M. Resnick, Haochang Shou, Ilya M. Nasrallah, Christos Davatzikos
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-16 (2024)
Abstract Disease heterogeneity has been a critical challenge for precision diagnosis and treatment, especially in neurologic and neuropsychiatric diseases. Many diseases can display multiple distinct brain phenotypes across individuals, potentially r
Externí odkaz:
https://doaj.org/article/e4408877453444c49479a4dba3887d8a
Autor:
Thomas F. Tropea, Teresa Waligorska, Sharon X. Xie, Ilya M. Nasrallah, Katheryn A. Q. Cousins, John Q. Trojanowski, Murray Grossman, David J. Irwin, Daniel Weintraub, Edward B. Lee, David A. Wolk, Alice S. Chen‐Plotkin, Leslie M. Shaw, the Alzheimer's Disease Neuroimaging Initiative
Publikováno v:
Annals of Clinical and Translational Neurology, Vol 10, Iss 1, Pp 18-31 (2023)
Abstract Objective To determine if plasma tau phosphorylated at threonine 181 (p‐tau181) distinguishes pathology‐confirmed Alzheimer's disease (AD) from normal cognition (NC) adults, to test if p‐tau181 predicts cognitive and functional decline
Externí odkaz:
https://doaj.org/article/3b999f9709d54025a05894541cc30c3f
Autor:
Mitzi M. Gonzales, Crystal Wiedner, Chen‐Pin Wang, Qianqian Liu, Joshua C. Bis, Zhiguang Li, Jayandra J. Himali, Saptaparni Ghosh, Emy A. Thomas, Danielle M. Parent, Tiffany F. Kautz, Matthew P. Pase, Hugo J. Aparicio, Luc Djoussé, Kenneth J. Mukamal, Bruce M. Psaty, William T. Longstreth Jr, Thomas H. Mosley Jr, Vilmundur Gudnason, Djass Mbangdadji, Oscar L. Lopez, Kristine Yaffe, Stephen Sidney, R. Nick Bryan, Ilya M. Nasrallah, Charles S. DeCarli, Alexa S. Beiser, Lenore J. Launer, Myriam Fornage, Russell P. Tracy, Sudha Seshadri, Claudia L. Satizabal
Publikováno v:
Annals of Clinical and Translational Neurology, Vol 9, Iss 10, Pp 1574-1585 (2022)
Abstract Objective Expression of glial fibrillary acidic protein (GFAP), a marker of reactive astrocytosis, colocalizes with neuropathology in the brain. Blood levels of GFAP have been associated with cognitive decline and dementia status. However, f
Externí odkaz:
https://doaj.org/article/f62e692ace824cb49e09951b82e5f859
Autor:
Zhen Zhou, Hongming Li, Dhivya Srinivasan, Ahmed Abdulkadir, Ilya M. Nasrallah, Junhao Wen, Jimit Doshi, Guray Erus, Elizabeth Mamourian, Nick R. Bryan, David A. Wolk, Lori Beason-Held, Susan M. Resnick, Theodore D. Satterthwaite, Christos Davatzikos, Haochang Shou, Yong Fan
Publikováno v:
NeuroImage, Vol 269, Iss , Pp 119911- (2023)
To learn multiscale functional connectivity patterns of the aging brain, we built a brain age prediction model of functional connectivity measures at seven scales on a large fMRI dataset, consisting of resting-state fMRI scans of 4186 individuals wit
Externí odkaz:
https://doaj.org/article/b2dbf5d0a6594ddcadb3c93f3330cca7
Autor:
Tanweer Rashid, Hangfan Liu, Jeffrey B. Ware, Karl Li, Jose Rafael Romero, Elyas Fadaee, Ilya M. Nasrallah, Saima Hilal, R. Nick Bryan, Timothy M. Hughes, Christos Davatzikos, Lenore Launer, Sudha Seshadri, Susan R. Heckbert, Mohamad Habes
Publikováno v:
Neuroimage: Reports, Vol 3, Iss 1, Pp 100162- (2023)
Deep learning has been demonstrated effective in many neuroimaging applications. However, in many scenarios, the number of imaging sequences capturing information related to small vessel disease lesions is insufficient to support data-driven techniqu
Externí odkaz:
https://doaj.org/article/6d7e694cb4a14c5598006d5df77dee0b
Autor:
Michael Tran Duong, Sandhitsu R. Das, Xueying Lyu, Long Xie, Hayley Richardson, Sharon X. Xie, Paul A. Yushkevich, Alzheimer’s Disease Neuroimaging Initiative (ADNI), David A. Wolk, Ilya M. Nasrallah
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-15 (2022)
In Alzheimer’s disease (AD) tau and neurodegeneration have complex regional relationships. Here, the authors show neuronal hypometabolism discordant with tau burden defines functional resilience or susceptibility to Alzheimer’s pathology via limb
Externí odkaz:
https://doaj.org/article/b6f1e35d4dc8425fb98a9a80d17de6e9
Publikováno v:
NeuroImage: Clinical, Vol 40, Iss , Pp 103513- (2023)
Background: Brain perivascular spaces (PVS) are part of the glymphatic system and facilitate clearance of metabolic byproducts. Since enlarged PVS are associated with vascular health, we tested whether intensive systolic blood pressure (SBP) treatmen
Externí odkaz:
https://doaj.org/article/6519b953e3b34491982cfd9f31ccc003
Autor:
Zhijian Yang, Ilya M. Nasrallah, Haochang Shou, Junhao Wen, Jimit Doshi, Mohamad Habes, Guray Erus, Ahmed Abdulkadir, Susan M. Resnick, Marilyn S. Albert, Paul Maruff, Jurgen Fripp, John C. Morris, David A. Wolk, Christos Davatzikos, iSTAGING Consortium, Baltimore Longitudinal Study of Aging (BLSA), Alzheimer’s Disease Neuroimaging Initiative (ADNI)
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
Alzheimer’s disease is heterogeneous in its neuroimaging and clinical phenotypes. Here the authors present a semi-supervised deep learning method, Smile-GAN, to show four neurodegenerative patterns and two progression pathways providing prognostic
Externí odkaz:
https://doaj.org/article/bc622eef4986462d950294c8155877a6