Synthesis and Anti-Inflammatory Activity of (Z)-4-(2-(3-Oxopiperazin-2-ylidene)acetyl)benzoic Acid

Autor: Maksim V. Dmitriev, Ekaterina E. Khramtsova, Danila Y. Apuskin, Alexander I. Andreev, Ilya I. Kovalenko, Irina V. Mashevskaya, Andrey N. Maslivets

Publikováno v: Molbank, Vol 2024, Iss 1, p M1772 (2024)

Non-steroidal anti-inflammatory drugs (NSAIDs) are an important class of medications; however, they have some drawbacks. We are developing a new NSAID with pronounced anti-inflammatory and analgesic activities and a very low toxicity—(Z)-3-(2-oxo-2

Externí odkaz: https://doaj.org/article/f469282d1b07466ea2450ab5a6745fd6

Interaction of Methylene Blue with Severe Acute Respiratory Syndrome Coronavirus 2 Envelope Revealed by Molecular Modeling.

Autor: Kovalenko I; Faculty of Biology, Lomonosov Moscow State University, Moscow 119234, Russia.; Scientific and Educational Mathematical Center «Sofia Kovalevskaya Northwestern Center for Mathematical Research», Pskov State University, Pskov 180000, Russia., Kholina E; Faculty of Biology, Lomonosov Moscow State University, Moscow 119234, Russia., Fedorov V; Faculty of Biology, Lomonosov Moscow State University, Moscow 119234, Russia., Khruschev S; Faculty of Biology, Lomonosov Moscow State University, Moscow 119234, Russia., Vasyuchenko E; Faculty of Biology, Lomonosov Moscow State University, Moscow 119234, Russia., Meerovich G; Prokhorov General Physics Institute of the Russian Academy of Sciences, Moscow 119991, Russia.; Institute for Physics and Engineering in Biomedicine, National Research Nuclear University 'MEPHI', Moscow 115409, Russia., Strakhovskaya M; Faculty of Biology, Lomonosov Moscow State University, Moscow 119234, Russia.

Publikováno v: International journal of molecular sciences [Int J Mol Sci] 2023 Nov 02; Vol. 24 (21). Date of Electronic Publication: 2023 Nov 02.

Insights into the Formation of Intermolecular Complexes of Fluorescent Probe 10- N -Nonyl Acridine Orange with Cardiolipin and Phosphatidylglycerol in Bacterial Plasma Membrane by Molecular Modeling.

Autor: Kholina E; Faculty of Biology, Lomonosov Moscow State University, 119234 Moscow, Russia., Kovalenko I; Faculty of Biology, Lomonosov Moscow State University, 119234 Moscow, Russia., Rubin A; Faculty of Biology, Lomonosov Moscow State University, 119234 Moscow, Russia., Strakhovskaya M; Faculty of Biology, Lomonosov Moscow State University, 119234 Moscow, Russia.

Publikováno v: Molecules (Basel, Switzerland) [Molecules] 2023 Feb 17; Vol. 28 (4). Date of Electronic Publication: 2023 Feb 17.

Mitochondrial complex II in intestinal epithelial cells regulates T cell-mediated immunopathology.

Autor: Fujiwara H; Department of Internal Medicine, Division of Hematology and Oncology, University of Michigan, Rogel Cancer Center, Ann Arbor, MI, USA., Seike K; Department of Internal Medicine, Division of Hematology and Oncology, University of Michigan, Rogel Cancer Center, Ann Arbor, MI, USA., Brooks MD; Department of Internal Medicine, Division of Hematology and Oncology, University of Michigan, Rogel Cancer Center, Ann Arbor, MI, USA., Mathew AV; Department of Internal Medicine, Division of Nephrology, University of Michigan Health System, Ann Arbor, MI, USA., Kovalenko I; Department of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, MI, USA., Pal A; Department of Radiation Oncology, University of Michigan, Ann Arbor, MI, USA., Lee HJ; Department of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, MI, USA., Peltier D; Department of Pediatrics, Division of Hematology/Oncology and BMT, University of Michigan Health System, Ann Arbor, MI, USA., Kim S; Department of Internal Medicine, Division of Hematology and Oncology, University of Michigan, Rogel Cancer Center, Ann Arbor, MI, USA., Liu C; Department of Pathology and Laboratory Medicine, Rutgers-Robert Wood Johnson Medical School, New Brunswick, NJ, USA., Oravecz-Wilson K; Department of Internal Medicine, Division of Hematology and Oncology, University of Michigan, Rogel Cancer Center, Ann Arbor, MI, USA., Li L; Department of Internal Medicine, Division of Hematology and Oncology, University of Michigan, Rogel Cancer Center, Ann Arbor, MI, USA., Sun Y; Department of Internal Medicine, Division of Hematology and Oncology, University of Michigan, Rogel Cancer Center, Ann Arbor, MI, USA., Byun J; Department of Internal Medicine, Division of Nephrology, University of Michigan Health System, Ann Arbor, MI, USA., Maeda Y; Department of Hematology Oncology and Respiratory Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan., Wicha MS; Department of Internal Medicine, Division of Hematology and Oncology, University of Michigan, Rogel Cancer Center, Ann Arbor, MI, USA., Saunders TL; Transgenic Animal Model Core, University of Michigan Medical School, Ann Arbor, MI, USA., Rehemtulla A; Department of Radiation Oncology, University of Michigan, Ann Arbor, MI, USA., Lyssiotis CA; Department of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, MI, USA., Pennathur S; Department of Internal Medicine, Division of Nephrology, University of Michigan Health System, Ann Arbor, MI, USA., Reddy P; Department of Internal Medicine, Division of Hematology and Oncology, University of Michigan, Rogel Cancer Center, Ann Arbor, MI, USA. reddypr@med.umich.edu.

Publikováno v: Nature immunology [Nat Immunol] 2021 Nov; Vol. 22 (11), pp. 1440-1451. Date of Electronic Publication: 2021 Oct 22.

What Binds Cationic Photosensitizers Better: Brownian Dynamics Reveals Key Interaction Sites on Spike Proteins of SARS-CoV, MERS-CoV, and SARS-CoV-2.

Autor: Fedorov V; Faculty of Biology, Lomonosov Moscow State University, 119234 Moscow, Russia., Kholina E; Faculty of Biology, Lomonosov Moscow State University, 119234 Moscow, Russia., Khruschev S; Faculty of Biology, Lomonosov Moscow State University, 119234 Moscow, Russia., Kovalenko I; Faculty of Biology, Lomonosov Moscow State University, 119234 Moscow, Russia.; Federal Scientific and Clinical Center of Specialized Types of Medical Care and Medical Technologies of the Federal Medical and Biological Agency of Russia, 115682 Moscow, Russia.; Institute for Persolanized Medicine, Sechenov First Moscow State Medical University (Sechenov University), 119991 Moscow, Russia.; Institute of Physics and Mathematics, Astrakhan State University, 414056 Astrakhan, Russia.; Scientific and Technological Center of Unique Instrumentation of the Russian Academy of Sciences, 117342 Moscow, Russia.; S.M. Nikolskii Mathematical Institute, Peoples' Friendship University of Russia (RUDN University), 117198 Moscow, Russia., Rubin A; Faculty of Biology, Lomonosov Moscow State University, 119234 Moscow, Russia., Strakhovskaya M; Faculty of Biology, Lomonosov Moscow State University, 119234 Moscow, Russia.; Federal Scientific and Clinical Center of Specialized Types of Medical Care and Medical Technologies of the Federal Medical and Biological Agency of Russia, 115682 Moscow, Russia.

Publikováno v: Viruses [Viruses] 2021 Aug 15; Vol. 13 (8). Date of Electronic Publication: 2021 Aug 15.