Zobrazeno 1 - 10
of 118
pro vyhledávání: '"Ilya Gukovsky"'
Autor:
Olga A. Mareninova, Dustin L. Dillon, Carli J.M. Wightman, Iskandar Yakubov, Toshimasa Takahashi, Herbert Y. Gaisano, Keith Munson, Masaki Ohmuraya, David Dawson, Ilya Gukovsky, Anna S. Gukovskaya
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 13, Iss 2, Pp 599-622 (2022)
Background: Autophagosome, the central organelle in autophagy process, can assemble via canonical pathway mediated by LC3-II, the lipidated form of autophagy-related protein LC3/ATG8, or noncanonical pathway mediated by the small GTPase Rab9. Canonic
Externí odkaz:
https://doaj.org/article/11feff5cad444a05b90bf2cb94aaf905
Autor:
Olga A. Mareninova, Matthias Sendler, Sudarshan Ravi Malla, Iskandar Yakubov, Samuel W. French, Elmira Tokhtaeva, Olga Vagin, Viola Oorschot, Renate Lüllmann-Rauch, Judith Blanz, David Dawson, Judith Klumperman, Markus M. Lerch, Julia Mayerle, Ilya Gukovsky, Anna S. Gukovskaya
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 1, Iss 6, Pp 678-694 (2015)
Background & Aims: The pathogenic mechanism of pancreatitis is poorly understood. Recent evidence implicates defective autophagy in pancreatitis responses; however, the pathways mediating impaired autophagy in pancreas remain largely unknown. Here, w
Externí odkaz:
https://doaj.org/article/cb4a33f8eeb6420680ed96b3e0cadf95
Publikováno v:
Gastroenterology. 164:524-526
Autor:
Eszter T. Vegh, Natalia Shalbueva, Zoltán Rakonczay, Dustin L. Dillon, Nicholas O. Davidson, Stephen J. Pandol, Anna S. Gukovskaya, Olga A. Mareninova, David W. Dawson, Sudarshan R. Malla, Steven J. Bensinger, Carli J. Wightman, Toshimasa Takahashi, Yan Xie, Herbert Y. Gaisano, Samuel W. French, Fred S. Gorelick, Ilya Gukovsky
Publikováno v:
J Clin Invest
The Journal of clinical investigation, vol 131, iss 15
The Journal of clinical investigation, vol 131, iss 15
Disordered lysosomal/autophagy pathways initiate and drive pancreatitis, but the underlying mechanisms and links to disease pathology are poorly understood. Here, we show that the mannose-6-phosphate (M6P) pathway of hydrolase delivery to lysosomes c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::51296d66f09bb85e129d2fbc9e461ec8
https://europepmc.org/articles/PMC8321573/
https://europepmc.org/articles/PMC8321573/
Autor:
Olga A. Mareninova, Jerik A. Pineda, Alex G. Chang, Araz Vartoumian, Ilya Gukovsky, Anna Gukovskaya
Publikováno v:
Gastroenterology. 162:S-246
Autor:
Keith Munson, Toshimasa Takahashi, Anna S. Gukovskaya, Iskandar Yakubov, Carli J. Wightman, Ilya Gukovsky, Olga A. Mareninova, Dustin L. Dillon, David W. Dawson, Herbert Y. Gaisano, Masaki Ohmuraya
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology
Cellular and Molecular Gastroenterology and Hepatology, Vol 13, Iss 2, Pp 599-622 (2022)
Cellular and molecular gastroenterology and hepatology, vol 13, iss 2
Cellular and Molecular Gastroenterology and Hepatology, Vol 13, Iss 2, Pp 599-622 (2022)
Cellular and molecular gastroenterology and hepatology, vol 13, iss 2
Background Autophagosome, the central organelle in autophagy process, can assemble via canonical pathway mediated by LC3-II, the lipidated form of autophagy-related protein LC3/ATG8, or noncanonical pathway mediated by the small GTPase Rab9. Canonica
Autor:
Dustin L. Dillon, Anna S. Gukovskaya, Sophie Gretler, Guy E. Groblewski, Ilya Gukovsky, Wenzhuo Jia, Conner L. Holthaus, Olga A. Mareninova, Michael Pimienta, Diana D. H. Thomas
Publikováno v:
Autophagy
Pancreatitis is a common, sometimes fatal, disease of exocrine pancreas, initiated by damaged acinar cells. Recent studies implicate disordered macroautophagy/autophagy in pancreatitis pathogenesis. ATG8/LC3 protein is critical for autophagosome form
Publikováno v:
Gastroenterology. 153:1212-1226
Pancreatitis is a common disorder with significant morbidity and mortality, yet little is known about its pathogenesis, and there is no specific or effective treatment. Its development involves dysregulated autophagy and unresolved inflammation, demo
Autor:
David W. Dawson, Natalia Shalbueva, Carli J. Wightman, Olga A. Mareninova, Ilya Gukovsky, Anna S. Gukovskaya, Toshimasa Takahashi, Dustin L. Dillon, Herbert Y. Gaisano
Publikováno v:
Gastroenterology. 160:S-664
Autor:
Aurelia Lugea, Fred S. Gorelick, Guy E. Groblewski, Laura Antonucci, Richard T. Waldron, Ilya Gukovsky, Anna S. Gukovskaya, Olga A. Mareninova, Stephen J. Pandol, Michael Karin, Aida Habtezion
Publikováno v:
Pancreas, vol 48, iss 4
Acute pancreatitis (AP) is a potentially lethal inflammatory disease that lacks specific therapy. Damaged pancreatic acinar cells are believed to be the site of AP initiation. The primary function of these cells is the synthesis, storage, and export