Zobrazeno 1 - 10 of 18 pro vyhledávání: '"Ilya Gitlin"'
1
Akademický článek
Targeted Modulation of Interferon Response-Related Genes with IFN-Alpha/Lambda Inhibition
Autor: Debpali Sur, Katerina Leonova, Bar Levi, Shany Ivon Markowitz, Raichel Cohen-Harazi, Ilya Gitlin, Katerina Gurova, Andrei Gudkov, Albert Pinhasov, Igor Koman, Elimelech Nesher
Publikováno v: International Journal of Molecular Sciences, Vol 23, Iss 13, p 7248 (2022)
Interferon (IFN) signaling resulting from external or internal inflammatory processes initiates the rapid release of cytokines and chemokines to target viral or bacterial invasion, as well as cancer and other diseases. Prolonged exposure to IFNs, or
Externí odkaz: https://doaj.org/article/2f9f73aed8074b5abc734e63b59ca20d
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2
Akademický článek
TRAIN (Transcription of Repeats Activates INterferon) in response to chromatin destabilization induced by small molecules in mammalian cells
Autor: Katerina Leonova, Alfiya Safina, Elimelech Nesher, Poorva Sandlesh, Rachel Pratt, Catherine Burkhart, Brittany Lipchick, Ilya Gitlin, Costakis Frangou, Igor Koman, Jianmin Wang, Kirill Kirsanov, Marianna G Yakubovskaya, Andrei V Gudkov, Katerina Gurova
Publikováno v: eLife, Vol 7 (2018)
Cellular responses to the loss of genomic stability are well-established, while how mammalian cells respond to chromatin destabilization is largely unknown. We previously found that DNA demethylation on p53-deficient background leads to transcription
Externí odkaz: https://doaj.org/article/88616e07b80f41b895f651a4e32753ab
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3
Dormant senescence-prone cells (DSPC): a lifetime memory about systemic genotoxic stress
Autor: Katerina Leonova, Ilya Gitlin, Anatoli Gleiberman, Ilia Toshkov, Nicholas Trageser, Natalia Issaeva, Marina Antoch, Andrei Gudkov
Systemic genotoxic stress is expected to generate senescent cells and accelerate aging. Surprisingly, mice subjected to lethal dose of total body irradiation and rescued by bone marrow transplantation (TBIBMT) showed neither gain of aging-related fra
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e52cbe9a7d12c7283b84bfdbdc7e46dc
https://doi.org/10.21203/rs.3.rs-1844327/v1
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7
TRAIN (Transcription of Repeats Activates INterferon) in response to chromatin destabilization induced by small molecules in mammalian cells
Autor: Alfiya Safina, Marianna G. Yakubovskaya, Jianmin Wang, Ilya Gitlin, Elimelech Nesher, Igor Koman, Andrei V. Gudkov, Rachel Pratt, Kirill I. Kirsanov, Catherine Burkhart, Brittany C. Lipchick, Poorva Sandlesh, Katerina Gurova, Costakis Frangou, Katerina I. Leonova
Publikováno v: eLife
eLife, Vol 7 (2018)
Cellular responses to the loss of genomic stability are well-established, while how mammalian cells respond to chromatin destabilization is largely unknown. We previously found that DNA demethylation on p53-deficient background leads to transcription
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fe946c891fdde58b253061f0b576a30d
https://pubmed.ncbi.nlm.nih.gov/29400649
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8
Aging of mice is associated with p16(Ink4a)- and β-galactosidase-positive macrophage accumulation that can be induced in young mice by senescent cells
Autor: Vitaly Balan, Peter Krasnov, Brandon M. Hall, Katerina I. Leonova, Evguenia Strom, Karina Balan, Olga B. Chernova, Ilya Gitlin, Slavoljub Vujcic, Andrei V. Gudkov, Lauren P. Virtuoso, Anatoli S. Gleiberman, Elena Rydkina, Alexander Polinsky
Publikováno v: Aging (Albany NY)
Senescent cells (SCs) have been considered a source of age-related chronic sterile systemic inflammation and a target for anti-aging therapies. To understand mechanisms controlling the amount of SCs, we analyzed the phenomenon of rapid clearance of h
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c452b3e3cc4b4e2193bba213773cc838
https://pubmed.ncbi.nlm.nih.gov/28783709
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9
A In Vitro and In Vivo Study of the Ability of NOD1 Ligands to Activate the Transcriptional Factor NF-kB
Autor: Denis Y. Logunov, Alexander L. Gintsburg, A. I. Tukhvatulin, P V Kudan, M M Shmarov, N N Kostyukova, A A Adzhieva, Boris S. Naroditsky, A F Moroz, Lyudmila G. Burdelya, Ilya Gitlin, Andrei V. Gudkov
Publikováno v: Acta Naturae. 3:77-84
Pattern-recognition receptors (PRR) play a crucial role in the induction of the defense reactions of the immune system against pathogenic bacterial and viral infections. The activation of PRR by specific, highly conserved pathogen-associated molecula
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::32e8197f9ebe6fb8ac134fd56722aaf1
https://doi.org/10.32607/20758251-2011-3-1-77-84
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10
Abstract 2866: Anticancer effect of a new cyclic peptide ALOS4 is associated with its systemic anti-inflammatory activity
Autor: Shiri Yakobovich, Oryan Agranyoni, Michael Kirby, Andrei V. Gudkov, Shany I. Elbaz, Olga Udartseva, Bar Shoval, Maria Becker, Raichel Cohen Harazi, Elimelech Nesher, Ilya Gitlin, Katerina I. Leonova, Albert Pinhasov, Igor Koman, Katerina Gurova
Publikováno v: Cancer Research. 78:2866-2866
The association of chronic inflammation with cancer development and progression has been well recognized. Here, we report a synthetic cyclic peptide, ALOS4, capable of suppressing tumor growth following systemic administration and possessing anti-inf
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::fddea3740ea0d6cf4a79678cca7ba630
https://doi.org/10.1158/1538-7445.am2018-2866
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