Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Ilya G. Lyakhov"'
Autor:
Rafal Zielinski, Amir H. Gandjbakhche, Kimberly Shafer-Weaver, Monika Kuban, Jacek Capala, Moinuddin Hassan, Ilya G. Lyakhov
Publikováno v:
Clinical Cancer Research. 17:5071-5081
Purpose: Cancers overexpressing the HER2/neu gene are usually more aggressive and are associated with poor prognosis. Although trastuzumab has significantly improved the outcome, many tumors do not respond or acquire resistance to current therapies.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::33a3413573f5f2f5bdbabf51371f52cf
https://doi.org/10.1158/1078-0432.ccr-10-2887
https://doi.org/10.1158/1078-0432.ccr-10-2887
Autor:
Ilya G. Lyakhov, Jacek Capala, Brandon T. Smith, Anu Puri, Kristin H. Loomis, Danielle Needle, Ulrich Baxa, Amichai Yavlovich, Robert Blumenthal
Publikováno v:
Journal of Controlled Release. 153:187-194
We previously reported the formulation and physical properties of HER2 (human epidermal growth factor receptor 2)-specific affibody (ZHER2:342-Cys) conjugated thermosensitive liposomes (HER2(+)affisomes). Here we examined localized delivery potential
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::af218bb1e78d71027371e79f04f7625f
https://doi.org/10.1016/j.jconrel.2011.04.005
https://doi.org/10.1016/j.jconrel.2011.04.005
Autor:
Rafal Zielinski, Monika Kuban, Ilya G. Lyakhov, Jacek Capala, Moinuddin Hassan, K Shafer-Weaver
Publikováno v:
Cancer Research. 70:P3-14
Introduction: Cancers overexpressing HER2 gene are usually described as more aggressive and are associated with poor prognosis. Although introduction of trastuzumab, a HER2-specific humanized antibody, significantly improved the outcome, there are st
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ce26c41435ba44573e4c464b246998d5
https://doi.org/10.1158/0008-5472.sabcs10-p3-14-23
https://doi.org/10.1158/0008-5472.sabcs10-p3-14-23
Autor:
Oleg Chertov, Gabriela Kramer-Marek, Jacek Capala, Ilya G. Lyakhov, Monika Kuban, Rafal Zielinski, Lakshman Bindu, Robert J. Fisher
Publikováno v:
ChemBioChem. 11:345-350
The human epidermal growth factor receptors, EGFR and HER2, are members of the EGFR family of cell-surface receptors/tyrosine kinases. EGFR- and HER2-positive cancers represent a more aggressive disease with greater likelihood of recurrence, poorer p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::34a1f8524dbe7d4bd54135c012d49880
https://doi.org/10.1002/cbic.200900532
https://doi.org/10.1002/cbic.200900532
Autor:
Rafal Zielinski, Gabriela Kramer-Marek, Oleg Chertov, Robert Blumenthal, Andrew G. Stephen, Ilya G. Lyakhov, Amy Jacobs, Jacek Capala, Robert J. Fisher, Nicholas Francella
Publikováno v:
Journal of Immunotherapy. 32:817-825
Expression of the human epidermal growth factor receptor 2 (HER2) is amplified in 25 – 30% of breast cancers and has been associated with an unfavorable prognosis. Here we report the construction, purification, and characterization of Affitoxin –
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c2b68c2da1167221d1d6571551b0315
https://doi.org/10.1097/cji.0b013e3181ad4d5d
https://doi.org/10.1097/cji.0b013e3181ad4d5d
Autor:
Zehua Chen, Ilya G. Lyakhov, Ryan K. Shultzaberger, Karen A. Lewis, Ming Zheng, Bernard Doan, Gisela Storz, Thomas D. Schneider
Publikováno v:
Nucleic Acids Research
Fur is a DNA binding protein that represses bacterial iron uptake systems. Eleven footprinted Escherichia coli Fur binding sites were used to create an initial information theory model of Fur binding, which was then refined by adding 13 experimentall
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bfc1429e21b2d0be36b6e9f4a7ce02ce
https://doi.org/10.1093/nar/gkm631
https://doi.org/10.1093/nar/gkm631
Autor:
Robert J. Fisher, Ilya G. Lyakhov, Igor A. Sidorov, Ryan K. Shultzaberger, Thomas D. Schneider, Lindsey R. Roberts, Andrew G. Stephen
Publikováno v:
Nucleic Acids Research
Individual protein binding sites on DNA can be measured in bits of information. This information is related to the free energy of binding by the second law of thermodynamics, but binding kinetics appear to be inaccessible from sequence information si
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6bf8c8adb464fba2d3f5b443d88cd2b5
https://doi.org/10.1093/nar/gkm471
https://doi.org/10.1093/nar/gkm471
Publikováno v:
Nucleic Acids Research. 31:6663-6673
The DNA-binding protein Fis frequently uses pairs of sites 7 or 11 base pairs (bp) apart. Two overlapping Fis sites separated by 11 bp are found in the Escherichia coli origin of chromosomal replication. Only one of these sites is bound by Fis at a t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3532bc222f18044b72df7856a90ffc22
https://doi.org/10.1093/nar/gkg877
https://doi.org/10.1093/nar/gkg877
Publikováno v:
Methods in Molecular Biology ISBN: 9781493916603
Computed Tomography (CT), Ultrasound (US), and Magnetic Resonance Imaging (MRI) have been the mainstay of clinical imaging regimens for the detection of ovarian cancer. However, without tumor specific contrast enhancement, these imaging modalities la
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e92aa5c16693ca650aea722e8ec37291
https://doi.org/10.1007/978-1-4939-1661-0_13
https://doi.org/10.1007/978-1-4939-1661-0_13
Autor:
Ilya G. Lyakhov, Sergei A. Nedospasov, Anatoly V. Rubtsov, Michael W. Marino, Alexei V. Tumanov, Ludmila N. Drutskaya, Shakhov An
Publikováno v:
Journal of Leukocyte Biology. 68:151-157
Mice with combined lymphotoxin-α (LTα) and tumor necrosis factor (TNF) deficiencies show defects in the structure of peripheral lymphoid organs such as spleen, lymph nodes, and gut-associated lymphoid tissues. To identify genes associated with this
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f91d6478dfcf436260951e6116e5e14e
https://doi.org/10.1189/jlb.68.1.151
https://doi.org/10.1189/jlb.68.1.151