Neuroprotective Properties of Quinone Reductase 2 Inhibitor M-11, a 2-Mercaptobenzimidazole Derivative

Autor: Mikhail V. Voronin, Ilya A. Kadnikov, Liana F. Zainullina, Ilya O. Logvinov, Ekaterina R. Verbovaya, Tatyana A. Antipova, Yulia V. Vakhitova, Sergei B. Seredenin

Publikováno v: International Journal of Molecular Sciences, Vol 22, Iss 13061, p 13061 (2021)
International Journal of Molecular Sciences; Volume 22; Issue 23; Pages: 13061
International Journal of Molecular Sciences

The ability of NQO2 to increase the production of free radicals under enhanced generation of quinone derivatives of catecholamines is considered to be a component of neurodegenerative disease pathogenesis. The present study aimed to investigate the n

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::37e78edbc8e73beccc109de7c97492e4
https://www.mdpi.com/1422-0067/22/23/13061

Analysis of Antidepressant-like Effects and Action Mechanisms of GSB-106, a Small Molecule, Affecting the TrkB Signaling

Autor: Yulia V. Vakhitova, Tatiana S. Kalinina, Liana F. Zainullina, Anastasiya Yu. Lusta, Anna V. Volkova, Nikita V. Kudryashov, Tatiana A. Gudasheva, Alexander A. Shimshirt, Ilya A. Kadnikov, Mikhail V. Voronin, Sergei B. Seredenin

Publikováno v: International Journal of Molecular Sciences, Vol 22, Iss 13381, p 13381 (2021)
International Journal of Molecular Sciences; Volume 22; Issue 24; Pages: 13381
International Journal of Molecular Sciences

Induction of BDNF-TrkB signaling is associated with the action mechanisms of conventional and fast-acting antidepressants. GSB-106, developed as a small dimeric dipeptide mimetic of BDNF, was previously shown to produce antidepressant-like effects in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f7ef8b45af426ca291bee7f78675dd4e
https://doi.org/10.3390/ijms222413381

Deferred Administration of Afobazole Induces Sigma1R-Dependent Restoration of Striatal Dopamine Content in a Mouse Model of Parkinson’s Disease

Autor: Dmitry N. Voronkov, Ekaterina R Verbovaya, Ilya A. Kadnikov, Sergei B Seredenin, Mikhail V. Voronin

Publikováno v: International Journal of Molecular Sciences
Volume 21
Issue 20
International Journal of Molecular Sciences, Vol 21, Iss 7620, p 7620 (2020)

Previously, we demonstrated that the immediate administration of multitarget anxiolytic afobazole slows down the progression of neuronal damage in a 6-hydroxidodamine (6-OHDA) model of Parkinson&rsquo
s disease due to the activation of chaperone

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::af68cfc019d1afc46a069123c699717f
https://doi.org/10.3390/ijms21207620