Zobrazeno 1 - 10
of 49
pro vyhledávání: '"Ilse van den Wyngaert"'
Autor:
Lina Vandermeulen, Ivana Geric, Laura Fumagalli, Mohamed Kreir, Ashley Lu, Annelies Nonneman, Jessie Premereur, Leen Wolfs, Rafaela Policarpo, Nicola Fattorelli, An De Bondt, Ilse Van Den Wyngaert, Bob Asselbergh, Mark Fiers, Bart De Strooper, Constantin d’Ydewalle, Renzo Mancuso
Publikováno v:
Molecular Neurodegeneration, Vol 19, Iss 1, Pp 1-25 (2024)
Abstract Background Microglia play important roles in maintaining brain homeostasis and neurodegeneration. The discovery of genetic variants in genes predominately or exclusively expressed in myeloid cells, such as Apolipoprotein E (APOE) and trigger
Externí odkaz:
https://doaj.org/article/5e41afed90e54039b14a1ba9aaa0716d
Autor:
Argyro Thalia Delizannis, Annelies Nonneman, Wangchen Tsering, An De Bondt, Ilse Van den Wyngaert, Bin Zhang, Emily Meymand, Modupe F. Olufemi, Pyry Koivula, Shaniya Maimaiti, John Q. Trojanowski, Virginia M.-Y. Lee, Kurt R. Brunden
Publikováno v:
Acta Neuropathologica Communications, Vol 9, Iss 1, Pp 1-19 (2021)
Abstract Dystrophic neuronal processes harboring neuritic plaque (NP) tau pathology are found in association with Aβ plaques in Alzheimer’s disease (AD) brain. Microglia are also in proximity to these plaques and microglial gene variants are known
Externí odkaz:
https://doaj.org/article/38ca6ff95cd948748669efa9344b7086
Autor:
An Verheyen, Annick Diels, Joke Reumers, Kirsten Van Hoorde, Ilse Van den Wyngaert, Constantin van Outryve d’Ydewalle, An De Bondt, Jacobine Kuijlaars, Louis De Muynck, Ronald De Hoogt, Alexis Bretteville, Steffen Jaensch, Arjan Buist, Alfredo Cabrera-Socorro, Selina Wray, Andreas Ebneth, Peter Roevens, Ines Royaux, Pieter J. Peeters
Publikováno v:
Stem Cell Reports, Vol 11, Iss 2, Pp 363-379 (2018)
Summary: Tauopathies such as frontotemporal dementia (FTD) remain incurable to date, partially due to the lack of translational in vitro disease models. The MAPT gene, encoding the microtubule-associated protein tau, has been shown to play an importa
Externí odkaz:
https://doaj.org/article/301136220c5f4b20bc2ad49e591d873f
Autor:
Fanny Knöspel, Frank Jacobs, Nora Freyer, Georg Damm, An De Bondt, Ilse van den Wyngaert, Jan Snoeys, Mario Monshouwer, Marco Richter, Nadja Strahl, Daniel Seehofer, Katrin Zeilinger
Publikováno v:
International Journal of Molecular Sciences, Vol 17, Iss 4, p 584 (2016)
Accurate prediction of the potential hepatotoxic nature of new pharmaceuticals remains highly challenging. Therefore, novel in vitro models with improved external validity are needed to investigate hepatic metabolism and timely identify any toxicity
Externí odkaz:
https://doaj.org/article/fe8987039a4a4493a111bc7c484d306d
Autor:
Katleen De Preter, Frank Speleman, Jorge Vialard, Johannes H. Schulte, Jan Cools, Piotr Zabrocki, Tom Van Maerken, Alan Van Goethem, Nadine Van Roy, Ilse Van Den Wyngaert, David Camacho Trujillo, Junko Takita, Michael Porcu, Glenn M. Marchall, Chris Liang, Geneviève Laureys, Isabelle Janoueix-Lerosey, Jay Gibbons, Olivier Delattre, Sara De Brouwer, An De Bondt, Marilena De Mariano, Belamy B. Cheung, Alex Cazes, Daniel R. Carter, Els Janssens, Anneleen Beckers, Sven Lindner, Shana Claeys, Candy Kumps, Irina Lambertz
Supplemental data 9: Summary of Gene Set Enrichment analysis results performed on expression data upon ALK inhibition in 10 cell lines
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f8ba2b9fbd5cfbaa48dbc06a331da43
https://doi.org/10.1158/1078-0432.22459751.v1
https://doi.org/10.1158/1078-0432.22459751.v1
Autor:
Katleen De Preter, Frank Speleman, Jorge Vialard, Johannes H. Schulte, Jan Cools, Piotr Zabrocki, Tom Van Maerken, Alan Van Goethem, Nadine Van Roy, Ilse Van Den Wyngaert, David Camacho Trujillo, Junko Takita, Michael Porcu, Glenn M. Marchall, Chris Liang, Geneviève Laureys, Isabelle Janoueix-Lerosey, Jay Gibbons, Olivier Delattre, Sara De Brouwer, An De Bondt, Marilena De Mariano, Belamy B. Cheung, Alex Cazes, Daniel R. Carter, Els Janssens, Anneleen Beckers, Sven Lindner, Shana Claeys, Candy Kumps, Irina Lambertz
Supplemental data 13: Summary of Gene Set Enrichment analysis results obtained on expression profiling data of CLB-Ââ€�GA on different time points (10' - 30'- 60' - 2h - 4h - 6h) after pharmacological inhibition using TAE-Ââ€�684.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::25178759ac101de20553303d661c8c67
https://doi.org/10.1158/1078-0432.22459757.v1
https://doi.org/10.1158/1078-0432.22459757.v1
Autor:
Katleen De Preter, Frank Speleman, Jorge Vialard, Johannes H. Schulte, Jan Cools, Piotr Zabrocki, Tom Van Maerken, Alan Van Goethem, Nadine Van Roy, Ilse Van Den Wyngaert, David Camacho Trujillo, Junko Takita, Michael Porcu, Glenn M. Marchall, Chris Liang, Geneviève Laureys, Isabelle Janoueix-Lerosey, Jay Gibbons, Olivier Delattre, Sara De Brouwer, An De Bondt, Marilena De Mariano, Belamy B. Cheung, Alex Cazes, Daniel R. Carter, Els Janssens, Anneleen Beckers, Sven Lindner, Shana Claeys, Candy Kumps, Irina Lambertz
Supplemental data 1: Cell line information: Summary of the characteristics of cell lines used in this study including origin, tumor type, ALK and MYCN status (wt = wild type, NA = non amplified, A = amplified). Supplemental data 2: GI50 concentration
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f3d207cd2c5d9d3ddc79d0dc2c9a918
https://doi.org/10.1158/1078-0432.22459748
https://doi.org/10.1158/1078-0432.22459748
Autor:
Katleen De Preter, Frank Speleman, Jorge Vialard, Johannes H. Schulte, Jan Cools, Piotr Zabrocki, Tom Van Maerken, Alan Van Goethem, Nadine Van Roy, Ilse Van Den Wyngaert, David Camacho Trujillo, Junko Takita, Michael Porcu, Glenn M. Marchall, Chris Liang, Geneviève Laureys, Isabelle Janoueix-Lerosey, Jay Gibbons, Olivier Delattre, Sara De Brouwer, An De Bondt, Marilena De Mariano, Belamy B. Cheung, Alex Cazes, Daniel R. Carter, Els Janssens, Anneleen Beckers, Sven Lindner, Shana Claeys, Candy Kumps, Irina Lambertz
Supplemental data 5: Differential expression analysis upon ALK inhibition
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::259ac911c3c0e63378435357663b5dc6
https://doi.org/10.1158/1078-0432.22459754.v1
https://doi.org/10.1158/1078-0432.22459754.v1
Autor:
Katleen De Preter, Frank Speleman, Jorge Vialard, Johannes H. Schulte, Jan Cools, Piotr Zabrocki, Tom Van Maerken, Alan Van Goethem, Nadine Van Roy, Ilse Van Den Wyngaert, David Camacho Trujillo, Junko Takita, Michael Porcu, Glenn M. Marchall, Chris Liang, Geneviève Laureys, Isabelle Janoueix-Lerosey, Jay Gibbons, Olivier Delattre, Sara De Brouwer, An De Bondt, Marilena De Mariano, Belamy B. Cheung, Alex Cazes, Daniel R. Carter, Els Janssens, Anneleen Beckers, Sven Lindner, Shana Claeys, Candy Kumps, Irina Lambertz
Purpose: Activating ALK mutations are present in almost 10% of primary neuroblastomas and mark patients for treatment with small-molecule ALK inhibitors in clinical trials. However, recent studies have shown that multiple mechanisms drive resistance
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::76e9c231d90692706480e995eac2927b
https://doi.org/10.1158/1078-0432.c.6524297
https://doi.org/10.1158/1078-0432.c.6524297
Autor:
Ellen Van Gulck, Marion Pardons, Erik Nijs, Nick Verheyen, Koen Dockx, Christel Van den Eynde, Emilie Battivelli, Jerel Vega, Eric Florence, Brigitte Autran, Nancie M. Archin, David M. Margolis, Kristine Katlama, Chiraz Hamimi, Ilse Van den Wyngaert, Filmon Eyassu, Linos Vandekerckhove, Daniel Boden
A major barrier to HIV-1 cure is caused by the pool of latently infected CD4 T-cells that persist under combination antiretroviral therapy (cART). This latent reservoir is capable of producing replication-competent infectious virus once prolonged sup
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c4e27f9bd942c8cab7e5f7e17773de3c
https://doi.org/10.1101/2023.03.02.530914
https://doi.org/10.1101/2023.03.02.530914