Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Ilse R. Dubbelboer"'
Gastrointestinal mucus in dog: Physiological characteristics, composition, and structural properties
Autor:
Ilse R. Dubbelboer, Vicky Barmpatsalou, Agnes Rodler, Eva Karlsson, Sandro Filipe Nunes, Johanna Holmberg, Jens Häggström, Christel A.S. Bergström
Publikováno v:
European Journal of Pharmaceutics and Biopharmaceutics. 173:92-102
Gastrointestinal (GI) mucus is continuously secreted and lines the entire length of the GI tract. Essential for health, it keeps the noxious luminal content away from the epithelium. Our aim was to characterize the composition and structure of mucus
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0082a5437b593bd49af3dd684b105f26
https://doi.org/10.1016/j.ejpb.2022.02.019
https://doi.org/10.1016/j.ejpb.2022.02.019
Autor:
Ilse R. Dubbelboer, Erik Sjögren
Publikováno v:
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences. 173
There is a growing body of research about subcutaneously administered biologics, emphasizing the need for optimized bioavailability predictions. It is important to inform both translational and in silico models with properties of the drug products an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::69b0d19c4cfa9407aa1e1e4682473aa7
https://pubmed.ncbi.nlm.nih.gov/35381330
https://pubmed.ncbi.nlm.nih.gov/35381330
Autor:
Ilse R. Dubbelboer, Erik Sjögren
Publikováno v:
International Journal of Pharmaceutics. 621:121808
Subcutaneous injection is a commonly used route of drug administration for both small molecules and biologics. To facilitate the development of new subcutaneously administered drugs, methods for prediction of drug absorption from the injection site a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7249ae20d9a03d6a09bf2bf84e7e2323
https://doi.org/10.1016/j.ijpharm.2022.121808
https://doi.org/10.1016/j.ijpharm.2022.121808
Autor:
Betty Lomstein Pedersen, Magdalena Jacobson, Eva Karlsson, Ilse R. Dubbelboer, Agnes Rodler, Vicky Barmpatsalou, Christel Ann Sofie Bergström
The gastrointestinal mucus is a hydrogel that lines the luminal side of the gastrointestinal epithelium, offering barrier protection from pathogens and lubrication of the intraluminal contents. These barrier properties likewise affect nutrients and d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4fbd2b8eea610b622b1fe4753a9d91b6
http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-459781
http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-459781
Autor:
Charlotte Ebeling Barbier, Ulf Bondesson, Rickard Nyman, Frans Duraj, Torkel B. Brismar, Hans Lennernäs, Agneta Norén, Rimma Axelsson, Elsa Lilienberg, Per Stål, Ilse R. Dubbelboer, Erik Sjögren, Amar Karalli, Mikael Hedeland
Publikováno v:
Molecular Pharmaceutics. 15:336-340
Reply to "Comment on 'In Vivo Drug Delivery Performance of Lipiodol-Based Emulsion or Drug-Eluting Beads in Patients with Hepatocellular Carcinoma'"
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7945ea239467bad00f7f373a1749ea6b
https://doi.org/10.1021/acs.molpharmaceut.7b00840
https://doi.org/10.1021/acs.molpharmaceut.7b00840
Publikováno v:
Cancers
Cancers, Vol 11, Iss 7, p 1024 (2019)
Volume 11
Issue 7
Cancers, Vol 11, Iss 7, p 1024 (2019)
Volume 11
Issue 7
Hepatocellular carcinoma is often treated with a combination of doxorubicin and embolization, exposing it to high concentrations and hypoxia. Separation of the possible synergistic effect of this combination in vivo is difficult. Here, treatment with
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fcbed38cc0b9dce0d6d8315f40c38ebd
https://pubmed.ncbi.nlm.nih.gov/31330834
https://pubmed.ncbi.nlm.nih.gov/31330834
Publikováno v:
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V. 142
Intestinal permeability is a key biopharmaceutical variable in pharmaceutical research and development, and regulatory assessment. In situ rat models are often used to predict the corresponding human intestinal permeability data. The rat single-pass
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::41e0c09f89466017d35469baa9b77d72
https://pubmed.ncbi.nlm.nih.gov/31283980
https://pubmed.ncbi.nlm.nih.gov/31283980
Publikováno v:
Journal of Pharmacy and Pharmacology. 69:135-142
Objectives In liver cancer treatment, lipiodol is used as a pharmaceutical excipient to improve delivery of the cytostatic drug doxorubicin (DOX). As DOX and its metabolite doxorubicinol (DOXol) cause serious off-target adverse effects, we investigat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::75fcb86d3c5c989b07aa4cfdd50ddb2f
https://doi.org/10.1111/jphp.12665
https://doi.org/10.1111/jphp.12665
Publikováno v:
The AAPS journal. 20(6)
It is important to be able to simulate and predict formulation effects on the pharmacokinetics of a drug in order to optimize effectivity in clinical practice and drug development. Two formulations containing doxorubicin are used in the treatment of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f8cc6ad8ffc20b6dba3c833324c49b4
https://pubmed.ncbi.nlm.nih.gov/30167825
https://pubmed.ncbi.nlm.nih.gov/30167825
Publikováno v:
Molecular pharmaceutics. 14(3)
Doxorubicin is an anticancer agent, which binds reversibly to topoisomerase I and II, intercalates to DNA base pairs, and generates free radicals. Doxorubicin has a high tissue:plasma partition coefficient and high intracellular binding to the nucleu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::26e00afd8df3885d2f0d0f2f64f412d4
https://pubmed.ncbi.nlm.nih.gov/28182434
https://pubmed.ncbi.nlm.nih.gov/28182434