Zobrazeno 1 - 10
of 37
pro vyhledávání: '"Ilse M Beck"'
Autor:
Dorien Clarisse, Karlien Van Wesemael, Jan Tavernier, Fritz Offner, Ilse M Beck, Karolien De Bosscher
Publikováno v:
PLoS ONE, Vol 13, Iss 5, p e0197000 (2018)
Glucocorticoids (GCs) are a cornerstone in the treatment of lymphoid malignancies such as multiple myeloma (MM) and acute lymphoblastic leukemia (ALL). Yet, prolonged GC use is hampered by deleterious GC-related side effects and the emergence of GC r
Externí odkaz:
https://doaj.org/article/324635f5e56c4638ba365ff33716d759
Autor:
Ilse M Beck, Koen Van Crombruggen, Gabriele Holtappels, François Daubeuf, Nelly Frossard, Claus Bachert, Karolien De Bosscher
Publikováno v:
PLoS ONE, Vol 10, Iss 4, p e0123068 (2015)
BACKGROUND:Glucocorticoid Receptor agonists, particularly classic glucocorticoids, are the mainstay among treatment protocols for various chronic inflammatory disorders, including nasal disease. To steer away from steroid-induced side effects, novel
Externí odkaz:
https://doaj.org/article/724fcfb63e25415990de787bf7b23af8
Autor:
Katarzyna Szarc vel Szic, Ken Op de Beeck, Dariusz Ratman, An Wouters, Ilse M Beck, Ken Declerck, Karen Heyninck, Erik Fransen, Marc Bracke, Karolien De Bosscher, Filip Lardon, Guy Van Camp, Wim Vanden Berghe
Publikováno v:
PLoS ONE, Vol 9, Iss 2, p e87850 (2014)
Withaferin A (WA) isolated from Withania somnifera (Ashwagandha) has recently become an attractive phytochemical under investigation in various preclinical studies for treatment of different cancer types. In the present study, a comparative pathway-b
Externí odkaz:
https://doaj.org/article/606a1d5280a2482984e244e0f871c4dd
Autor:
Ilse M Beck, Zuzanna J Drebert, Ruben Hoya-Arias, Ali A Bahar, Michael Devos, Dorien Clarisse, Sofie Desmet, Nadia Bougarne, Bart Ruttens, Valerie Gossye, Geertrui Denecker, Sam Lievens, Marc Bracke, Jan Tavernier, Wim Declercq, Kris Gevaert, Wim Vanden Berghe, Guy Haegeman, Karolien De Bosscher
Publikováno v:
PLoS ONE, Vol 8, Iss 7, p e69115 (2013)
Compound A possesses glucocorticoid receptor (GR)-dependent anti-inflammatory properties. Just like classical GR ligands, Compound A can repress NF-κB-mediated gene expression. However, the monomeric Compound A-activated GR is unable to trigger gluc
Externí odkaz:
https://doaj.org/article/e7db32ca698446dba6bb65b1baa9d22c
Autor:
Dorien Clarisse, Stefan Prekovic, Philip Vlummens, Eleni Staessens, Karlien Van Wesemael, Jonathan Thommis, Daria Fijalkowska, Guillaume Acke, Wilbert Zwart, Ilse M. Beck, Fritz Offner, Karolien De Bosscher
The glucocorticoid receptor (GR) is a crucial drug target in multiple myeloma as its activation with glucocorticoids effectively triggers myeloma cell death. However, as high-dose glucocorticoids are also associated with deleterious side effects, nov
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::947d572d4c5fd526a7f622a489626dac
https://doi.org/10.1101/2023.05.10.540157
https://doi.org/10.1101/2023.05.10.540157
Autor:
Elly De Vlieghere, Karolien De Bosscher, Olivier De Wever, Ilse M. Beck, Jolien Bridelance, Zuzanna Drebert, Marc Bracke
Publikováno v:
Experimental Cell Research. 362:332-342
Cancer-associated fibroblasts (CAFs) support cancer growth, invasion, and metastasis. Glucocorticoids (GCs), drugs often administered together with chemotherapy, are steroidal ligands of the glucocorticoid receptor (GR), a transcription factor which
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::af6183f566a0d687438e53bd46be210d
https://doi.org/10.1016/j.yexcr.2017.11.034
https://doi.org/10.1016/j.yexcr.2017.11.034
Autor:
Nadia Bougarne, Viacheslav Mylka, Dariusz Ratman, Ilse M. Beck, Jonathan Thommis, Lode De Cauwer, Jan Tavernier, Bart Staels, Claude Libert, Karolien De Bosscher
Publikováno v:
Frontiers in Immunology
FRONTIERS IN IMMUNOLOGY
Frontiers in Immunology, Vol 10 (2019)
FRONTIERS IN IMMUNOLOGY
Frontiers in Immunology, Vol 10 (2019)
Glucocorticoids (GCs) act via the glucocorticoid receptor (NR3C1, GR alpha) to combat overshooting responses to infectious stimuli, including lipopolysaccharide (LPS). As such, GCs inhibit the activity of downstream effector cytokines, such as tumor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::44f0adff9c849331b54dbbe6acb99518
https://pubmed.ncbi.nlm.nih.gov/31447832
https://pubmed.ncbi.nlm.nih.gov/31447832
Autor:
Emmanuel Van Acker, Karel A.C. De Schamphelaere, Ilse M. Beck, Lynn Vanhaecke, Colin R. Janssen, Jana Asselman, Maarten De Rijcke, Steve Huysman
Publikováno v:
Marine Drugs
Volume 18
Issue 1
MARINE DRUGS
Marine Drugs, Vol 18, Iss 1, p 46 (2020)
Volume 18
Issue 1
MARINE DRUGS
Marine Drugs, Vol 18, Iss 1, p 46 (2020)
Respiratory exposure to marine phycotoxins is of increasing concern. Inhalation of sea spray aerosols (SSAs), during harmful Karenia brevis and Ostreopsis ovata blooms induces respiratory distress among others. The biogenics hypothesis, however, sugg
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a34d2b3ef5a9c6d077011b61c2a26e5
https://doi.org/10.3390/md18010046
https://doi.org/10.3390/md18010046
Autor:
Jan Tavernier, Dorien Clarisse, Karlien Van Wesemael, Ilse M. Beck, Fritz Offner, Karolien De Bosscher
Publikováno v:
PLoS ONE
PLoS ONE, Vol 13, Iss 5, p e0197000 (2018)
PLOS ONE
PLoS ONE, Vol 13, Iss 5, p e0197000 (2018)
PLOS ONE
Glucocorticoids (GCs) are a cornerstone in the treatment of lymphoid malignancies such as multiple myeloma (MM) and acute lymphoblastic leukemia (ALL). Yet, prolonged GC use is hampered by deleterious GC-related side effects and the emergence of GC r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::253df2c87295eb54a49343bd14df8310
https://pubmed.ncbi.nlm.nih.gov/29738549
https://pubmed.ncbi.nlm.nih.gov/29738549
Publikováno v:
PHARMACOLOGY & THERAPEUTICS
Glucocorticoids remain the frontline treatment for inflammatory disorders, yet represent a double-edged sword with beneficial therapeutic actions alongside adverse effects, mainly in metabolic regulation. Considerable efforts were made to improve thi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed43cd6e882a1a8edf1616f0868e38e2