Chorioamnionitis induces hepatic inflammation and time-dependent changes of the enterohepatic circulation in the ovine fetus

Autor: Cathelijne Heymans, Marcel den Dulk, Kaatje Lenaerts, Lara R. Heij, Ilse H. de Lange, Mhamed Hadfoune, Chantal van Heugten, Boris W. Kramer, Alan H. Jobe, Masatoshi Saito, Matthew W. Kemp, Tim G. A. M. Wolfs, Wim G. van Gemert

Publikováno v: Scientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)

Abstract Chorioamnionitis, inflammation of fetal membranes, is an important cause of preterm birth and a risk factor for the development of adverse neonatal outcomes including sepsis and intestinal pathologies. Intestinal bile acids (BAs) accumulatio

Externí odkaz: https://doaj.org/article/273428c886924b54a836d79f2671ccd5

Chronic Intra-Uterine Ureaplasma parvum Infection Induces Injury of the Enteric Nervous System in Ovine Fetuses

Autor: Cathelijne Heymans, Ilse H. de Lange, Matthias C. Hütten, Kaatje Lenaerts, Nadine J. E. de Ruijter, Lilian C. G. A. Kessels, Glenn Rademakers, Veerle Melotte, Werend Boesmans, Masatoshi Saito, Haruo Usuda, Sarah J. Stock, Owen B. Spiller, Michael L. Beeton, Matthew S. Payne, Boris W. Kramer, John P. Newnham, Alan H. Jobe, Matthew W. Kemp, Wim G. van Gemert, Tim G. A. M. Wolfs

Publikováno v: Frontiers in Immunology, Vol 11 (2020)

Background: Chorioamnionitis, inflammation of the fetal membranes during pregnancy, is often caused by intra-amniotic (IA) infection with single or multiple microbes. Chorioamnionitis can be either acute or chronic and is associated with adverse post

Externí odkaz: https://doaj.org/article/8e84c3d69950436eacde54ffc5d35f08

Antenatal Ureaplasma infection induces ovine small intestinal goblet cell defects

Autor: Charlotte van Gorp, Ilse H de Lange, Matthias C Hütten, Carmen López-Iglesias, Kimberly RI Massy, Lilian Kessels, Boris Kramer, Willine van de Wetering, Brad Spiller, George M Birchenough, Wim G van Gemert, Luc J Zimmermann, Tim GAM Wolfs

Publikováno v: Tissue Barriers. Routledge/Taylor & Francis Group

Disruption of the intestinal mucus barrier and intestinal epithelial endoplasmic reticulum (ER) stress contribute to necrotizing enterocolitis (NEC). Previously, we observed intestinal goblet cell loss and increased intestinal epithelial ER stress fo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9710d76eb8b32d745d55868ec0d963d3
https://cris.maastrichtuniversity.nl/en/publications/dc5dfde5-3c31-42ac-a4b1-ef8268f3e2cc

Protection of the ovine fetal gut against ureaplasma-induced chorioamnionitis: a potential role for plant sterols

Autor: Boris W. Kramer, Jogchum Plat, Matthew W. Kemp, Ron M. A. Heeren, Charlotte van Gorp, Wim G. van Gemert, Sarah J. Stock, Matthew S. Payne, Frédéric Dewez, Michael L. Beeton, Nico Kloosterboer, Berta Cillero Pastor, Alan H. Jobe, Lilian Kessels, Luc J. I. Zimmermann, Tim G. A. M. Wolfs, Owen B. Spiller, Ilse H. de Lange

Publikováno v: Nutrients
van Gorp, C, de Lange, I H, Spiller, O B, Dewez, F, Cillero Pastor, B, Heeren, R M A, Kessels, L, Kloosterboer, N, van Gemert, W G, Beeton, M L, Stock, S J, Jobe, A H, Payne, M S, Kemp, M W, Zimmermann, L J, Kramer, B W, Plat, J & Wolfs, T G A M 2019, ' Protection of the Ovine Fetal Gut against Ureaplasma-Induced Chorioamnionitis : A Potential Role for Plant Sterols ', Nutrients, vol. 11, no. 5 . https://doi.org/10.3390/nu11050968
Nutrients, 11(5):968, 1-21. Multidisciplinary Digital Publishing Institute (MDPI)
Volume 11
Issue 5
Nutrients, Vol 11, Iss 5, p 968 (2019)

Chorioamnionitis, clinically most frequently associated with Ureaplasma, is linked to intestinal inflammation and subsequent gut injury. No treatment is available to prevent chorioamnionitis-driven adverse intestinal outcomes. Evidence is increasing

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::be1268294232f335355ea6c189b718b9
https://orca.cardiff.ac.uk/id/eprint/122002/1/nutrients-11-00968.pdf

Parry Romberg syndrome presenting with a giant intracranial aneurysm: a case report

Autor: Levinus A. Bok, F. J. J. Halbertsma, Anna Mt van Oploo, F George Roos, Ilse H. de Lange

Publikováno v: Oxford Medical Case Reports

A giant intracranial aneurysm was diagnosed in a 10-year-old girl when she developed a right abducens nerve palsy. The aneurysm was treated successfully. Six years later, however, she presented with a progressive en coup de sabre deformity, leading t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::08667a40f8dddddb142a74faf3dbb8ae
https://doi.org/10.1093/omcr/omx017