Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Ilse Goris"'
Autor:
Patrick Angibaud, Kristof van Emelen, Martin Page, Michel Janicot, Marc Du Jardin, Luc Andries, Ilse Goris, Willem Talloen, Kees Bol, Eugene Cox, Veronique Vreys, Ian Hickson, Ron Gilissen, Laurence Decrane, Bruno Roux, Isabelle Pilatte, Lut Janssen, Ann Belin, Wim Floren, Ann Marin, Peter King, Janine Arts
Purpose: Histone deacetylase (HDAC) inhibitors have shown promising clinical activity in the treatment of hematologic malignancies, but their activity in solid tumor indications has been limited. Most HDAC inhibitors in clinical development only tran
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2434ea75f5b9b9c5f4fbdf2a8833ab91
https://doi.org/10.1158/1078-0432.c.6517927
https://doi.org/10.1158/1078-0432.c.6517927
Autor:
Patrick Angibaud, Kristof van Emelen, Martin Page, Michel Janicot, Marc Du Jardin, Luc Andries, Ilse Goris, Willem Talloen, Kees Bol, Eugene Cox, Veronique Vreys, Ian Hickson, Ron Gilissen, Laurence Decrane, Bruno Roux, Isabelle Pilatte, Lut Janssen, Ann Belin, Wim Floren, Ann Marin, Peter King, Janine Arts
Supplementary Data from JNJ-26481585, a Novel Second-Generation Oral Histone Deacetylase Inhibitor, Shows Broad-Spectrum Preclinical Antitumoral Activity
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::15a60eef472554e462da36d628bd346f
https://doi.org/10.1158/1078-0432.22440625.v1
https://doi.org/10.1158/1078-0432.22440625.v1
Autor:
Elly Verbeek, Hinrich W. H. Göhlmann, Marion Crauwels, Dieder Moechars, Frans W. Verheijen, Rachel Schot, Rudi D'Hooge, Nathalie Van Acker, Stijn Stroobants, An De Bondt, Grazia M.S. Mancini, Luc Andries, Guy Daneels, Michiel W.M. Knaapen, Ilse Goris
Publikováno v:
Experimental Neurology. 291:106-119
Slc17a5(-/-) mice represent an animal model for the infantile form of sialic acid storage disease (SASD). We analyzed genetic and histological time-course expression of myelin and oligodendrocyte (OL) lineage markers in different parts of the CNS, an
Autor:
Ilse Goris, Diederik Moechars, Guy Daneels, Detlef Balschun, Sandra Leo, Nathalie Van Acker, Rudi D'Hooge, Arne Naert, Theo Meert, Zsuzsanna Callaerts-Vegh
Publikováno v:
Behavioural Brain Research. 245:13-21
The excitatory neurotransmitter l -glutamate is transported into synaptic vesicles by vesicular glutamate transporters (VGluTs) to transmit glutamatergic signals. Changes in their expression have been linked to various brain disorders including schiz
Autor:
Janine Arts, Ann Marien, Willem Talloen, Peter King, Ian Hickson, Ron Gilissen, Kristof Van Emelen, Bruno Roux, Ilse Goris, Laurence Decrane, Wim Floren, Michel Janicot, Luc Andries, Lut Janssen, Martin John Page, Ann Beliën, Eugene Cox, Veronique Vreys, Kees Bol, Patrick Angibaud, Isabelle Noëlle Constance Pilatte, Marc Du Jardin
Publikováno v:
Clinical Cancer Research. 15:6841-6851
Purpose: Histone deacetylase (HDAC) inhibitors have shown promising clinical activity in the treatment of hematologic malignancies, but their activity in solid tumor indications has been limited. Most HDAC inhibitors in clinical development only tran
Autor:
Thomas Steckler, Itzhak Levi, Yuly Bersudsky, Galila Agam, Stefan Kass, Dieder Moechars, Luc Andries, Nathalie Van Acker, Kim Cryns, J. Adriaan Bouwknecht, Haim Belmaker, Guy Daneels, Alon Shamir, Ilse Goris
Publikováno v:
Neuropsychopharmacology. 33:674-684
Lithium has been the standard pharmacological treatment for bipolar disorder over the last 50 years; however, the molecular targets through which lithium exerts its therapeutic effects are still not defined. We characterized the phenotype of mice wit
Autor:
Luc Hoskens, Guy Daneels, Dieder Moechars, Luc Ver Donck, Ilse Goris, Betty De Smet, Bernard Coulie, Inge Depoortere, Stefan Kass, Benoit Moreaux, Theo L. Peeters
Publikováno v:
Gastroenterology. 131:1131-1141
Background & Aims: The G-protein–coupled receptor GPR39 is a member of a family that includes the receptors for ghrelin and motilin. Recently the peptide obestatin was identified as a natural ligand for GPR39. The objective of this study was to gai
Autor:
Ilse Goris, Hansfried Van Craenendonck, Guy Daneels, Dieder Moechars, Ilse Lenaerts, J. Adriaan Bouwknecht, Thomas Steckler, Kim Cryns, Jos Prickaerts
Publikováno v:
Journal of Neuroscience, 26, 9022-9. Society for Neuroscience
Lithium is used as treatment for bipolar disorder with particular efficacy in the treatment of mania. Lithium inhibits glycogen synthase kinase 3 beta(GSK-3 beta) directly or indirectly via stimulation of the kinase Akt-1. We therefore investigated t
Autor:
Hansfried Van Craenendonck, Thomas Steckler, Kim Cryns, Ilse Goris, Dieder Moechars, Alon Shamir, Roel Straetemans, J. Shapiro, Galila Agam, Robert H. Belmaker, Gie Daneels
Publikováno v:
Neuropsychopharmacology. 32:881-891
Lithium is a potent mood-stabilizing medication in bipolar disorder. Despite 50 years of clinical use, the mechanism of action is unknown. Multiple effects have been attributed to lithium including the uncompetitive inhibition of inositol monophospha
Autor:
Guy Daneels, Zsuzsanna Callaerts-Vegh, Stefan Kass, Theo Meert, Miroslav Cik, Arjan Buist, P. van der Spek, Diederik Moechars, Christian Rosenmund, Matthew C. Weston, Rudi D'Hooge, Sandra Leo, R. Mark Hampson, Ilse Goris
Publikováno v:
Journal of Neuroscience, 26(46), 12055-12066. Society for Neuroscience
Uptake ofl-glutamate into synaptic vesicles is mediated by vesicular glutamate transporters (VGLUTs). Three transporters (VGLUT1–VGLUT3) are expressed in the mammalian CNS, with partial overlapping expression patterns, and VGLUT2 is the most abunda