Chimeric Antigen Receptor (CAR) Regulatory T-Cells in Solid Organ Transplantation

Autor: Ilse Gille, Frans H. J. Claas, Geert W. Haasnoot, Mirjam H. M. Heemskerk, Sebastiaan Heidt

Publikováno v: Frontiers in Immunology, Vol 13 (2022)

Solid organ transplantation is the treatment of choice for various end-stage diseases, but requires the continuous need for immunosuppression to prevent allograft rejection. This comes with serious side effects including increased infection rates and

Externí odkaz: https://doaj.org/article/ca53edd64ac44976a296d7ac8b6a46ad

Identification of Functional HLA-A*01:01–Restricted Epstein-Barr Latent Membrane Protein 2–Specific T-Cell Receptors

Autor: Lieve E. van der Maarel, J.H. Frederik Falkenburg, Rob C. M. de Jong, Ilse Gille, Inge Jedema, Wesley Huisman, Derk Amsen, Lois Hageman, Laura T. Morton, Mirjam H.M. Heemskerk

Publikováno v: Journal of infectious diseases, 226(5), 833-842. Oxford University Press
The Journal of Infectious Diseases, 226(5), 833-842. OXFORD UNIV PRESS INC

Background Adoptive transfer of genetically engineered T cells expressing antigen-specific T-cell receptors (TCRs) is an appealing therapeutic approach for Epstein-Barr virus (EBV)–associated malignancies of latency type II/III that express EBV ant

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ffbb5ff5e84f14d8ed5aea1393f2b6c
https://doi.org/10.1093/infdis/jiaa512

The First Functional HLA-a*01:01-Restricted EBV-LMP2-Specific T-Cell Receptors for TCR Gene Therapy of Patients with EBV-Associated Type II/III Malignancies

Autor: Derk Amsen, Lieve E. van der Maarel, Lois Hageman, Inge Jedema, Fred Falkenburg, Rob C. M. de Jong, Ilse Gille, Wesley Huisman

Publikováno v: Blood. 134:4448-4448

Epstein Barr virus (EBV) is associated with the development of a broad range of malignancies, including Burkitt's lymphoma, Hodgkin and non-Hodgkin lymphomas, post-transplant lymphoproliferative disorder (PTLD), nasopharyngeal carcinoma and gastric c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d9b022215da64466f72bbb6523945463
https://doi.org/10.1182/blood-2019-123736