Zobrazeno 1 - 10
of 173
pro vyhledávání: '"Ilse D, Jacobsen"'
Autor:
Bettina Böttcher, Sandra D. Kienast, Johannes Leufken, Cristian Eggers, Puneet Sharma, Christine M. Leufken, Bianka Morgner, Hannes C. A. Drexler, Daniela Schulz, Stefanie Allert, Ilse D. Jacobsen, Slavena Vylkova, Sebastian A. Leidel, Sascha Brunke
Publikováno v:
Microbiology Spectrum, Vol 12, Iss 5 (2024)
ABSTRACTtRNA modifications play important roles in maintaining translation accuracy in all domains of life. Disruptions in the tRNA modification machinery, especially of the anticodon stem loop, can be lethal for many bacteria and lead to a broad ran
Externí odkaz:
https://doaj.org/article/a114f64854bb4cc889551a3b09495768
Autor:
Torben Mentrup, Anna Yamina Stumpff-Niggemann, Nadja Leinung, Christine Schlosser, Katja Schubert, Rebekka Wehner, Antje Tunger, Valentin Schatz, Patrick Neubert, Ann-Christine Gradtke, Janina Wolf, Stefan Rose-John, Paul Saftig, Alexander Dalpke, Jonathan Jantsch, Marc Schmitz, Regina Fluhrer, Ilse D. Jacobsen, Bernd Schröder
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-18 (2022)
Dectin-1 is a critical component of the innate sensing repertoire which is involved in pattern based recognition of fungal pathogens. Here the authors show that intramembrane proteolysis is involved in the regulation of the antifungal host response b
Externí odkaz:
https://doaj.org/article/f2acefb3574e4b9da6fd801ea20dcfc5
Autor:
Melissa Wich, Stephanie Greim, Marta Ferreira-Gomes, Thomas Krüger, Olaf Kniemeyer, Axel A. Brakhage, Ilse D. Jacobsen, Bernhard Hube, Berit Jungnickel
Publikováno v:
Virulence, Vol 12, Iss 1, Pp 3137-3148 (2021)
Candida albicans is a common commensal on human mucosal surfaces, but can become pathogenic, e.g. if the host is immunocompromised. While neutrophils, macrophages and T cells are regarded as major players in the defense against pathogenic C. albicans
Externí odkaz:
https://doaj.org/article/7e00c6e05b4c45499252c75561433240
Autor:
Yasmine Rebai, Lysett Wagner, Mayssa Gnaien, Merle L. Hammer, Mario Kapitan, Maria Joanna Niemiec, Wael Mami, Amor Mosbah, Erij Messadi, Helmi Mardassi, Slavena Vylkova, Ilse D. Jacobsen, Sadri Znaidi
Publikováno v:
Microorganisms, Vol 11, Iss 8, p 1929 (2023)
Candida albicans is a pathobiont of the gastrointestinal tract. It can contribute to the diversity of the gut microbiome without causing harmful effects. When the immune system is compromised, C. albicans can damage intestinal cells and cause invasiv
Externí odkaz:
https://doaj.org/article/95ef2d6f969a469b8f4c01e0f2cd356c
Autor:
Christine Dunker, Melanie Polke, Bianca Schulze-Richter, Katja Schubert, Sven Rudolphi, A. Elisabeth Gressler, Tony Pawlik, Juan P. Prada Salcedo, M. Joanna Niemiec, Silvia Slesiona-Künzel, Marc Swidergall, Ronny Martin, Thomas Dandekar, Ilse D. Jacobsen
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-20 (2021)
The ability of the fungal pathogen Candida albicans to undergo yeast-to-hypha transition is believed to be a key virulence factor. Here, Dunker et al. show that a filament-deficient strain is attenuated in a mouse model of intraperitoneal infection,
Externí odkaz:
https://doaj.org/article/56c898d46b974e6fb75c3234ffc538fb
Autor:
Berit Jungnickel, Ilse D. Jacobsen
Publikováno v:
Frontiers in Fungal Biology, Vol 3 (2022)
Animal models are essential to understand the pathophysiology of infections, to test novel antifungal compounds, and to determine the potential of adjunctive therapies, e.g. immune modulation. The murine model of systemic candidiasis induced by intra
Externí odkaz:
https://doaj.org/article/62b3e399c9754516b090988849502d8d
Autor:
Christin von Müller, Fionnuala Bulman, Lysett Wagner, Daniel Rosenberger, Alessandra Marolda, Oliver Kurzai, Petra Eißmann, Ilse D. Jacobsen, Birgit Perner, Peter Hemmerich, Slavena Vylkova
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-15 (2020)
Abstract Burn wounds are highly susceptible sites for colonization and infection by bacteria and fungi. Large wound surface, impaired local immunity, and broad-spectrum antibiotic therapy support growth of opportunistic fungi such as Candida albicans
Externí odkaz:
https://doaj.org/article/ba837634657b4b858d2cc5178fea1d41
Autor:
Silke Machata, Mario M. Müller, Roland Lehmann, Patricia Sieber, Gianni Panagiotou, Agostinho Carvalho, Cristina Cunha, Katrien Lagrou, Johan Maertens, Hortense Slevogt, Ilse D. Jacobsen
Publikováno v:
Virulence, Vol 11, Iss 1, Pp 1337-1351 (2020)
Invasive pulmonary aspergillosis (IPA) is a severe infection that is difficult to diagnose due to the ubiquitous presence of fungal spores, the underlying diseases of risk patients, and limitations of currently available markers. In this study, we pe
Externí odkaz:
https://doaj.org/article/5350df04459a440e9ade50dfa1dcae57
Autor:
Maria Joanna Niemiec, Mario Kapitan, Maximilian Himmel, Kristina Döll, Thomas Krüger, Tobias G. Köllner, Isabel Auge, Franziska Kage, Christopher J. Alteri, Harry L.T. Mobley, Tor Monsen, Susanne Linde, Sandor Nietzsche, Olaf Kniemeyer, Axel A. Brakhage, Ilse D. Jacobsen
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 12 (2022)
The human gut acts as the main reservoir of microbes and a relevant source of life-threatening infections, especially in immunocompromised patients. There, the opportunistic fungal pathogen Candida albicans adapts to the host environment and addition
Externí odkaz:
https://doaj.org/article/682d93fbc86f4b66a1076e5682332746
Autor:
Luke D. Halder, Emeraldo A. H. Jo, Mohammad Z. Hasan, Marta Ferreira-Gomes, Thomas Krüger, Martin Westermann, Diana I. Palme, Günter Rambach, Niklas Beyersdorf, Cornelia Speth, Ilse D. Jacobsen, Olaf Kniemeyer, Berit Jungnickel, Peter F. Zipfel, Christine Skerka
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-19 (2020)
Extracellular vesicles can carry immunoregulatory cytokines such as TGF-β. Here the authors use CD11b-deficient mice and macrophages to show that such vesicles carrying TGF-β are produced in response to Candida albicans infections and can limit the
Externí odkaz:
https://doaj.org/article/100b9457afd440a39a41c6760279cbb2