Supplementary Figure Legends from Primary Melanoma of the CNS in Children Is Driven by Congenital Expression of Oncogenic NRAS in Melanocytes

Autor: Richard Marais, Willeke A.M. Blokx, Pieter Wesseling, Benno Küsters, Caroline J. Springer, Ion Niculescu-Duvaz, Jolanda Schieving, Willy Renier, Ilse A. van Engen-van Grunsven, Jacobus H. Gilhuis, Berta Sanchez-Laorden, Patricia J.T.A. Groenen, Amaya Viros, Heidi V.N. Küsters-Vandevelde, Malin Pedersen

Supplementary Figure Legends PDF file - 92K, This file contains the Figure legends to Supplementary Figures 1-5

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b0aa9f1d1988d8356a6d76064cd6a7c7
https://doi.org/10.1158/2159-8290.22529580

Supplementary Figure 4 from Primary Melanoma of the CNS in Children Is Driven by Congenital Expression of Oncogenic NRAS in Melanocytes

Autor: Richard Marais, Willeke A.M. Blokx, Pieter Wesseling, Benno Küsters, Caroline J. Springer, Ion Niculescu-Duvaz, Jolanda Schieving, Willy Renier, Ilse A. van Engen-van Grunsven, Jacobus H. Gilhuis, Berta Sanchez-Laorden, Patricia J.T.A. Groenen, Amaya Viros, Heidi V.N. Küsters-Vandevelde, Malin Pedersen

Supplementary Figure 4 PDF file - 39K, Sequencing of RT-PCR amplified cDNA is presented to show that NRASG12D is expressed in the CNS tumors of our mice

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2741ff69ad00be20cc3114449000de66
https://doi.org/10.1158/2159-8290.22529586.v1

Supplementary Figure 1 from Primary Melanoma of the CNS in Children Is Driven by Congenital Expression of Oncogenic NRAS in Melanocytes

Autor: Richard Marais, Willeke A.M. Blokx, Pieter Wesseling, Benno Küsters, Caroline J. Springer, Ion Niculescu-Duvaz, Jolanda Schieving, Willy Renier, Ilse A. van Engen-van Grunsven, Jacobus H. Gilhuis, Berta Sanchez-Laorden, Patricia J.T.A. Groenen, Amaya Viros, Heidi V.N. Küsters-Vandevelde, Malin Pedersen

Supplementary Figure 1 PDF file - 795K, Data are presented to show that NRASG12D does not induce melanoma when expressed in the melanocytes of adult mice

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a8703c189596c2be9bdd440c1d9c66d
https://doi.org/10.1158/2159-8290.22529595.v1

Prediction of clinical benefit from androgen deprivation therapy in salivary duct carcinoma patients

Autor: Leonie I. Kroeze, Anja van de Stolpe, Gerald W. Verhaegh, Hans Van Zon, Yara Hendriksen, M.J.L. Ligtenberg, Wim van Boxtel, Dianne Arnoldina Margaretha Wilhelmina Van Strijp, Ilse A. van Engen ‐ van Grunsven, Jack A. Schalken, Carla M.L. van Herpen, Diederick Keizer

Publikováno v: International Journal of Cancer
International Journal of Cancer, 146, 11, pp. 3196-3206
International Journal of Cancer, 146, 3196-3206

Androgen deprivation therapy (ADT) is first‐line palliative treatment in androgen receptor‐positive (AR+) salivary duct carcinoma (SDC), and response rates are 17.6–50.0%. We investigated potential primary ADT resistance mechanisms for their pr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0555fc865a282e0a8cdba87f1eda44f0
https://hdl.handle.net/https://repository.ubn.ru.nl/handle/2066/220464

Primary Melanoma of the CNS in Children Is Driven by Congenital Expression of Oncogenic NRAS in Melanocytes

Autor: Benno Küsters, Richard Marais, Ion Niculescu-Duvaz, Amaya Viros, Malin Pedersen, Willeke A. M. Blokx, Jolanda H. Schieving, Berta Sanchez-Laorden, Heidi V.N. Küsters-Vandevelde, Caroline J. Springer, Ilse A. van Engen van Grunsven, Willy O. Renier, Jacobus H. Gilhuis, Pieter Wesseling, Patricia J. T. A. Groenen

Publikováno v: Pedersen, M, Kusters-Vandevelde, H V N, Viros, A, Groenen, P J T A, Sanchez-Laorden, B, Gilhuis, J H, van Engen-van Grunsven, I, Renier, W, Schieving, J, Niculescu-Duvaz, I, Springer, C J, Kusters, B, Wesseling, P, Blokx, W A M & Marais, R 2013, ' Primary Melanoma of the CNS in Children Is Driven by Congenital Expression of Oncogenic NRAS in Melanocytes ', Cancer discovery, vol. 3, no. 4, pp. 458-469 . https://doi.org/10.1158/2159-8290.CD-12-0464
Cancer Discovery, 3, 4, pp. 458-469
Pedersen, M, Küsters-Vandevelde, HVN, Viros, A, Groenen, PJTA, Sanchez-Laorden, B, Gilhuis, JH, van, E G IA, Renier, W, Schieving, J & Marais, R 2013, ' Primary melanoma of the CNS in children is driven by congenital expression of oncogenic NRAS in melanocytes. ', Cancer discovery, vol. 3, no. 4, pp. 458-469 . https://doi.org/10.1158/2159-8290.cd-12-0464
Cancer discovery, 3(4), 458-469. American Association for Cancer Research Inc.
Cancer Discovery, 3, 458-469

NRAS mutations are common in human melanoma. To produce a mouse model of NRAS-driven melanoma, we expressed oncogenic NRAS (NRASG12D) in mouse melanocytes. When NRASG12D was expressed in the melanocytes of developing embryos, it induced melanocyte pr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::69d3a6120380b5b7668625b8ad9a209d
https://research.vumc.nl/en/publications/8fb2252c-7085-457f-b0e1-c45060416f22