Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Ils Pijpers"'
Autor:
Rasmus Blaaholm Nielsen, René Holm, Ils Pijpers, Jan Snoeys, Ulla Gro Nielsen, Carsten Uhd Nielsen
Publikováno v:
Pharmaceutics, Vol 15, Iss 1, p 283 (2023)
P-glycoprotein (P-gp) limits the oral absorption of drug substances. Potent small molecule P-gp inhibitors (e.g., zosuquidar) and nonionic surfactants (e.g., polysorbate 20) inhibit P-gp by proposedly different mechanisms. Therefore, it was hypothesi
Externí odkaz:
https://doaj.org/article/a46f314b76934509a5e5f8a426054059
Autor:
Rasmus Blaaholm Nielsen, René Holm, Ils Pijpers, Jan Snoeys, Ulla Gro Nielsen, Carsten Uhd Nielsen
Publikováno v:
International Journal of Pharmaceutics: X, Vol 3, Iss , Pp 100089- (2021)
P-glycoprotein inhibitors, like zosuquidar, have widely been used to study the role of P-glycoprotein in oral absorption. Still, systematic studies on the inhibitor dose-response relationship on intestinal drug permeation are lacking. In the present
Externí odkaz:
https://doaj.org/article/a7a961e60a9f42388fa54a007c5b264b
Autor:
Sam Wouters, Ils Pijpers, Ninon Vanden Haute, Daniel Meston, Lieve Dillen, Filip Cuyckens, Sebastiaan Eeltink
Publikováno v:
Frontiers in Analytical Science. 2
This study reports on the potential of using ion-exchange suppressor technology in liquid chromatography—electrospray ionization mass spectrometry workflows. The aim was to use high salt concentrations to improve separation performance, while overc
Autor:
Thomas K van der Made, Jan Snoeys, Lieve Dillen, Ils Pijpers, Daniel Scotcher, Aleksandra Galetin, Sophie Jonkers, Mario Monshouwer, Amin Rostami-Hodjegan, Frank Jacobs, Annett Kunze, Kathleen Steemans, An Tuytelaars, Marie-Emilie Willemin
Publikováno v:
Willemin, M, Van Der Made, T K, Pijpers, I, Dillen, L, Kunze, A, Jonkers, S, Steemans, K, Tuytelaars, A, Jacobs, F, Monshouwer, M, Scotcher, D, Rostami-hodjegan, A, Galetin, A & Snoeys, J 2021, ' Clinical Investigation on Endogenous Biomarkers to Predict Strong OAT-Mediated Drug–Drug Interactions ', Clinical Pharmacokinetics . https://doi.org/10.1007/s40262-021-01004-2
BackgroundEndogenous biomarkers are promising tools to assess transporter-mediated drug–drug interactions early in humans.MethodsWe evaluated on a common and validated in vitro system the selectivity of 4-pyridoxic acid (PDA), homovanillic acid (HV
Autor:
Jan Snoeys, Rasmus Blaaholm Nielsen, Ils Pijpers, Carsten Uhd Nielsen, René Holm, Ulla Gro Nielsen
Publikováno v:
Nielsen, R B, Holm, R, Pijpers, I, Snoeys, J, Nielsen, U G & Nielsen, C U 2021, ' Oral etoposide and zosuquidar bioavailability in rats: Effect of co-administration and in vitro-in vivo correlation of P-glycoprotein inhibition ', International journal of pharmaceutics: X, vol. 3, 100089 . https://doi.org/10.1016/j.ijpx.2021.100089
International Journal of Pharmaceutics: X
International Journal of Pharmaceutics: X, Vol 3, Iss, Pp 100089-(2021)
International Journal of Pharmaceutics: X
International Journal of Pharmaceutics: X, Vol 3, Iss, Pp 100089-(2021)
P-glycoprotein inhibitors, like zosuquidar, have widely been used to study the role of P-glycoprotein in oral absorption. Still, systematic studies on the inhibitor dose-response relationship on intestinal drug permeation are lacking. In the present
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a7f42cd7e70e4f72b5251cdea48e097d
https://findresearcher.sdu.dk:8443/ws/files/192868127/1_s2.0_S2590156721000189_main_1_.pdf
https://findresearcher.sdu.dk:8443/ws/files/192868127/1_s2.0_S2590156721000189_main_1_.pdf
Autor:
Marie-Emilie Willemin, Thomas K. Van Der Made, Ils Pijpers, Lieve Dillen, Annett Kunze, Sophie Jonkers, Kathleen Steemans, An Tuytelaars, Frank Jacobs, Mario Monshouwer, Daniel Scotcher, Amin Rostami-Hodjegan, Aleksandra Galetin, Jan Snoeys
Publikováno v:
Clinical Pharmacokinetics. 61:463-463
Autor:
Lieve Dillen, René Holm, Dries Versweyveld, Jan Snoeys, Ils Pijpers, An Vermeulen, Carsten Uhd Nielsen, Ahmed A. Abdulhussein Al-Ali, Louis Sandra
Publikováno v:
Al-Ali, A A A, Sandra, L, Versweyveld, D, Pijpers, I, Dillen, L, Vermeulen, A, Snoeys, J, Holm, R & Nielsen, C U 2020, ' High-dose etoposide formulations do not saturate intestinal P-glycoprotein : Development, stability, and pharmacokinetics in Sprague-Dawley rats ', International Journal of Pharmaceutics, vol. 583, 119399 . https://doi.org/10.1016/j.ijpharm.2020.119399
It has been suggested that oral absorption of low-permeable P-glycoprotein (P-gp) substrates can be increased through saturation of P-gp. For BCS class IV drug substances, saturating P-gp is challenging due to low aqueous solubility. The present stud
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a66d796a4f9a56e88bc1be5b5f20e881
https://findresearcher.sdu.dk:8443/ws/files/170142161/High_dose_etoposide_formulations_do_not_saturate_1_intestinal.pdf
https://findresearcher.sdu.dk:8443/ws/files/170142161/High_dose_etoposide_formulations_do_not_saturate_1_intestinal.pdf
In vitro Phase I- and Phase II-Drug Metabolism in The Liver of Juvenile and Adult Göttingen Minipigs
Autor:
Els Van Peer, Steven Van Cruchten, Chris Van Ginneken, Ils Pijpers, Christophe Casteleyn, Jos Van Houdt, Jan Snoeys, Frank Jacobs
Publikováno v:
Pharmaceutical research
In view of pediatric drug development, juvenile animal studies are gaining importance. However, data on drug metabolizing capacities of juvenile animals are scarce, especially in non-rodent species. Therefore, we aimed to characterize the in vitro bi
Autor:
Steven Van Cruchten, Jos Van Houdt, Jan Snoeys, Chris Van Ginneken, Frank Jacobs, Els Van Peer, Ils Pijpers, Christophe Casteleyn
Publikováno v:
Reproductive Toxicology. 64:17