Zobrazeno 1 - 10
of 445
pro vyhledávání: '"Ilpo, Vattulainen"'
Autor:
Hanna Korolainen, Agnieszka Olżyńska, Wojciech Pajerski, Paulina Chytrosz-Wrobel, Ilpo Vattulainen, Waldemar Kulig, Lukasz Cwiklik
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-11 (2024)
Abstract Additives in vaping products, such as flavors, preservatives, or thickening agents, are commonly used to enhance user experience. Among these, Vitamin E acetate (VEA) was initially thought to be harmless but has been implicated as the primar
Externí odkaz:
https://doaj.org/article/f5d733655b174741b433fc67d0026809
Autor:
Johanna Lilja, Jasmin Kaivola, James R. W. Conway, Joni Vuorio, Hanna Parkkola, Pekka Roivas, Michal Dibus, Megan R. Chastney, Taru Varila, Guillaume Jacquemet, Emilia Peuhu, Emily Wang, Ulla Pentikäinen, Itziar Martinez D. Posada, Hellyeh Hamidi, Arafath K. Najumudeen, Owen J. Sansom, Igor L. Barsukov, Daniel Abankwa, Ilpo Vattulainen, Marko Salmi, Johanna Ivaska
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-20 (2024)
Abstract The KRAS oncogene drives many common and highly fatal malignancies. These include pancreatic, lung, and colorectal cancer, where various activating KRAS mutations have made the development of KRAS inhibitors difficult. Here we identify the s
Externí odkaz:
https://doaj.org/article/aab4a06c715b4e4481e20d3e6037ab7e
Autor:
Liang Wang, Ziyun Yang, Fudo Satoshi, Xavier Prasanna, Ziyi Yan, Helena Vihinen, Yaxing Chen, Yue Zhao, Xiumei He, Qian Bu, Hongchun Li, Ying Zhao, Linhong Jiang, Feng Qin, Yanping Dai, Ni Zhang, Meng Qin, Weihong Kuang, Yinglan Zhao, Eija Jokitalo, Ilpo Vattulainen, Tommi Kajander, Hongxia Zhao, Xiaobo Cen
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-30 (2024)
Abstract The Bin/Amphiphysin/Rvs (BAR) domain protein FAM92A1 is a multifunctional protein engaged in regulating mitochondrial ultrastructure and ciliogenesis, but its physiological role in the brain remains unclear. Here, we show that FAM92A1 is exp
Externí odkaz:
https://doaj.org/article/345ca2ed37524fef9b09f5e108e25a96
Autor:
Sarah Goellner, Giray Enkavi, Vibhu Prasad, Solène Denolly, Sungmin Eu, Giulia Mizzon, Leander Witte, Waldemar Kulig, Zina M. Uckeley, Teresa M. Lavacca, Uta Haselmann, Pierre-Yves Lozach, Britta Brügger, Ilpo Vattulainen, Ralf Bartenschlager
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-20 (2023)
Abstract For successful infection of host cells and virion production, enveloped viruses, including Zika virus (ZIKV), extensively rely on cellular lipids. However, how virus protein–lipid interactions contribute to the viral life cycle remains unc
Externí odkaz:
https://doaj.org/article/c80f076b90924328a6a5af50c805c795
Autor:
Melanie A. McDowell, Michael Heimes, Giray Enkavi, Ákos Farkas, Daniel Saar, Klemens Wild, Blanche Schwappach, Ilpo Vattulainen, Irmgard Sinning
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-16 (2023)
Abstract The eukaryotic guided entry of tail-anchored proteins (GET) pathway mediates the biogenesis of tail-anchored (TA) membrane proteins at the endoplasmic reticulum. In the cytosol, the Get3 chaperone captures the TA protein substrate and delive
Externí odkaz:
https://doaj.org/article/b6447c79d60b44f2a61ff200ac48153d
Autor:
Fabio Lolicato, Julia P Steringer, Roberto Saleppico, Daniel Beyer, Jaime Fernandez-Sobaberas, Sebastian Unger, Steffen Klein, Petra Riegerová, Sabine Wegehingel, Hans-Michael Müller, Xiao J Schmitt, Shreyas Kaptan, Christian Freund, Martin Hof, Radek Šachl, Petr Chlanda, Ilpo Vattulainen, Walter Nickel
Publikováno v:
eLife, Vol 12 (2024)
Fibroblast growth factor 2 (FGF2) exits cells by direct translocation across the plasma membrane, a type I pathway of unconventional protein secretion. This process is initiated by phosphatidylinositol-4,5-bisphosphate (PI(4,5)P2)-dependent formation
Externí odkaz:
https://doaj.org/article/2e4e6e3f4925498a9fc2d1adf0169274
Autor:
Calvin Dumesnil, Lauri Vanharanta, Xavier Prasanna, Mohyeddine Omrane, Maxime Carpentier, Apoorva Bhapkar, Giray Enkavi, Veijo T. Salo, Ilpo Vattulainen, Elina Ikonen, Abdou Rachid Thiam
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-13 (2023)
Dumesnil et al. report that cholesterol esters (CE), which only melt above body temperature, form supercooled liquid crystalline lipid droplets (LD). Triacylglycerols (TG) solubilize CE to help CE LD nucleation. Through clustering TGs in the ER membr
Externí odkaz:
https://doaj.org/article/1cacaf49d32d4b7a9a98a9bcd3cf7d33
Autor:
Shreyas Kaptan, Mykhailo Girych, Giray Enkavi, Waldemar Kulig, Vivek Sharma, Joni Vuorio, Tomasz Rog, Ilpo Vattulainen
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 20, Iss , Pp 3336-3346 (2022)
SARS-CoV-2 main protease (Mpro) involved in COVID-19 is required for maturation of the virus and infection of host cells. The key question is how to block the activity of Mpro. By combining atomistic simulations with machine learning, we found that t
Externí odkaz:
https://doaj.org/article/f909179a09dc44f4b4421958ff9c8ce8
Autor:
James H. A. Clubb, Tatiana V. Kudling, Mykhailo Girych, Lyna Haybout, Santeri Pakola, Firas Hamdan, Víctor Cervera-Carrascon, Annabrita Hemmes, Susanna Grönberg-Vähä-Koskela, João Manuel Santos, Dafne C. A. Quixabeira, Saru Basnet, Camilla Heiniö, Victor Arias, Elise Jirovec, Shreyas Kaptan, Riikka Havunen, Suvi Sorsa, Abdullah Erikat, Joel Schwartz, Marjukka Anttila, Katri Aro, Tapani Viitala, Ilpo Vattulainen, Vincenzo Cerullo, Anna Kanerva, Akseli Hemminki
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
IntroductionImmune checkpoint inhibitors (ICIs) have revolutionized the treatment of cancer, but preclinical testing of hypotheses such as combination therapies has been complicated, in part due to species incompatibility issues. For example, one of
Externí odkaz:
https://doaj.org/article/72872e048c8c48dd8faf69a636eddea5
Autor:
Shreyas Kaptan, Ilpo Vattulainen
Publikováno v:
Advances in Physics: X, Vol 7, Iss 1 (2022)
Machine learning has rapidly become a key method for the analysis and organization of large-scale data in all scientific disciplines. In life sciences, the use of machine learning techniques is a particularly appealing idea since the enormous capacit
Externí odkaz:
https://doaj.org/article/4d16ad1afae744f8a9b561174f2a9cde