Zobrazeno 1 - 10
of 44
pro vyhledávání: '"Ilona Sadok"'
4-Vinylpyridine copolymers for improved LC–MS tryptophan and kynurenine determination in human serum
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-12 (2024)
Abstract Tryptophan (an essential amino acid) and its clinically important metabolite—kynurenine contribute to several fundamental biological processes and methods that allow their determination in biological samples are in demand. The novelty of t
Externí odkaz:
https://doaj.org/article/8d8baf969aae44a7b6939d547493bfb9
Autor:
Ilona Sadok, Kinga Ożga, Daniel Klich, Wanda Olech, Dagny Krauze-Gryz, Agata Beliniak, Rafał Łopucki
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-14 (2023)
Abstract A new method for the determination of main glucocorticoids (cortisol, cortisone, and corticosterone) in hair by liquid chromatography-tandem mass spectrometry was developed. Glucocorticoids were extracted from hair shafts using methanol foll
Externí odkaz:
https://doaj.org/article/531059dbc978429f8baee126ed5ed7a2
Autor:
Agata Beliniak, Jakub Gryz, Daniel Klich, Rafał Łopucki, Ilona Sadok, Kinga Ożga, Karolina D Jasińska, Agnieszka Ścibior, Dorota Gołębiowska, Dagny Krauze-Gryz
Publikováno v:
PLoS ONE, Vol 19, Iss 5, p e0302933 (2024)
Animals in urban areas often encounter novel and potentially stressful conditions. It is important to understand how wildlife cope with anthropogenic disturbance. To investigate this specific adaptation we live-trapped squirrels in two study sites in
Externí odkaz:
https://doaj.org/article/2e1ca8b685694d44874e0545df5e7b60
Autor:
Ilona Sadok, Katarzyna Jędruchniewicz
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 22, p 16304 (2023)
Tryptophan metabolism plays an essential role in human health. In mammals, about 95% of dietary tryptophan is metabolized through the kynurenine pathway, which is associated with the development of several pathologies, including neurodegeneration. So
Externí odkaz:
https://doaj.org/article/e18dc509421a4ae6bc25d38713675a7e
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 36, Iss 1, Pp 581-592 (2021)
The kynurenine pathway is the major tryptophan degradation routes generating bioactive compounds important in physiology and diseases. Depending on cell type it is initiated enzymatically by tryptophan-2,3-dioxygenase (TDO) or indoleamine-2,3-dioxyge
Externí odkaz:
https://doaj.org/article/5beb9a035fb94edda59e9a8ed3659634
Publikováno v:
Pharmaceuticals, Vol 16, Iss 1, p 107 (2023)
Catabolism of tryptophan (Trp) is modulated by physical activity and provides a pool of active compounds: Trp is considered a calmative agent, kynurenine (Kyn) and 3-hydroxykynurenine (3-HKyn) show neurotoxic effects, kynurenic acid (Kyna) and xanthu
Externí odkaz:
https://doaj.org/article/1b72ae1d0bee421fba2aac04844a05f6
Publikováno v:
Metabolites, Vol 12, Iss 6, p 492 (2022)
We examined the relationships of tryptophan (Trp) and the metabolites of the kynurenine pathway (KP) to the occurrence of type 2 diabetes (T2D) and metabolic risk factors in obese middle-aged women. The study included 128 obese women divided into two
Externí odkaz:
https://doaj.org/article/43e39436a8504ffca91c23f7caa1684c
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 5, p 2429 (2022)
In this paper, we propose the first analytical procedure—using a screen-printed carbon electrode modified with carbon nanofibers (SPCE/CNFs)—for the detection and quantitative determination of an electroactive disubstituted fused triazinone, name
Externí odkaz:
https://doaj.org/article/20ed17865e6640a89237cc2a48b60c36
Autor:
Ilona Sadok, Magdalena Staniszewska
Publikováno v:
Sensors, Vol 21, Iss 21, p 7152 (2021)
In recent years, tryptophan metabolism via the kynurenine pathway has become one of the most active research areas thanks to its involvement in a variety of physiological processes, especially in conditions associated with immune dysfunction, central
Externí odkaz:
https://doaj.org/article/179ce9f816d841ba9d192dcee2f9e37f
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 13, p 6972 (2021)
Metabolites and enzymes involved in the kynurenine pathway (KP) are highly promising targets for cancer treatment, including gastrointestinal tract diseases. Thus, accurate quantification of these compounds in body fluids becomes increasingly importa
Externí odkaz:
https://doaj.org/article/3595fa2b2a0b420e9b0ffd079afca91b