Zobrazeno 1 - 10 of 10 pro vyhledávání: '"Ilona Nudelman"'
1
Affinity Isolation of Endogenous Saccharomyces Cerevisiae Nuclear Pore Complexes
Autor: Ilona, Nudelman, Javier, Fernandez-Martinez, Michael P, Rout
Publikováno v: Methods in Molecular Biology ISBN: 9781071623367
Methods Mol Biol
Studying protein complexes in vitro requires the production of a relatively pure sample that maintains the full complement, native organization, and function of that complex. This can be particularly challenging to achieve for large, multi-component,
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c1e181b188300369539c5572383a09f
https://doi.org/10.1007/978-1-0716-2337-4_1
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4
Integrative structure and functional anatomy of a nuclear pore complex
Autor: Riccardo Pellarin, Ilona Nudelman, Zhiheng Yu, Brian T. Chait, Joanna A. Hogan, Brian D. Slaughter, Javier Fernandez-Martinez, Seung Joong Kim, Jennifer L. Gerton, Charles H. Greenberg, Rosemary Williams, Paula Upla, Barak Raveh, Steven J. Ludtke, Ignacia Echeverria, David L. Stokes, Andrej Sali, Azraa S. Chaudhury, John D. Aitchison, Wenzhu Zhang, Manjunatha Shivaraju, Jay R. Unruh, Thurston Herricks, Christopher W. Akey, Erica Y. Jacobs, Ilan E. Chemmama, Yi Shi, Martin F. Jarrold, Roxana Mironska, Michael P. Rout, M. Jason de la Cruz, Junjie Wang
Publikováno v: Nature
Nature, Nature Publishing Group, 2018, 555 (7697), pp.475-482. ⟨10.1038/nature26003⟩
Nature, 2018, 555 (7697), pp.475-482. ⟨10.1038/nature26003⟩
Nuclear pore complexes play central roles as gatekeepers of RNA and protein transport between the cytoplasm and nucleoplasm. However, their large size and dynamic nature have impeded a full structural and functional elucidation. Here we determined th
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2cf1df4e9114f902daba1f64b28db9fe
https://doi.org/10.1038/nature26003
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5
A robust pipeline for rapid production of versatile nanobody repertoires
Autor: Sarah Keegan, Marlene Oeffinger, David Fenyö, Michel C. Nussenzweig, Peter C. Fridy, Brian T. Chait, Mary K Thompson, Johannes F. Scheid, Yinyin Li, Michael P. Rout, Ilona Nudelman
Publikováno v: Nature methods
Nanobodies are single domain antibodies derived from the variable regions of Camelidae atypical immunoglobulins. They show great promise as high affinity reagents for research, diagnostics and therapeutics due to their high specificity, small size (~
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b2e23408b90cd41a0fc4dd4ee0e8dfb
http://europepmc.org/articles/PMC4272012
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6
Structure and Function of the Nuclear Pore Complex Cytoplasmic mRNA Export Platform
Autor: Daniel Zenklusen, Javier Fernandez-Martinez, Michael P. Rout, Wenzhu Zhang, Paula Upla, Rosemary Williams, Brian T. Chait, David L. Stokes, Michael Gagnon, Seung Joong Kim, Andrej Sali, Yi Shi, Ilan E. Chemmama, Riccardo Pellarin, Ilona Nudelman, William J. Rice, Junjie Wang
Publikováno v: Cell, vol 167, iss 5
The last steps in mRNA export and remodeling are performed by the Nup82 complex, a large conserved assembly at the cytoplasmic face of the nuclear pore complex (NPC). By integrating diverse structural data, we have determined the molecular architectu
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e5fb3a51a91b0ae50263c3f52f2894b
https://escholarship.org/uc/item/16j2v6xk
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7
Molecular Architecture of the Nup82 Complex, the Cytoplasmic mRNA Export Platform in the Nuclear Pore Complex
Autor: Riccardo Pellarin, Ilona Nudelman, Michael P. Rout, Paula Upla, Andrej Sali, Brian T. Chait, Ilan E. Chemmama, Javier Fernandez-Martinez, David L. Stokes, Seung Joong Kim, Yi Shi
Publikováno v: Biophysical Journal. 110(3)
mRNA biogenesis is an essential and intricate process that occurs within the nucleus and ends with the mRNA export through the nuclear pore complex (NPC), a conserved process which defects lead to serious human diseases. The protein assemblies that p
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a2acde0266ffd7be146bca334b223c6d
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8
Observation of Intermolecular Interactions in Large Protein Complexes by 2D-Double Difference Nuclear Overhauser Enhancement Spectroscopy: Application to the 44 kDa Interferon–Receptor Complex
Autor: Jacob Anglister, Ilona Nudelman, Tali Scherf, Sabine R. Akabayov
Publikováno v: Journal of the American Chemical Society. 133:14755-14764
NMR detection of intermolecular interactions between protons in large protein complexes is very challenging because it is difficult to distinguish between weak NOEs from intermolecular interactions and the much larger number of strong intramolecular
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::241bdfa1d9a9013726a7cc2624d8ddb9
https://doi.org/10.1021/ja205480v
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10
Intermolecular interactions in a 44 kDa interferon-receptor complex detected by asymmetric reverse-protonation and two-dimensional NOESY
Autor: Yingqi Xu, Jacob Anglister, Daiwen Yang, Ilona Nudelman, Zohar Biron, Rina Levy, Sabine R. Akabayov, Einat Schnur
Publikováno v: Biochemistry. 49(25)
Type I interferons (IFNs) make up a family of homologous helical cytokines initiating strong antiviral and antiproliferative activity. All type I IFNs bind to a common cell surface receptor consisting of two subunits, IFNAR1 and IFNAR2, associating u
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc3e922cb4d36050baac97286badd31e
https://pubmed.ncbi.nlm.nih.gov/20496919
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